ID A0A443R3A9_9ACAR Unreviewed; 969 AA.
AC A0A443R3A9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE Flags: Fragment;
GN ORFNames=B4U79_08156 {ECO:0000313|EMBL:RWS09764.1};
OS Dinothrombium tinctorium.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC Trombidioidea; Trombidiidae; Dinothrombium.
OX NCBI_TaxID=1965070 {ECO:0000313|EMBL:RWS09764.1, ECO:0000313|Proteomes:UP000285301};
RN [1] {ECO:0000313|EMBL:RWS09764.1, ECO:0000313|Proteomes:UP000285301}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UoL-WK {ECO:0000313|EMBL:RWS09764.1};
RA Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT transferred genes associated with secondary metabolism.";
RL Gigascience 0:0-0(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436,
CC ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWS09764.1}.
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DR EMBL; NCKU01002357; RWS09764.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A443R3A9; -.
DR STRING; 1965070.A0A443R3A9; -.
DR Proteomes; UP000285301; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001170; ANPR/GUC.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF335; GUANYLATE CYCLASE 32E; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00255; NATPEPTIDER.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000285301};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 495..757
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 800..852
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT NON_TER 969
FT /evidence="ECO:0000313|EMBL:RWS09764.1"
SQ SEQUENCE 969 AA; 110464 MW; 26D6EF6A6036CC8C CRC64;
MAGAIPLAVE HVNKDANLLP NHTLQFVPGD YMKPNTALAI RTMTRLLTDE NVVAFIGPDY
SCAEEALVAA AWNLPMIAYL DSRIIEENNQ CADTKVSNKS QYWTFARTLP PSSKVSKSLI
ALLKHFKWHK VVLIVADNPR DIQAQQELVT LAKKHNIQIT QTHSIPGKYL SRHNDTLKRI
IHKSYKRTRV YILLSETDVL IDFTRFMQAK VDIKEYVIIA VEDEDVYNST RKLRYFQHIF
ENLTLDSLDL FPFRAVLLIT SSAPSNPNYE QIQAEMRRKM TFPSLNIPTN PHIPHEIPIS
AGLAYDAVMI YAKAVTEVLR DGGSVRDGKT IIEHIIGSRY ESILGFSVTI DENGDAEGNY
SLLALIESSD STASMEPVGR FTYQNNQSLP SLYIERPIAW ISGHPPKAEP KCGFTGEFCV
TKPNWMLIGI CLVSGCLILI ASAFAFRYEH KLACLLWKVE MKDVLFIRRN SEYTLQNIRN
TVNLHKVNMN RYISYNVPPL ISNGGDESQT YEGHVRSNDC VGIYKGNVVF VKRINKKSID
LTRNVRKELI QMRELRHENI NPFIGACVDA NNIFILTLYC ARGSLEGMIY LHDSAFVSHG
RLKSSNCLVD SRWVLQIADF GLHEFKAGED ICPFMETKYE RDLLWRAPEL LRLVNPPPQG
TQKGDVYSFS IILHEIIGRS GPWGATNMDI NLILDRVMNP KKYGGRIFRP PVQKLKCPDY
VIRCMEECWH EDIDVRPDFR YINMRLREMQ RGIKPNIFDN MIAIMEKYAY NLEGLVQERT
NQLVEEKKKT ENLLLRMLPN TIQNFEIRHR PGERLKLRIG MHSGQCVAGV VGLKMPRFCL
FGDTVNTASR MESTGEALKI HVSNDTKVIL DKLGGYILQE RGLTYVKGKG EMRTFWLLGR
CESKKINVSQ LSKENNIAIP NEIIMQKSGK QLYRNSFSLD EKGIYEADTS VETISEDTNS
VENDALNDK
//
