ID A0A439D5D8_9PEZI Unreviewed; 945 AA.
AC A0A439D5D8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=HMA domain-containing protein {ECO:0000259|PROSITE:PS50846};
GN ORFNames=EKO27_g5444 {ECO:0000313|EMBL:RWA09637.1};
OS Xylaria grammica.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Xylariaceae; Xylaria.
OX NCBI_TaxID=363999 {ECO:0000313|EMBL:RWA09637.1, ECO:0000313|Proteomes:UP000286045};
RN [1] {ECO:0000313|EMBL:RWA09637.1, ECO:0000313|Proteomes:UP000286045}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IHI A82 {ECO:0000313|EMBL:RWA09637.1,
RC ECO:0000313|Proteomes:UP000286045};
RA Buettner E., Kellner H.;
RT "Draft genome sequence of Xylaria grammica IHI A82.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|RuleBase:RU362081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWA09637.1}.
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DR EMBL; RYZI01000145; RWA09637.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A439D5D8; -.
DR STRING; 363999.A0A439D5D8; -.
DR Proteomes; UP000286045; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 2.
DR Gene3D; 3.30.70.100; -; 2.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF32; COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG); 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 2.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 2.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 1.
DR PROSITE; PS50846; HMA_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000286045};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 371..393
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 413..432
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 468..489
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 501..519
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 658..680
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 700..722
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 10..75
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 192..258
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT REGION 147..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 945 AA; 101360 MW; 68A475D6C95752A9 CRC64;
MAPSMPSHPF VTTFLVANIH CPTCVSSIKD ALQGLDGVRW VSPNIITSCV SVDHNPAIPI
MNIVTKLEAA GFEVSSLSSG NGVAYPDNTP HGDAQSLGNL GAVEDCLSRF RRLTHTRGAM
ADEERAKAHL NNCEQCRAET ANGNAAIPGT TLDTGYKQPS PVTSKRGSAR NVTTPAHSSS
ALDDGVVATT SWKASLAISG MTCAACANAI TTELDKKDWV TKATINLVSN SAAVEYIGDK
EDVSQVIESI EDLGYDAHLD QIIAVSDERE KEILHQRTIQ IRIDGFYCPH CGDHVASSVA
SFQQYIRIDS RPTTQRPVLE ITYVPQAPAF TIRHILAAIE ASDPAFKASI YHPPTLEERA
KKIQAQHQKQ IFLRALLTLI IAIPTFAIGI VYMSLLPESN PGKKYLMKPW VSGINRAEIA
LFILATPVYF GAADVFHRRT IREIWSLWRP GSQAPILRRL YRFGSMNMLI SLGTTIAYVS
SIAQMIAAGA KNLHMIDDKD FYFDSVVFLT LFLLVGRFLE AYSKSKTGNA VEALGKLRPT
TAILVEETKS QSTSDKVVGT DMLEFGDTVR VPHGASPPCD GEVLQGNTIF DEASLTGESR
PIKKYVGDEV FSGTVNQGTP ILIRITGTAG QSMLDKIVKV VREGQTKRAP MEKVADALVA
YFVPVITSIA VITWIVWLII GFTNDDLRVK DPVPFSLQFA IAVFVVACPC GLALAAPTAI
FVGGGLAAKY GILVKGGGEA FETASRIDCV VFDKTGTLTV GGEPSVTDSE TYLDGSDEDK
VSTRLFAALR AVEENSSHPI AKAIVAYCKT KTSDTVAVGD VEEIPGKGLK AFCSGDKQDE
GFDILVGNEA LLRDFSVGIP SAAATALETW KTEAKSVALV ATKSSGPETK YVLSAALSIS
DPIRPETPAV ISSLRNNGCD VWMLSGDNAV TPAGSRFASG SPKTT
//
