ID   A0A438M7V6_9ACTN        Unreviewed;       533 AA.
AC   A0A438M7V6;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 12.
DE   SubName: Full=MecA-like transpeptidase family protein {ECO:0000313|EMBL:RVX41801.1};
GN   ORFNames=EDD27_4372 {ECO:0000313|EMBL:RVX41801.1};
OS   Nonomuraea polychroma.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=46176 {ECO:0000313|EMBL:RVX41801.1, ECO:0000313|Proteomes:UP000284824};
RN   [1] {ECO:0000313|EMBL:RVX41801.1, ECO:0000313|Proteomes:UP000284824}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 43925 {ECO:0000313|EMBL:RVX41801.1,
RC   ECO:0000313|Proteomes:UP000284824};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RVX41801.1}.
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DR   EMBL; SAUN01000001; RVX41801.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A438M7V6; -.
DR   OrthoDB; 5241017at2; -.
DR   Proteomes; UP000284824; Unassembled WGS sequence.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR007887; MecA_N.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF24; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE PBPA; 1.
DR   Pfam; PF05223; MecA_N; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF54427; NTF2-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000284824}.
FT   DOMAIN          34..140
FT                   /note="NTF2-like N-terminal transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF05223"
FT   DOMAIN          263..530
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   533 AA;  55326 MW;  CA700ECDF7B27B4F CRC64;
     MARGRTIAIV SAATVLGVGA AAGGAYYVLH TRGTPAETAQ RFAAAWQAGD WSAMGKELAT
     AQQLGGYDQQ RRALAVERTS IRLGKVTEGD GMARVPYTAT LTLKNIGEWT YDGRIDLVVA
     DRAWKVDWAP TTLHPSMTAG ATFGIKTRWP QRAEITDADG GRIDDGTVGG SVQQLVGYLD
     KATKKDVAKL GSAYKVGQAV GRDGLQETFQ KQLAGTPATD IQLGGKTLTT IKGTEGEPVQ
     TTLDPHVQAA AVNAVKDMDK PTSMVAIKPS TGEILSVVNN QGGFNRALDG RYPPGSTFKA
     VTAIGLLAAG MSPQDTVTCP MYATVGGLKI RNSDKEEFGS LSFLDSFAHS CNTTFAPLAQ
     SKLGADKLLD VAQDVGFNQP LNIGVPATKA SFPKAETDAE LAAEAFGQAR ITASPLSMAS
     VAAAIADGTW RPPTLVPSLK QKAAERPLPD GVKEHLHAMM AAVVTKGTAK AAGLPAGTHG
     KTGTAEYGTG EKLESHAWFM GFKGDVAFAV VVEGGGGGGK VAAPVAADFL KGL
//