ID A0A443S6Y6_9ACAR Unreviewed; 914 AA.
AC A0A443S6Y6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=B4U80_04979 {ECO:0000313|EMBL:RWS23299.1};
OS Leptotrombidium deliense.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC Trombiculoidea; Trombiculidae; Leptotrombidium.
OX NCBI_TaxID=299467 {ECO:0000313|EMBL:RWS23299.1, ECO:0000313|Proteomes:UP000288716};
RN [1] {ECO:0000313|EMBL:RWS23299.1, ECO:0000313|Proteomes:UP000288716}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UoL-UT {ECO:0000313|EMBL:RWS23299.1};
RA Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT transferred genes associated with secondary metabolism.";
RL Gigascience 0:0-0(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWS23299.1}.
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DR EMBL; NCKV01006727; RWS23299.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A443S6Y6; -.
DR STRING; 299467.A0A443S6Y6; -.
DR EnsemblMetazoa; LDEU008741-RA; LDEU008741-PA; LDEU008741.
DR VEuPathDB; VectorBase:LDEU008741; -.
DR Proteomes; UP000288716; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0048666; P:neuron development; IEA:UniProt.
DR CDD; cd00063; FN3; 1.
DR CDD; cd14553; R-PTPc-LAR-1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF531; TYROSINE-PROTEIN PHOSPHATASE LAR; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000288716};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 255..278
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..89
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 360..615
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 535..606
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 647..906
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 821..897
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 914 AA; 104642 MW; 477AC70D803610D8 CRC64;
MTLSWKQPTK LNPVRYKITY GAHKEFYDSQ GVLQELPFWK NTIYVNSNIT EHKIEGLMPF
TSYQVNVTAI PGDESFRPPA KITITTAMAA PKPMVKPDSL GSQNGQELIV MLPQASEEYG
PINHYYLVVI PDTPSKNPEE YTIEELSATP LEGNGPYIAG KFPRRSMPHT FNLGDNKKYG
GFINRRLKRH QSYKIFVRAV VDTHYKSLYT SSPFSDQLSL EMPPTRNVNS PPINAGSITG
PTVVNPVTAA DSSNLVWVVT IVFITILVSI LAIAIFIVKR RYFHSIPRRR QLLKTPAGET
TMKLLMNPSD PRELGTHPSD PVELRRLNYQ TPGMMSHPPI PVTELSNHIE RLKANDNMKF
SQEYESIEPG QQFTWENSNL ECNKPKNRYA NVIAYDHSRV VLQPLDNIPG SDYINANYCD
GYRKQSAYIA TQGPLPETVG DFWRMVWEQR SASVVMMTKL EERTRIKCDQ YWPSRGTESY
GVMHVTLTNV EEISTYTIRT FTLQRSGYID KREVRQYQFT AWPDHGVPDH PTPFLAFLRR
IKAINPPDAG PMIIHCSAGV GRTGCFIVIE SMIERVKYEN TVDIYGHVTC LRAQRNYMVQ
TEDQYIFIHD AVLEAVISGN TEVSARNLYN HIQLLTRVVP GENISGMELE FRKIASMKTP
PNKFVSANLP QNKFKNRLMN ILPYESTRVC LQPIRGVDGS DYINASYVDG YVYRNAYVAT
QGPLPETAED FWRMIWEHNS NIIVMLTKVK EMGRDKCHQY WPSERSQRYM YFVVEPITEY
NMPQYILREF KVTDARDGQS RTVRQFHFVE WPEQGVPKSG EGFIDFITQV HKTKEQFGQE
GPITVHCSAG VGRTGVFISL SIVLEKIQNE GTVDLFQTVR TLRTQRPGMV QTEDQYQFCY
RAALEYISSF DYAT
//
