ID   A0A437PTF1_9BACT        Unreviewed;       799 AA.
AC   A0A437PTF1;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase family protein {ECO:0000313|EMBL:RVU25517.1};
GN   ORFNames=EOJ36_03620 {ECO:0000313|EMBL:RVU25517.1};
OS   Sandaracinomonas limnophila.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cytophagaceae;
OC   Sandaracinomonas.
OX   NCBI_TaxID=1862386 {ECO:0000313|EMBL:RVU25517.1, ECO:0000313|Proteomes:UP000282832};
RN   [1] {ECO:0000313|EMBL:RVU25517.1, ECO:0000313|Proteomes:UP000282832}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FSY-15 {ECO:0000313|EMBL:RVU25517.1,
RC   ECO:0000313|Proteomes:UP000282832};
RA   Chen W.-M.;
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC         NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC         Evidence={ECO:0000256|ARBA:ARBA00023693};
CC   -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC       {ECO:0000256|ARBA:ARBA00005005}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RVU25517.1}.
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DR   EMBL; SACY01000002; RVU25517.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A437PTF1; -.
DR   OrthoDB; 9771883at2; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000282832; Unassembled WGS sequence.
DR   GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   CDD; cd06558; crotonase-like; 1.
DR   Gene3D; 1.10.1040.50; -; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR   Pfam; PF00725; 3HCDH; 1.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF52096; ClpP/crotonase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000282832}.
FT   DOMAIN          7..202
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          206..305
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   799 AA;  88668 MW;  45C669087FF026EA CRC64;
     MNRSIKKVAI LGSGIMGSRI ACHFANIGVQ VLLLDIAPKE LTAEESAKGL SLEKVKNRIV
     NNAFQQTLKA KPASLYLDSF ANQITLGNFD DNLKDITTAD WIIEVVVENL EIKKTIYEKV
     EQFRKPGTLI SSNTSGIPIH LMTEGRTEDF KKHFCGTHFF NPPRYLKLLE IIPTDHTDPQ
     IIDFIQKYGT NELGKTTVIC KDSPAFIANR IGVYSMMQTM KVVEELGLSV EQVDKLTSKV
     VGRPKSGTFR LSDVVGLDTT VHVANNLYKA LSTDESREIF QLPSMLQKLM ENNWLGDKTG
     QGFYKKVKNE KGKSEILALD LKSFEYKPTQ KVSFETLERT KAIDSLPKRF GYLLEGKDLA
     GEFYRKTFLD GFRYASFRIP EIANELYKID QAICAGFGWE MGIFETWDAI GVAKGVELME
     ANGLSPAPWI KEMLASGNES FYKSQNGSLL FYDQKTKTYQ EIPGSKSTIS LNILKPEKVV
     FQNDDASIID IGDEVICLEF HSKMNTMGQG VLEGLQKAID LAEKNYRGLV VGNEGIEAFS
     AGANLGMLFM FAANQEFDEV NHMIALFQQS MMRVRYSSIP VVIAPHTLAL GGGTEICLHS
     DKLVAHAELY MGLVEVGVGL IPAGGGTKEM ALRMGDARQK GDIELNRLQN AFMNIATAKV
     STSAHEAKEM QYLRSFDRIV LNRSQLITEA KNEVLGLANA GYVQKQPRND VWVEGKQGLA
     LFKAGIHGMR KGNYISDHDA KIANKLAFAI CGGDLDAPQF VSEQYLLDLE REAFLSLSGE
     PKTLERISSL LGGGKPLRN
//