ID A0A443HSD9_BYSSP Unreviewed; 696 AA.
AC A0A443HSD9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=RNA lariat debranching enzyme {ECO:0000313|EMBL:RWQ94689.1};
GN ORFNames=C8Q69DRAFT_301118 {ECO:0000313|EMBL:RWQ94689.1};
OS Byssochlamys spectabilis (Paecilomyces variotii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX NCBI_TaxID=264951 {ECO:0000313|EMBL:RWQ94689.1, ECO:0000313|Proteomes:UP000283841};
RN [1] {ECO:0000313|EMBL:RWQ94689.1, ECO:0000313|Proteomes:UP000283841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101075 {ECO:0000313|EMBL:RWQ94689.1,
RC ECO:0000313|Proteomes:UP000283841};
RX PubMed=30619145; DOI=10.3389/fmicb.2018.03058;
RA Urquhart A.S., Mondo S.J., Makela M.R., Hane J.K., Wiebenga A., He G.,
RA Mihaltcheva S., Pangilinan J., Lipzen A., Barry K., de Vries R.P.,
RA Grigoriev I.V., Idnurm A.;
RT "Genomic and genetic insights into a cosmopolitan fungus, Paecilomyces
RT variotii (Eurotiales).";
RL Front. Microbiol. 9:3058-3058(2018).
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the lariat debranching enzyme family.
CC {ECO:0000256|ARBA:ARBA00006045}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWQ94689.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; RCNU01000007; RWQ94689.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A443HSD9; -.
DR STRING; 264951.A0A443HSD9; -.
DR OrthoDB; 1220605at2759; -.
DR Proteomes; UP000283841; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008419; F:RNA lariat debranching enzyme activity; IEA:UniProt.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR CDD; cd00844; MPP_Dbr1_N; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR007708; DBR1_C.
DR InterPro; IPR041816; Dbr1_N.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR PANTHER; PTHR12849:SF0; LARIAT DEBRANCHING ENZYME; 1.
DR PANTHER; PTHR12849; RNA LARIAT DEBRANCHING ENZYME; 1.
DR Pfam; PF05011; DBR1; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SMART; SM01124; DBR1; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Reference proteome {ECO:0000313|Proteomes:UP000283841};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 474..622
FT /note="Lariat debranching enzyme C-terminal"
FT /evidence="ECO:0000259|SMART:SM01124"
FT REGION 322..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 630..696
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..418
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..662
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..677
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 696 AA; 78034 MW; 4D2E646C246380DE CRC64;
MEPVNASRRG LRVALEGCGH GKLHDIYASV QEAAKLKGWD GVDLVIIGGD FQAVRNSYDM
NGMSVPKKYR QIGDFHEYYS GKRTAPYLTI YVGGNHEAYN HQFELYHGGW VAPNIYYLGA
ANVLRCGPLR IAGISGIFKG YDYRKPHFER LPYNDSEVHS AYHVRELDVR KLLQIRSQVD
LGLSHDWPKR VEYSGDHQAL FRRKPFLRED SISGKLGSDA AKEVLERLRP AYWFSAHLHV
KFAALVQHDD IAPGYTTADA KNAQAALQHA ASIERPAHAA EPVRDIGKPH SEKAQLSAWN
NFHAVAAKTD AEANAHFIER QRTERDAGVP LHSTEVNYQQ TWRKVNPDEE SGDRKILGIE
KTGYENDESA NKDENTVAEA STVKNSDEID LDLDDLSDAG KPGSAEAEEK KDVKMSDDLG
TPENSGPPLD VQAPGQGQIQ QVDGVDEVSE DLRRQLPASF ARPQQPQPPL NGPFPEAITN
KETRFLALGK CEPNQEFLQL TEFYPVSEQD GVQEERPFRL HYDKEWLAIT RVFADDLRVG
DRYAGIPPNK GDLFYKDQII EAEKWVEENI VQKGKLVIPE NFVPTAPFYD PAIPVITSEQ
PHEYNNPQTA EFCEMLGIEN KFYLTEEERD ARMAAGPAPD TSNRHHNNRG YGRDDSFGRR
GGRGRGRGGR GGRGGRGRRG RGGQGYDNPQ HYAGQW
//