ID A0A438MN74_9ACTN Unreviewed; 1382 AA.
AC A0A438MN74;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Glycosyl hydrolase family 38 {ECO:0000313|EMBL:RVX47247.1};
GN ORFNames=EDD27_10170 {ECO:0000313|EMBL:RVX47247.1};
OS Nonomuraea polychroma.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=46176 {ECO:0000313|EMBL:RVX47247.1, ECO:0000313|Proteomes:UP000284824};
RN [1] {ECO:0000313|EMBL:RVX47247.1, ECO:0000313|Proteomes:UP000284824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43925 {ECO:0000313|EMBL:RVX47247.1,
RC ECO:0000313|Proteomes:UP000284824};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC {ECO:0000256|ARBA:ARBA00009792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RVX47247.1}.
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DR EMBL; SAUN01000001; RVX47247.1; -; Genomic_DNA.
DR OrthoDB; 1049785at2; -.
DR Proteomes; UP000284824; Unassembled WGS sequence.
DR GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR CDD; cd10786; GH38N_AMII_like; 1.
DR Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR InterPro; IPR018905; A-galactase_NEW3.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR InterPro; IPR011682; Glyco_hydro_38_C.
DR InterPro; IPR015341; Glyco_hydro_38_cen.
DR InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR InterPro; IPR000602; Glyco_hydro_38_N.
DR InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR Pfam; PF09261; Alpha-mann_mid; 1.
DR Pfam; PF07748; Glyco_hydro_38C; 1.
DR Pfam; PF01074; Glyco_hydro_38N; 1.
DR Pfam; PF10633; NPCBM_assoc; 1.
DR SMART; SM00872; Alpha-mann_mid; 1.
DR SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 2.
DR SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000313|EMBL:RVX47247.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000284824}.
FT DOMAIN 408..479
FT /note="Glycoside hydrolase family 38 central"
FT /evidence="ECO:0000259|SMART:SM00872"
FT REGION 1251..1277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1382 AA; 148657 MW; 98C7360FC34B21A9 CRC64;
MPVRLLSAES TDLFVGSPGE PHQVLRVTVA QGEQDTPLEL RGEGVRLAEP VTVPATASGA
LEIPLVLTAP PGAALPCVVM LGEESLEVTV TAEEPGWTMH MVSHFHYDPV WWNTQAAYTS
PWELLSGDAT TRPLWERNAF ALVEAHIELA LRDPDYRFVL AEVDYLKPFF DTHPERRADL
RALMAEGRVE LIGGTYNEPN TNLTGAESTI RNLVYGIGYQ RDILGGDPRT AWQLDVFGHD
PQFPGYLAAA GLTGSAWARG PFHQWGPIHK NFQQAKNDAT MMQFPSEFEW ISPSGQGVLT
HYMPAHYSAG WWMDSTPTLE DACQAVHDLY RALKPVAATK NILLPVGTDY TPPNKWVTDI
HRTWADRYVW PRFVCATPRD FLNAVRADMS RFSPQTRDMN PIYTGKDVSY IDTKQAQRAA
EVAALDAERL SAFAAVLGLG RYPHTALDKV WRQLAYGAHH DAITGSESDQ VYIDLLTGWR
EAYDLATTAR DTALDALTGR IAVETASVVV TNTLPFARDG LARVRLPAGH TLAGVAAVVE
DGTLTFLARD IPSMGWRTHR VVPGSPATWQ PAPASASGVI TMENDRWRIT ADPSRGGGLT
SIVDLASGQE LLSGLGNELR LYHEYPQHPD MGEGPWHLIP TGEATGSGES RALTARAETS
PIGQRLIVTG QVGEISYEQI VTLVSGSDRI DFTTRVLDHT GADRLLRVRF PARVEGALPV
SDVSGAVVGR GFALPDVDTA EHPWTLDNPA NTWFGLSTTA KVDLGEAGAR ALGVAEVVVP
TPADAPEARD LVVALARAGV TATTSSASGT RYGWLDVDSN LPDVRIVVGG PDINPVAADV
LAEADPAYLE ALKSGAPRVW VPAERPLPEV WQPSADLRDL RALPALIVAG PVADLVADLA
DATIEAACPL GAERLEDRTV ALLAYGLPGF AVDPDGALHL SLMRSCTGWP SGIWLDPPHR
TTPDGSGFQL QHWTHEFSYA LVAGQGDWRA LRLPAAAQDH ITPFLTRTLN AQDGDLAPTH
SLLTLSPPRD VLLSTIKATG NPHAHGRTTE RDHGLTIRLI ESTGLGSRVT IGSPILPLDD
LTHSDLLERP GTPVSDLNLT GFEVATYLAP APPSPEEPEL GPTTEQAQPV YSRYWLHNKG
PAPLGFLPIS IAISPGLVTS AEGPFEVEVV VSSHLTDEPH EGMVDLRVPE GWTATPARRP
VRLPPGGHVR FPVTVTPPPQ GTGLYFVSAR TFAGGQLIED VTTVAVGDDI PELPVSGPPP
ASGTAVKGTS SPEARPTGLS IIPATDALSL RPGDRTALVL RLTNTTADEI RGESQLASPW
GTWALLPEVI QGFTVAAGET AEVSFPVDVP EDAPAGHAWA LAKVMWYGRC QYTPAIRLEV
TR
//
