ID A0A443HZ50_BYSSP Unreviewed; 952 AA.
AC A0A443HZ50;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE SubName: Full=Camp-regulated guanine nucleotide exchange factor {ECO:0000313|EMBL:RWQ97115.1};
GN ORFNames=C8Q69DRAFT_443518 {ECO:0000313|EMBL:RWQ97115.1};
OS Byssochlamys spectabilis (Paecilomyces variotii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX NCBI_TaxID=264951 {ECO:0000313|EMBL:RWQ97115.1, ECO:0000313|Proteomes:UP000283841};
RN [1] {ECO:0000313|EMBL:RWQ97115.1, ECO:0000313|Proteomes:UP000283841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101075 {ECO:0000313|EMBL:RWQ97115.1,
RC ECO:0000313|Proteomes:UP000283841};
RX PubMed=30619145; DOI=10.3389/fmicb.2018.03058;
RA Urquhart A.S., Mondo S.J., Makela M.R., Hane J.K., Wiebenga A., He G.,
RA Mihaltcheva S., Pangilinan J., Lipzen A., Barry K., de Vries R.P.,
RA Grigoriev I.V., Idnurm A.;
RT "Genomic and genetic insights into a cosmopolitan fungus, Paecilomyces
RT variotii (Eurotiales).";
RL Front. Microbiol. 9:3058-3058(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWQ97115.1}.
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DR EMBL; RCNU01000003; RWQ97115.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A443HZ50; -.
DR STRING; 264951.A0A443HZ50; -.
DR OrthoDB; 4819765at2759; -.
DR Proteomes; UP000283841; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000283841}.
FT DOMAIN 448..577
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 701..939
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 279..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 639..659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..446
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 952 AA; 106553 MW; 5D2AB007874FB70C CRC64;
MDAQQQSRRA RSSSDRAQGS PVTPPQRPRL GVRTISAPAG DIQKLDRSKG PAEEGKTFQT
TVIEESESPI TSPVDDRPID DDDVSTIKGN NQTSNSRANL PHVRLAVIGS KAVGKSTFVQ
CALDMKHLPT SHSNSKKMSL DGTVYMVRLL EISLDDISFD TNGSVVWPRT SDDNNLPPVD
GALILHDVTS PGGIIEASRL LSALTKSSIP YVLVQCKCDL QDRPQKMDAV TFEKMSRIIS
GKELHRTAAD SPRTQKRCIS ILLRSIVLKT PDIVRNHLYG NNSSSNSNSS STLRQTQVRQ
PLSPTQDWQN YTAAEAKETA REEASGSETI ASNERVDGNG ENRPTDKANG ASLALNAAGS
RYVRSNSHPV RPQTPPSAGR LDPRRPSVSS NAAESPPNRD NSRQRRLQPT WRHSAGSDAF
SSFLDMEDDE NGEHKNSPDR NKERPGEYVA ADTGVTFEDL VDRLVSVPMS KQDSKFSAIF
LCLYRKFAAP GTLLNALINR FEKTERSPAA QLSKSADQLR LLNVVGQWVS EYPGDFAYPK
TRRRLTDFVA ALEKNHVYMF AAKEIASYLD LIVEEDETGW PFRDSDSDAS EKSDRLETFL
NTSARSSPMA FLSGSSLLDY SIYNTSSLDL NDDIPDASSA HSGHSMSLSN ASSHGKSAST
SNQSFSTLIS VENAQREAQT LELTPKISLT KIQWRQFMEI PDDDFAKELT RIDWIMYNSF
RPRDLVRHVS ISSQDKDKIK SLANVNRMIK EFNHVAFFVA SMILFRDKPK HRAKALEKFM
NIAQRLRRQN NYNSLGAVIA GINGTPVHRL TQTRELVPLH VQKEFMRLVI LMGTQKSHFA
YRLAWENSFA ERIPFLPLHR RDLVSAEEGN KTFVGEDKSR VNWKKFEIMG EVVLGIQRSQ
KTPYPYIPKH EEVMRLLLET KLSNDEEDLY SRSMQVEPSA TGDRKKFAWL RS
//
