ID A0A439D7N6_9PEZI Unreviewed; 1066 AA.
AC A0A439D7N6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=TOG domain-containing protein {ECO:0000259|SMART:SM01349};
GN ORFNames=EKO27_g4691 {ECO:0000313|EMBL:RWA10413.1};
OS Xylaria grammica.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Xylariaceae; Xylaria.
OX NCBI_TaxID=363999 {ECO:0000313|EMBL:RWA10413.1, ECO:0000313|Proteomes:UP000286045};
RN [1] {ECO:0000313|EMBL:RWA10413.1, ECO:0000313|Proteomes:UP000286045}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IHI A82 {ECO:0000313|EMBL:RWA10413.1,
RC ECO:0000313|Proteomes:UP000286045};
RA Buettner E., Kellner H.;
RT "Draft genome sequence of Xylaria grammica IHI A82.";
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Microtubule binding protein that promotes the stabilization
CC of dynamic microtubules. Required for mitotic spindle formation.
CC {ECO:0000256|ARBA:ARBA00024889}.
CC -!- SUBUNIT: Interacts with microtubules. {ECO:0000256|ARBA:ARBA00011375}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}.
CC -!- SIMILARITY: Belongs to the CLASP family.
CC {ECO:0000256|ARBA:ARBA00009549}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWA10413.1}.
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DR EMBL; RYZI01000115; RWA10413.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A439D7N6; -.
DR STRING; 363999.A0A439D7N6; -.
DR Proteomes; UP000286045; Unassembled WGS sequence.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000278; P:mitotic cell cycle; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF9; CLIP-ASSOCIATING PROTEIN; 1.
DR Pfam; PF12348; CLASP_N; 2.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000286045}.
FT DOMAIN 1..224
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 250..492
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 195..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..686
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..761
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..565
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1066 AA; 116517 MW; 82FD2D748DF13A29 CRC64;
MAERLTDDQV QGLLAILKKE TTIDAKVQYV TTVKSGIKQH NVPDTCVAPL FEGLRQASTS
QHAALVNAGF TALNHLLTRL SRQEPKYLHR EAKLTLPLIV EKMGDQKDKF RALAIQAMAT
MYAHVPADAE RFVRNAAMIS KNPRAKESGL QWLLQKMQMA WEAPNAAKSD LKKQLKNFKV
RPAIESAIIK ELNPAGVRSD PESRPASAMQ VRPNLTTSAS SNVSDRPTTP MLPEAKTESV
EPIYVNTQRE LDEIIKGMHE WFEGKETEQN WMKREESMTK LRRLIAGNAS TDFPDLVISG
CRGLLDGIIK AVNSLRTSLC KEGCALVQDL AVTFGPGIDP MVELLMQTFI KLCAATKKIS
SQLANSAVDT IVGRTTYTVR IMQHIWAACQ DKNVQPRLYS TGWLKTLLKK EAHHKNHLEH
GGGVDLIEKC IKKCLNDPNP GVREKMRSTY WAFAAIWQSR AETVMDGLDS TAQKLLQKDP
SNPNSSKRTE PVARPGLGLS KSTMGTSKPS LREAMMAQKK ALASKNLPAR PGSAMATISP
VRTAPTTSAA SSQPATRTRP ESSMKSHGGM SVAPMRPTRR RPEIAARPAT AGPYSVRTHD
GPSAERSSPE SIKPKAITPK AISGSPRRTA PRTRAGHATT ASESNISAST PSKAPVNQAV
ASPRASPPKA KTTLGHIPSS SPSKDENLTF LAAPAIENLK ESLQPSPRVI ASPQNVSHVA
HIPSLEAASP PQAEPAPLPE PQKELTKMLP PSTPEATPSK PLQVYEDPFV EDQATPQPQS
NKPIERPALE NIPINEDVAK LAQIPTETSD TVPPCSPDKT RQNSRLLESG ITRVKGQTLD
VHGFRKLQSL IRENKLPFGD DKFNALLVGL FDYLESPLDG LAAQKVQDIK AQVLATVKLL
LKMHSESFQP HVSRGLEALL RTRSSYDART HIVAGLELLA DELVHIGDAD EITMTMTRSL
GQVDLDAAGY RGLSMGLHVL KELIDSRPSF IPTEREISGL TGLASRCLES KESGVRMDAV
QLCVALHARL GDAQFWESMK TVRDDPKSLI TYYVVKRQRE AKSTPC
//
