ID A0A443QNP3_9ACAR Unreviewed; 910 AA.
AC A0A443QNP3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Tonsoku-like protein {ECO:0000313|EMBL:RWS04635.1};
GN ORFNames=B4U79_16356 {ECO:0000313|EMBL:RWS05027.1}, B4U79_16392
GN {ECO:0000313|EMBL:RWS04635.1}, B4U79_16401
GN {ECO:0000313|EMBL:RWS04587.1};
OS Dinothrombium tinctorium.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC Trombidioidea; Trombidiidae; Dinothrombium.
OX NCBI_TaxID=1965070 {ECO:0000313|EMBL:RWS04635.1, ECO:0000313|Proteomes:UP000285301};
RN [1] {ECO:0000313|EMBL:RWS04635.1, ECO:0000313|Proteomes:UP000285301}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UoL-WK {ECO:0000313|EMBL:RWS04635.1};
RA Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT transferred genes associated with secondary metabolism.";
RL Gigascience 0:0-0(2018).
RN [2] {ECO:0000313|EMBL:RWS04635.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UoL-WK {ECO:0000313|EMBL:RWS04635.1};
RA Dong X.;
RT "Trombidioid mite genomics.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Target cell membrane {ECO:0000256|ARBA:ARBA00004175}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWS04635.1}.
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DR EMBL; NCKU01005425; RWS04587.1; -; Genomic_DNA.
DR EMBL; NCKU01005387; RWS04635.1; -; Genomic_DNA.
DR EMBL; NCKU01005091; RWS05027.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A443QNP3; -.
DR STRING; 1965070.A0A443QNP3; -.
DR Proteomes; UP000285301; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0044231; C:host cell presynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0044218; C:other organism cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR46358; TONSOKU-LIKE PROTEIN; 1.
DR PANTHER; PTHR46358:SF1; TONSOKU-LIKE PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR SMART; SM00248; ANK; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023298};
KW Neurotoxin {ECO:0000256|ARBA:ARBA00022699};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Presynaptic neurotoxin {ECO:0000256|ARBA:ARBA00023028};
KW Reference proteome {ECO:0000313|Proteomes:UP000285301};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Target cell membrane {ECO:0000256|ARBA:ARBA00022537};
KW Target membrane {ECO:0000256|ARBA:ARBA00023298};
KW Toxin {ECO:0000256|ARBA:ARBA00022656}.
FT REPEAT 327..359
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 421..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 513..572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 518..532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 910 AA; 104652 MW; 3428D6D3F256A234 CRC64;
MEKELLNLER DKIKAKNSKQ YKEAAEICNY RGVLFASKGR FADALNEHNE ELHFCRLNRD
ILGESIACRK IGECYAEMEQ FDEALEKQMR YWKLAEKAND AVEVQRAWTT LGRTYFLQYS
SDTSNTQALS FAETATRKSL QVAEKLKTNS AIKEKDLNEM ICRSYLNLAL IYEANGNTEC
VECYLEAIKL AKKYNFKEDL YRCEMNLANF YLKTDPFYVH LLKLFDNAIK DAKELKNSAF
LCEAYLSKAK ALLLRTDYAG SCYCFKKAFF SQSPVEEDRE NARKCSKCVS RILRNLKELN
ESQSMQVKMD LCDKLADIND RGGQFCEGIT PLHDACINGH TNVIRVLLRK GANVTALDNS
GNTPLDCLKN CRSRLDNLSS SEEEDYDSVA RELENAMKKV GYDFKQSKSL KRRSFDLPFE
QNERDSISRN PNLSRKIHRK QKLTSTKSYC EENFVSEYEC AMMSLRRQND PGYDPKRRRL
SPTASYNVSP LLDESEVLID DWLIDDTGSS SKQALSMDRF RNKPRETLRS TGESSSRLRQ
NFTSCHISKD KNEERRKVDE SESDMIECES NTSDNDSTCD VNLLETCETV TESEMCPEIN
IDNQNYFSES NSVSTTSSSR TFEQNVSNKM SNFHVRVHIE GIILLINVTD KESTIRWLAE
ATSQRYYQMK QMKPTLSLKT RDGALLCFDD KIIDVLMDDN LQLDAIVELW ESQSPYERFI
DQCKFLKVTP QPELETILRM TSENGLLNLN HTLLPQNQLK PLLNAIKHQE IIDCVDLSYS
NILFIDRSSE FISTILSLPR LQQLNLECAG VTMSHLRVIS TSKSNVNQLN LSYNSLNDSN
SEILTQVFAK FAYLKKIDLR FCDFTSNLFT QSFLQSLEKS ALDEVLIDEF CKSEISDTNL
NSSKVRFCNI
//
