ID A0A438LYF2_9ACTN Unreviewed; 935 AA.
AC A0A438LYF2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
GN ORFNames=EDD27_0803 {ECO:0000313|EMBL:RVX38491.1};
OS Nonomuraea polychroma.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=46176 {ECO:0000313|EMBL:RVX38491.1, ECO:0000313|Proteomes:UP000284824};
RN [1] {ECO:0000313|EMBL:RVX38491.1, ECO:0000313|Proteomes:UP000284824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43925 {ECO:0000313|EMBL:RVX38491.1,
RC ECO:0000313|Proteomes:UP000284824};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC {ECO:0000256|ARBA:ARBA00009809, ECO:0000256|RuleBase:RU003679}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RVX38491.1}.
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DR EMBL; SAUN01000001; RVX38491.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A438LYF2; -.
DR Proteomes; UP000284824; Unassembled WGS sequence.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.102.20.10; Beta-galactosidase, domain 2; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR018954; Betagal_dom2.
DR InterPro; IPR037110; Betagal_dom2_sf.
DR InterPro; IPR025972; BetaGal_dom3.
DR InterPro; IPR036833; BetaGal_dom3_sf.
DR InterPro; IPR025300; BetaGal_jelly_roll_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421:SF165; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR Pfam; PF13364; BetaGal_ABD2; 2.
DR Pfam; PF10435; BetaGal_dom2; 1.
DR Pfam; PF13363; BetaGal_dom3; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SMART; SM01029; BetaGal_dom2; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF117100; Beta-galactosidase LacA, domain 3; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000284824};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..935
FT /note="beta-galactosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5019288098"
FT DOMAIN 363..534
FT /note="Beta-galactosidase"
FT /evidence="ECO:0000259|SMART:SM01029"
SQ SEQUENCE 935 AA; 100291 MW; 076F7CD43F514412 CRC64;
MLLAMLLTCA ALVAPARAAA AREVTYDRYS LMVDGRRVVL QAAEFHYFRL PSPRLWRDVL
EKFKAAGFNA VSLYFSWAYH SPKSGVYDFT GVRDVDRLLR MASEAGLYVI ARPGPYINAE
SSGGGLPAWV KTVPGRARSS ESGYQAAYRE WLHHINPIIA RHQITGGGPV ILYNAENEYQ
VNTDAAYMQD IQDQARADGI DVPITTNDCC DGGSWSSTWA TGPGAVQIPG IDDYPQSFEC
ANPGLWGPWG EGLTERLRDD IPVFAAEYQA GAIDVGNAGY DKCRELTGPA FMKYFYKNNL
VTTGATMFSY YMGYGGTNWG WLAQPNDVYT SYDYGAPITE ARRLTPKYDE FKRQGYFLQA
VTPLAKTDPL AAPPVDNPAL TTVARANPDT GTQFVLVKHA DRAATSTDAA TLDWAGHRVP
VQVKGRDAHV LVAGYDLGAQ RLTLSTSELM THAAIGGRDV AVLYGTSGSP GATILRYGSE
PRVTVLDGRV TSTYSGGDLR LDYTHEGLAR VLVTGGGRRP LLLLIGTDAE AASFWRTDTA
SGPVLVRGTD LVRAASVNDG TVRLTADVAA AGEVEVFAPP AAHRLRIGAD DVRVTRTSSG
SLLGSTRPPG PAPLPALTGW RAHAESPEAQ PGFDDSRWTV ADRTTTTSPH PPKTLPVLYA
DDYGYHYGNV WYRGHFTATG AETTIDLNAV TGLRGNYLVW LNGRYLGSAA GGVQADSGDQ
WTPPNPDPGP GHFAIPSGLL KPGADNVIAV LVANMGHNDD WIADDLRFKQ PRGLVGASAG
GTPISWRIQG AAGVDPVRGG LNNGGLYGER TGWHLPTYPD KSWKPANPAA TPLPPGVTWY
RTSFRLDLPA NQDVPVGLRF GGEPSPAYLV QIFLNGWNVG QYGGDIGPQR EFSVPAGLLN
EHGTNTLALA VTAEQPVPAG PGPISLFAYG NVRVD
//
