ID A0A443RH56_9ACAR Unreviewed; 1749 AA.
AC A0A443RH56;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Intersectin-2-like isoform X13 {ECO:0000313|EMBL:RWS14578.1};
GN ORFNames=B4U79_03221 {ECO:0000313|EMBL:RWS14578.1};
OS Dinothrombium tinctorium.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC Trombidioidea; Trombidiidae; Dinothrombium.
OX NCBI_TaxID=1965070 {ECO:0000313|EMBL:RWS14578.1, ECO:0000313|Proteomes:UP000285301};
RN [1] {ECO:0000313|EMBL:RWS14578.1, ECO:0000313|Proteomes:UP000285301}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UoL-WK {ECO:0000313|EMBL:RWS14578.1};
RA Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT transferred genes associated with secondary metabolism.";
RL Gigascience 0:0-0(2018).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWS14578.1}.
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DR EMBL; NCKU01000681; RWS14578.1; -; Genomic_DNA.
DR STRING; 1965070.A0A443RH56; -.
DR Proteomes; UP000285301; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00052; EH; 2.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11837; SH3_Intersectin_2; 1.
DR CDD; cd11838; SH3_Intersectin_3; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 5.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46006:SF9; INTERSECTIN-2 ISOFORM X1; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12763; EF-hand_4; 2.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 3.
DR Pfam; PF07653; SH3_2; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00239; C2; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00027; EH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 5.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 5.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS50031; EH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Reference proteome {ECO:0000313|Proteomes:UP000285301};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 15..96
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 47..82
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 268..357
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 301..336
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 717..778
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 833..891
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 897..956
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1045..1109
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1131..1192
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1216..1406
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1445..1579
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1585..1725
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 402..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1014..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1109..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 621..697
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1109..1126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1749 AA; 197263 MW; 83201D59C04AB48F CRC64;
MLGAQKDPYF ITPDQKSKYE SQFFRLQPIN GLITGEQAKG LFLKSGLPPQ ILAKIWELAD
VDADGRMDVN EFCIALHLIA LKLKGIDPPN TLPQSLRVLV EPPRFDAFGL SSTASVPLST
MGMSTIPSMP GVASSIPGVV SSMPGVVSSM PGVVSSMPGV ISSMPHVPPS VPPPIPAFPA
GIDSHLVTSP VPPGRPPPPR TFDNQPSVVP SSLALNTATN TTMSTTSHQA IPVSIAMDSS
KLQRAGSITS GDYPASMMLT EWAIPQPSKL KYTQMFNTHD RTRTGFLTGP QARNILLQSG
LPQQTLAQIW NLSDIDADGR LTCEEFVLAM HLIDNVKAGD TLPVTLPPDL IPPSLRRKRS
LSGAGVVVPT SGALVGDLMG PVTEEVTLTA AGSKMSVNTF EDKRRENFEK GQAELDRRRQ
LLLDQQRREQ QERERKEREE AEKREKIRLE QEMRRQQELE KQLQRQKEIE AEKEEQRRKL
LEQREAARRE MERQRMLEWE NQRKQELQSQ KQRLLESISQ LKSKKTSLII EVEKVNNQWS
QVQEHVEETR KKVTDSKSEI DKMRVERDSK LKEINFLKTQ MKTLQDRQLL IEQDKLNLTS
QLKNVNINAV QGVTDSTQFA LQAKQLNINQ LKSQLEEIEK ERKHKLEDIE NSNSQLKEIM
NAYNAIVCKT KELQEIYNRK REEAQKLKEK TQQTVTQNQD FDAGWADSSG WVEEKTGNGI
QYRAIFAFEA RNHDELSVDV NDIVTVIPDP TAESGWVKGT CKGQTGWLPE AYLELLDETI
GTKTTFETTT EVKNGFDETN AFADNKDAFK PSKDSSFVAP TPKPTIKDSV SATGIITAVA
LYPWKAKEDN HLSFNKGDTI LVKEQQDMWW CGEINGKSGW FPKSYVKPLS ASGEKEPEPE
YYISLYPFET QEPGDLAFDA GELITVVKKD GDWWTGEIGS ERYGIFPSNY VREAHPEEVP
KPTEPIPPTS APAAPTATVA YDVSVVHFFI VHSPLYDLSK SCFFTYAYQT NQKKEPETAP
PQPGSVEASP IRSVDSPKLK KAKLKKPEVV KVIAAYKASG PEQLNLEKGQ LIQVRKKNSS
GWWEGEIQIK GKKRQIGWFP ASYVKSLTPG GSGSGGSSAR STPDPTKSES VESDKVIALY
SFKAQHDDEI SFEADDVIKV LSKDDAVWWK GQLLSTGAIG LFPSNHVQPY KEKRFSNVSY
SSMNGYQLDL SPRTVRRLNH IQELIATEES YVNDMEMVNH AFRTPLIESG VITRQEFDSI
FLNWNEIIKC NKKFLKALKS FKRKSNGNVE LSGEISHILC EHLSQMESVY TKFCSKQLSS
AQLLQMKFEN DANFNEIAKR CTFDFRTNSY GLPLSTYLMK PMQRITKYPL LIKKILENTN
EDDKDYENCK SALFYAQKLC DNVNEACRNQ ENEERLGWIQ NHVKFDGLDE RIVLNSETNF
MGARRLLFYG YLIKVNSNKE LLGFLFNDFL LLCEPLGKEI GKVNNLFASD KVLMSKYSMY
KKPFLLDDIE QVSCNSDSSS ISLHSSNSSS VAPIENYLSN ENPSVFVLGV KSLSRTLILK
ATSSNEKLAW VKNLSEAKSR YCDAQMIKNR FYTRVNSDAG IGRLFVTVVD AVQLTSKNCV
LNTFCIVSIG LRNKDQQSHR SVHLTKVVRC FPLSPIPADT QQRTFNAKWN DSMQFFLGNN
SLENYCLIIS CYEKNYFSPN RLIGKMELNL REIDEEIRQL PAGPLNKAYS MSGERVIYLK
LDLKIFNEQ
//
