ID A0A443R111_9ACAR Unreviewed; 492 AA.
AC A0A443R111;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Glycine receptor subunit alpha-2-like protein {ECO:0000313|EMBL:RWS08943.1};
GN ORFNames=B4U79_17734 {ECO:0000313|EMBL:RWS08943.1};
OS Dinothrombium tinctorium.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC Trombidioidea; Trombidiidae; Dinothrombium.
OX NCBI_TaxID=1965070 {ECO:0000313|EMBL:RWS08943.1, ECO:0000313|Proteomes:UP000285301};
RN [1] {ECO:0000313|EMBL:RWS08943.1, ECO:0000313|Proteomes:UP000285301}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UoL-WK {ECO:0000313|EMBL:RWS08943.1};
RA Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT transferred genes associated with secondary metabolism.";
RL Gigascience 0:0-0(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWS08943.1}.
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DR EMBL; NCKU01002718; RWS08943.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A443R111; -.
DR STRING; 1965070.A0A443R111; -.
DR Proteomes; UP000285301; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945:SF925; PROTON-GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Ion transport {ECO:0000256|ARBA:ARBA00023286};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:RWS08943.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000285301};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023286}.
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..115
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT REGION 300..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 56703 MW; 06CA5F2CFA617BF8 CRC64;
MIDINVDGSS FTAEVELTQF WYDSRFDLNS TSIMRQYLVD EKHDQIWKPE IVFENAVNGE
LSANLFGSDL LVIASNGRVA RRVRAMVKFR CLMNLLQYPY DDHKCYIVLR SSEHKLRYCH
IHSPFLKPFS LEKVSIDCLV TKTNSCPTCL QFTVEYLRVE QICERFNVIE EELLRFSSCI
RIGLYFETRK TINYILRAFP SLVLIIIVFC SFLIPVTEHT SRVCSILVPF SGLMLMIDTN
ANFATAANIW IFGCTVFAFF AFVEYLIALF SVHLITNAVE EVERGYNEFL ESRYGKKEAQ
KPNLDAVKDP NGSKQTSSDQ SPLLPSQKTK QSLDKEAAKQ KTAEATDVIL KEQVDAKKVN
TKAGRKSYEK EVSQNKSAKT VGERENNAKL KANSNEEKWM NLMRSQKHLT VDRVSEIFEI
ASLKSRMRSG QRLMGAIEMR SHRKKKLSRN LPYSRLKLIW NLSYVPADIS ARISFPIAFA
LYAYFYFLIY IM
//
