ID A0A443HZH4_BYSSP Unreviewed; 806 AA.
AC A0A443HZH4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=DNA repair protein {ECO:0000313|EMBL:RWQ97131.1};
GN ORFNames=C8Q69DRAFT_462445 {ECO:0000313|EMBL:RWQ97131.1};
OS Byssochlamys spectabilis (Paecilomyces variotii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX NCBI_TaxID=264951 {ECO:0000313|EMBL:RWQ97131.1, ECO:0000313|Proteomes:UP000283841};
RN [1] {ECO:0000313|EMBL:RWQ97131.1, ECO:0000313|Proteomes:UP000283841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101075 {ECO:0000313|EMBL:RWQ97131.1,
RC ECO:0000313|Proteomes:UP000283841};
RX PubMed=30619145; DOI=10.3389/fmicb.2018.03058;
RA Urquhart A.S., Mondo S.J., Makela M.R., Hane J.K., Wiebenga A., He G.,
RA Mihaltcheva S., Pangilinan J., Lipzen A., Barry K., de Vries R.P.,
RA Grigoriev I.V., Idnurm A.;
RT "Genomic and genetic insights into a cosmopolitan fungus, Paecilomyces
RT variotii (Eurotiales).";
RL Front. Microbiol. 9:3058-3058(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC family. {ECO:0000256|ARBA:ARBA00010304}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWQ97131.1}.
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DR EMBL; RCNU01000003; RWQ97131.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A443HZH4; -.
DR STRING; 264951.A0A443HZH4; -.
DR OrthoDB; 23465at2759; -.
DR Proteomes; UP000283841; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR011084; DRMBL.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR PANTHER; PTHR23240:SF39; REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04570)-RELATED; 1.
DR Pfam; PF07522; DRMBL; 1.
DR Pfam; PF12706; Lactamase_B_2; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000283841}.
FT DOMAIN 29..150
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF12706"
FT DOMAIN 425..463
FT /note="DNA repair metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF07522"
FT REGION 405..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 501..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..741
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 91022 MW; 68B9CE1E735F0692 CRC64;
MSTFDGIVEE FPFIRIDYFR KNPDRPSPLA CFLSHVHSDH LQGLESLRSP FIYCSAATRE
LLLRIEKYPH RMNFSKGILE SRKQHYNHLA KLLRPIPLNT PTEIELTPRL RIRVTLLDAN
HCLGAVMFLI EGDGKAVLYT GDIRAETWWV NSLIRHPVLI PYTLGNKRLN KVYLDTTFAI
KSDVYRSFPS KAEGIKELLD KVYAYPDDTV FYLRAWTFGY EDVWLALSAA LNSKIHVDRY
QRRLYQSLHP RNDGKVPEAA FLCGFELGNN FSPGCLTGDE SCRIHSCEPG MFCPVIASGR
AVYITPIVTR SDDVEVPEVG AGGGGGDLYQ SHELELPDES SVEQLEKLCL QHIHDPNILT
RTKGALIEAF RSKKKTLSLD RYGLKDENDI SLQRLVDVLS RGQSLDTTGS NQYEDKERAA
GGRTESKRQL PRKITFPYSR HSSYAELCEL IAAFRPKDIY PCTVDPETWS EDVSMARLFG
HLCSGDIFSH DEYMYKFLSE QQRPQQQMQD ISSSTQPSQQ SSEQSSQISH ALFSQPATGP
TEHDRVPKTH TRQLPTGPSS DSSHTRNDAQ PSNSTTTSLQ KSAAPTSEHH SPSMNHEPPP
IPERTEKARK HRNSIRRTWY KIEELRRQGK WHFHNEPLPT WWPTEEEDLY HAEEPSSDEA
SDVSDPDTPF LVTEDPSITD VNNIAPIDPI DTDVDADADA DLPYSQTSTL SISLSMSMSE
SAFDSQEQPP PPPPPPDSTP QTTPNINDSN NNRITNGSNG NNKRKRLPDP SIRNRIRAYH
AARSGSWSDV SLLSAGNNHT EEEQEL
//
