ID   A0A439CT72_9PEZI        Unreviewed;       527 AA.
AC   A0A439CT72;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   RecName: Full=Squalene--hopene cyclase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=EKO27_g9754 {ECO:0000313|EMBL:RWA05355.1};
OS   Xylaria grammica.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Xylariaceae; Xylaria.
OX   NCBI_TaxID=363999 {ECO:0000313|EMBL:RWA05355.1, ECO:0000313|Proteomes:UP000286045};
RN   [1] {ECO:0000313|EMBL:RWA05355.1, ECO:0000313|Proteomes:UP000286045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IHI A82 {ECO:0000313|EMBL:RWA05355.1,
RC   ECO:0000313|Proteomes:UP000286045};
RA   Buettner E., Kellner H.;
RT   "Draft genome sequence of Xylaria grammica IHI A82.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RWA05355.1}.
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DR   EMBL; RYZI01000450; RWA05355.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A439CT72; -.
DR   STRING; 363999.A0A439CT72; -.
DR   Proteomes; UP000286045; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR11764:SF82; TERPENE CYCLASE_MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SUPFAM; SSF81853; Family 10 polysaccharide lyase; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE   4: Predicted;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286045};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          18..318
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          329..527
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   527 AA;  58478 MW;  F292B4461D2A6916 CRC64;
     MSQPQGTTLK DGARLSLQQA VKFSWACQQS DGHWVAPVHS DATFTAQYVM FKYAIPGLSL
     EADGGILRKW LFADQTEDGS WAAAPGLPGS LSTTVEAYLA LKLLDVPASH PAMKRARDFV
     LSQGGVAKAR FFTRLYLASF GLYPWSAIPQ IPAELILVPT WAPINVYVLS YWARCALIPM
     LIIRHHEPIY SLPNGHSPDN DFLDELWLDP SDKNVPFTPP LWDLFCGKDR DAIKWLFVAG
     DKLLSRVGGL KKGPQRRLAR QRCIDWLLER QEEQGDWGGG AFTFIHPSIW ALLLEGFPLQ
     HKAVRLGLQA LERLAITDAK GKWLQVTPSP VWDTTLMTEA LCDAGLSSDA RLNQAAAWLR
     DRQITADHGD WRVNSSTSQP GSWGFQYYNT SYPDVDDTAV VVMTLVKQDP LAIASDCVLN
     AVQWILGMQN KDGGWGAFDA NNDARWLQKI PLGLDSDSLV DPSTPDVTGR MLECFGFLLA
     NRKGACLPGP IQHRLRVAAK RALRCLLRDQ ESEGAASGSW WGRWGNN
//