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Database: UniProt
Entry: A0A437S4A0_9FIRM
LinkDB: A0A437S4A0_9FIRM
Original site: A0A437S4A0_9FIRM 
ID   A0A437S4A0_9FIRM        Unreviewed;       433 AA.
AC   A0A437S4A0;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 14.
DE   RecName: Full=Glutamate--cysteine ligase {ECO:0000256|PIRNR:PIRNR017901};
DE            EC=6.3.2.2 {ECO:0000256|PIRNR:PIRNR017901};
GN   ORFNames=EF514_10445 {ECO:0000313|EMBL:RVU53841.1};
OS   Anaerosphaera multitolerans.
OC   Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC   Anaerosphaera.
OX   NCBI_TaxID=2487351 {ECO:0000313|EMBL:RVU53841.1, ECO:0000313|Proteomes:UP000288812};
RN   [1] {ECO:0000313|EMBL:RVU53841.1, ECO:0000313|Proteomes:UP000288812}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS7-6-2 {ECO:0000313|EMBL:RVU53841.1,
RC   ECO:0000313|Proteomes:UP000288812};
RA   Rettenmaier R., Liebl W., Zverlov V.;
RT   "Genome sequencing and assembly of Anaerosphaera sp. nov., GS7-6-2.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC).
CC       {ECO:0000256|PIRNR:PIRNR017901}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-cysteine + L-glutamate = ADP + gamma-L-glutamyl-L-
CC         cysteine + H(+) + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2;
CC         Evidence={ECO:0000256|PIRNR:PIRNR017901};
CC   -!- SIMILARITY: Belongs to the glutamate--cysteine ligase type 2 family.
CC       EgtA subfamily. {ECO:0000256|PIRNR:PIRNR017901}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RVU53841.1}.
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DR   EMBL; RLIH01000026; RVU53841.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A437S4A0; -.
DR   OrthoDB; 9780152at2; -.
DR   Proteomes; UP000288812; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004357; F:glutamate-cysteine ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042398; P:cellular modified amino acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0006750; P:glutathione biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.590.20; -; 1.
DR   InterPro; IPR035434; GCL_bact_plant.
DR   InterPro; IPR006336; GCS2.
DR   InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR   PANTHER; PTHR34378; GLUTAMATE--CYSTEINE LIGASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR34378:SF1; GLUTAMATE--CYSTEINE LIGASE, CHLOROPLASTIC; 1.
DR   Pfam; PF04107; GCS2; 1.
DR   PIRSF; PIRSF017901; GCL; 1.
DR   SUPFAM; SSF55931; Glutamine synthetase/guanido kinase; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR017901};
KW   Ligase {ECO:0000256|PIRNR:PIRNR017901, ECO:0000313|EMBL:RVU53841.1};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR017901}.
SQ   SEQUENCE   433 AA;  50494 MW;  0A6F97DD52D7A8FB CRC64;
     MNYKKQVNRI IDYIKSGEKN EENFTIGAEF ENFIVHKDSL KTVSYYGENG VGETILELSN
     QLKANPYYDN ENILGFTKND WSVSTEPGSQ FELSINSKKT IGELSEKYKD FIKILEPILN
     RKNQMLIALG YHPVTKIDEI TILPKKRYSF MFEHFKKRGN MAHNMMKGTA SVQVSIDFKN
     EADFIKKYFV GSAISPILYT MFDNSFIFES KPYDKQNLRQ KIWENTDSNR SGILALAFEK
     DLSYKKYAEY ILNTPPIFME KDGNVYSTGD KLFKELFDPD NDSDEVIFHM MSIVFPDLRL
     KKYLEFRMMD AVNYPLNISA VALIKALFYN EKALDDLYLK FKDVSYEDII NTKNSSYNYG
     YNATYMNEKI SDLAKYLINL AKKSLDYDEA LYLNPLLELV ENNIKPRDEF EKNYLEKGMR
     EAVINNKIEV SDV
//
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