ID   A0A439DKS6_9PEZI        Unreviewed;      1008 AA.
AC   A0A439DKS6;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   13-SEP-2023, entry version 13.
DE   RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=EKO27_g58 {ECO:0000313|EMBL:RWA15017.1};
OS   Xylaria grammica.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Xylariomycetidae; Xylariales; Xylariaceae; Xylaria.
OX   NCBI_TaxID=363999 {ECO:0000313|EMBL:RWA15017.1, ECO:0000313|Proteomes:UP000286045};
RN   [1] {ECO:0000313|EMBL:RWA15017.1, ECO:0000313|Proteomes:UP000286045}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IHI A82 {ECO:0000313|EMBL:RWA15017.1,
RC   ECO:0000313|Proteomes:UP000286045};
RA   Buettner E., Kellner H.;
RT   "Draft genome sequence of Xylaria grammica IHI A82.";
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RWA15017.1}.
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DR   EMBL; RYZI01000001; RWA15017.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A439DKS6; -.
DR   STRING; 363999.A0A439DKS6; -.
DR   Proteomes; UP000286045; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd05992; PB1; 1.
DR   CDD; cd13246; PH_Scd1; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR010481; Cdc24/Scd1_N.
DR   InterPro; IPR033511; Cdc24/Scd1_PH_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR000270; PB1_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR47339; CELL DIVISION CONTROL PROTEIN 24; 1.
DR   PANTHER; PTHR47339:SF1; CELL DIVISION CONTROL PROTEIN 24; 1.
DR   Pfam; PF06395; CDC24; 1.
DR   Pfam; PF00564; PB1; 1.
DR   Pfam; PF15411; PH_10; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00666; PB1; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS51745; PB1; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000286045}.
FT   DOMAIN          236..410
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          910..1006
FT                   /note="PB1"
FT                   /evidence="ECO:0000259|PROSITE:PS51745"
FT   REGION          587..835
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          390..417
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        603..649
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        686..723
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        756..790
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        811..835
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1008 AA;  110744 MW;  D2455AE9C7812A14 CRC64;
     MAHAPALLRT NTAPVFPANN NYGGASSTMN SLRASHLSGS TAVNSASTTS LASMASSSTI
     VPSSNGVVAT ANIINQRADA SRSLYQICAA LKQRLAKVPD FEGYLQAIEQ DIMANESNPV
     DAVWGLLKSG DPLLAIYNSI KPDVPLNPSD ITADPARRPK AATFKFIDAC LRQLLIPAAE
     CFIVSDLMNE DTTGFVKVIQ VINHVLDVAE QRGHLLQIQP YPEDGSFEGP TGQMTYRDHI
     IRELVDTERK YVQDLENLHD LKKSLLDKAV IPGDVAYQIF LNIHGILDFQ RKFLIRVETT
     NSMPQAAQQW GAIFINNEEG FEIYQPFIAN QRKAAQIANQ AFDKIQLAEH PVACDFNTLD
     GFLLKPMQRL VKYPLLLKDL LKRGDVPESK EELTRGIEAA ERVLKQANEA VNRALLKDAL
     DELKFRVDDW KSHKIDHFGE LLLHGSYQVI TGRSEQEKDY EIYLFEHILL CCKEAQASKS
     KEKKDKNKSA SKARNKSSKL QLKGRIFMSN VTEVISFAKP GSYTVQIWWK GDPGVESFII
     KYNNEEIMKK WATGLDVQRK LNMPSTASPE QPTPDFTWMR GVTTENPYVQ QDDDDDDDDE
     QPGPSQMSSP NLGYSSNSSG GMMARNTSSN NLRARSVTTD STQSLASLAR APPPQFPLPV
     PPRQLSVQTG GAQSPVPRGG ESYFSPTADS PASSRTSTAS TLLTQNGQYP FPRTSTPQGG
     WEERDTNRYT APAMPRAPSR DGPTPINGRN PRGPSMPVMA SQQTLAQQQR NRSYSTPDIN
     GQNARRANTT TPVPAVPGIP PHLHPAHDAS IPRSQTGSPR QDPPMRANTQ SPGAQRERLN
     QQNGQYGGTM AQFPTQPIYP RQATPSTGQI SGSSAPQPLN LDGRLVVSSA LGSVAAGNPP
     STEDLPIPTQ LRVKVNCDTG TYVTLVVPFS ITYQSLSDRI DGKLARFTNS SISKGNLRLK
     YRDEDGDLVT IESDDDIQIA FLEWREGASN MYTNGVGEIE LFCVGDMN
//