ID   A0A439DGQ7_9PEZI        Unreviewed;       743 AA.
AC   A0A439DGQ7;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE            EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN   ORFNames=EKO27_g1515 {ECO:0000313|EMBL:RWA13590.1};
OS   Xylaria grammica.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Xylariaceae; Xylaria.
OX   NCBI_TaxID=363999 {ECO:0000313|EMBL:RWA13590.1, ECO:0000313|Proteomes:UP000286045};
RN   [1] {ECO:0000313|EMBL:RWA13590.1, ECO:0000313|Proteomes:UP000286045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IHI A82 {ECO:0000313|EMBL:RWA13590.1,
RC   ECO:0000313|Proteomes:UP000286045};
RA   Buettner E., Kellner H.;
RT   "Draft genome sequence of Xylaria grammica IHI A82.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RWA13590.1}.
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DR   EMBL; RYZI01000023; RWA13590.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A439DGQ7; -.
DR   STRING; 363999.A0A439DGQ7; -.
DR   Proteomes; UP000286045; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   Gene3D; 6.20.120.20; -; 1.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362003};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022955};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022955};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286045};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Steroid biosynthesis {ECO:0000256|ARBA:ARBA00022955}.
FT   DOMAIN          138..338
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          403..733
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   743 AA;  85483 MW;  2E7BE8B9FC9AB461 CRC64;
     MVQTRSNGFD QPSRKRASNG HVDANMKQSR IADKTDRSRW RLLDESGRLT WHYLETEEAA
     NEWPQSTADR WYLGLDINLP DLAKPKKPLD AVSNGLAFFE KLQLPAGEWG CEYGGPMFLL
     PGIVITWYAT KKPIPWYVAT EIKNYLFARA HPKDGGWGLH IEGDSSVFGT SLNYTVLRLV
     GVDPEHPVMV KARKTLHKLG GATHAPHWAK FWLSVLGVCK WDIVNPIPSE IWLLPDWVPF
     APWRWWIHIR QVFLPMGYIY DKQWACEETD VIRGLREELF TENWEKIDWA GNRNTICPAD
     NYHPKTWVLN TANWALVNVW PWLRPNFLKN RANEWVSKLI DMEDANTDYA DLAPVNAALN
     TVVCYIRDGQ NAVSYRKHIE RLEDAMWVNA EGMFCNGTNG VQCWDTSFLI QAAVDAGLEQ
     DARWRPMLER ALTFLDKQQI RENCKDQAIC YRQQRKGAWA FSTKDQGYAV CDCVSEALKS
     VILLQKTPGY PQLLDDERIF DAVDTILTYQ NQTGACSSYE PTRGSEKLEW LNAAEVFGKI
     MVEYDYVECT TAVVTALSLF GKYWPDHRSK EIEGFVQRSV AWIKTAQQPD GSWYGNWAIC
     FTYATMFALE SLKSIGEKYS NSYYSKRGCD FLISRQREDG GWSESYRSCE KMVYTEHATG
     SQVVMTAWAL IALMHADYPD IEPIKRGIRL IMERQQPNGE WKQEAIEGVF NKSCMISYPN
     YKFTFTMKAL GMFATKYPDE TII
//