ID A0A443I8E8_BYSSP Unreviewed; 593 AA.
AC A0A443I8E8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Vacuolar protein sorting-associated protein 17 {ECO:0000256|PIRNR:PIRNR011791};
GN ORFNames=C8Q69DRAFT_454553 {ECO:0000313|EMBL:RWR00344.1};
OS Byssochlamys spectabilis (Paecilomyces variotii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Thermoascaceae; Paecilomyces.
OX NCBI_TaxID=264951 {ECO:0000313|EMBL:RWR00344.1, ECO:0000313|Proteomes:UP000283841};
RN [1] {ECO:0000313|EMBL:RWR00344.1, ECO:0000313|Proteomes:UP000283841}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 101075 {ECO:0000313|EMBL:RWR00344.1,
RC ECO:0000313|Proteomes:UP000283841};
RX PubMed=30619145; DOI=10.3389/fmicb.2018.03058;
RA Urquhart A.S., Mondo S.J., Makela M.R., Hane J.K., Wiebenga A., He G.,
RA Mihaltcheva S., Pangilinan J., Lipzen A., Barry K., de Vries R.P.,
RA Grigoriev I.V., Idnurm A.;
RT "Genomic and genetic insights into a cosmopolitan fungus, Paecilomyces
RT variotii (Eurotiales).";
RL Front. Microbiol. 9:3058-3058(2018).
CC -!- FUNCTION: Component of the membrane-associated retromer complex which
CC is essential in endosome-to-Golgi retrograde transport.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SUBUNIT: Component of the retromer complex.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- SIMILARITY: Belongs to the VPS17 family.
CC {ECO:0000256|PIRNR:PIRNR011791}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWR00344.1}.
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DR EMBL; RCNU01000001; RWR00344.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A443I8E8; -.
DR STRING; 264951.A0A443I8E8; -.
DR OrthoDB; 1708746at2759; -.
DR Proteomes; UP000283841; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0030904; C:retromer complex; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd06891; PX_Vps17p; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR014461; Retromer_complex_Vps17.
DR InterPro; IPR037907; Vps17_PX.
DR InterPro; IPR015404; Vps5_C.
DR PANTHER; PTHR47433; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR PANTHER; PTHR47433:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF09325; Vps5; 1.
DR PIRSF; PIRSF011791; Vps17; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR011791};
KW Reference proteome {ECO:0000313|Proteomes:UP000283841};
KW Transport {ECO:0000256|PIRNR:PIRNR011791}.
FT DOMAIN 128..242
FT /note="PX"
FT /evidence="ECO:0000259|SMART:SM00312"
FT REGION 1..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 593 AA; 65560 MW; 2D63C561DD36A3CA CRC64;
MDYSAINNDP DHPTGASPWD SPRADRTTFP ASVTSDIPPS PLPPQEQSPY GADQAAHPEE
SLKKTTDAED DESDSPDLSE RLQSAQLGDP DYVEQPPYAT RAQYSQHQKS QTPARYQTGA
RQHARQAPIW KLQAKITGLE RTGKKDPILR FDVHTNIPKF RTTQYRDVRR THSEFVKFAE
HLISNNPEAL VPAVPPPLTP AGAGTEEDEI RVKANMQRWL NYVCSNEVLV QDDETVLFVE
SDFGYSPVVR MKQPATGVRR KVLKQFAPPP DDTPELQNAR PVVKMFYLGA MDASQKVDRV
VKARRGLGLA ESDFGVKLGQ MHVQETHTGL ASAYRKLGRV IQTVGDYHAA QGTAEATTLG
DPLNYHSSDA FIVKETLTNR HILLRELIQA QQAARSKRAA ADRLKASSSV RPDKVDEAIS
SLDEALSHEN YLTKKTQRVT SHLLQEKRRW FDRTTNELLA SIREYTLRQI EAERRTLSTL
ESVRPDIRAI DSSGGLSRLG REAHPAARRA SLASSQGPKG DAWSGVPRRG DSLSRSITGS
YVAPVPDDEE VNGNGAGKGR VRALSGVGSI PEEDDDDRLD ARNAASRLAT STF
//
