ID A0A443RAP3_9ACAR Unreviewed; 497 AA.
AC A0A443RAP3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Sodium-dependent nutrient amino acid transporter 1 {ECO:0000256|ARBA:ARBA00040215};
DE Flags: Fragment;
GN ORFNames=B4U79_13490 {ECO:0000313|EMBL:RWS12348.1};
OS Dinothrombium tinctorium.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC Trombidioidea; Trombidiidae; Dinothrombium.
OX NCBI_TaxID=1965070 {ECO:0000313|EMBL:RWS12348.1, ECO:0000313|Proteomes:UP000285301};
RN [1] {ECO:0000313|EMBL:RWS12348.1, ECO:0000313|Proteomes:UP000285301}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UoL-WK {ECO:0000313|EMBL:RWS12348.1};
RA Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT transferred genes associated with secondary metabolism.";
RL Gigascience 0:0-0(2018).
CC -!- FUNCTION: Unusual broad substrate spectrum amino acid:sodium
CC cotransporter that promotes absorption of the D isomers of essential
CC amino acids. Neutral amino acids are the preferred substrates,
CC especially methionine and phenylalanine.
CC {ECO:0000256|ARBA:ARBA00037785}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Membrane
CC {ECO:0000256|ARBA:ARBA00004211}; Single-pass type IV membrane protein
CC {ECO:0000256|ARBA:ARBA00004211}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|ARBA:ARBA00006459}.
CC -!- SIMILARITY: Belongs to the syntaxin family.
CC {ECO:0000256|ARBA:ARBA00009063}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWS12348.1}.
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DR EMBL; NCKU01001350; RWS12348.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A443RAP3; -.
DR STRING; 1965070.A0A443RAP3; -.
DR Proteomes; UP000285301; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0005484; F:SNAP receptor activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd15845; SNARE_syntaxin16; 1.
DR Gene3D; 1.20.58.70; -; 1.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR037272; SNS_sf.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR11616:SF241; SODIUM-DEPENDENT NUTRIENT AMINO ACID TRANSPORTER 1-RELATED; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF161070; SNF-like; 1.
DR SUPFAM; SSF47661; t-snare proteins; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000285301};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 442..497
FT /note="T-SNARE coiled-coil homology"
FT /evidence="ECO:0000259|PROSITE:PS50192"
FT NON_TER 497
FT /evidence="ECO:0000313|EMBL:RWS12348.1"
SQ SEQUENCE 497 AA; 57022 MW; F2A29A44F0DAC110 CRC64;
MSVGLGNVWR FPHAAYSNGG GAFLILYLLL LFIIGRPLHY MQLILGQFSG RGPIKVWKCV
PALKDEVTWL NWRLCLCLIG SWILVYLSIS KDRSLGKAGP YIMNLPDNYG VGTATLSSCC
NDQLAYSGKY VGFIAPITLL AIFTYGNYQL ALNEKQDTDK GIPTWGLVIG WASAALAILK
VPFWILLTVL RCPGNWKQKI NRAFKPTPDW APIDPEIRHQ WYIWNLMKNE DQKQKYYINS
AFADCDEEKV NLINNGEAKF ERDDSDASDG PPSWLQLLNE FRFEANNIKK KISQLREVQE
SLLRSTLTAS SIFENDSDNN ANKEKEKEID LRSQEISRLI TQLHSLLVEI KTLRSLNPTS
KIIANILLFA NKEICDLSQN YRQSQRQYVN KLQSREKFSQ QFIINIDDCM DSSFDEFNNE
KLIETEEPKT LFKQTFVDAF DDKILKERER EISVILKSIN ELNQIFQDIN TTVVNQGTLL
DRIDFNIENV QSQVEEG
//
