ID A0A443SDC3_9ACAR Unreviewed; 1067 AA.
AC A0A443SDC3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Peroxisomal ATPase PEX6 {ECO:0000256|ARBA:ARBA00034811};
DE EC=2.7.1.30 {ECO:0000256|ARBA:ARBA00012099};
DE AltName: Full=Peroxin-6 {ECO:0000256|ARBA:ARBA00034920};
DE Flags: Fragment;
GN ORFNames=B4U80_11075 {ECO:0000313|EMBL:RWS25511.1};
OS Leptotrombidium deliense.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC Trombiculoidea; Trombiculidae; Leptotrombidium.
OX NCBI_TaxID=299467 {ECO:0000313|EMBL:RWS25511.1, ECO:0000313|Proteomes:UP000288716};
RN [1] {ECO:0000313|EMBL:RWS25511.1, ECO:0000313|Proteomes:UP000288716}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UoL-UT {ECO:0000313|EMBL:RWS25511.1};
RA Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT transferred genes associated with secondary metabolism.";
RL Gigascience 0:0-0(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13066;
CC Evidence={ECO:0000256|ARBA:ARBA00034440};
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase
CC pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC {ECO:0000256|ARBA:ARBA00005190}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
CC {ECO:0000256|RuleBase:RU003733}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWS25511.1}.
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DR EMBL; NCKV01003630; RWS25511.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A443SDC3; -.
DR STRING; 299467.A0A443SDC3; -.
DR EnsemblMetazoa; LDEU006529-RA; LDEU006529-PA; LDEU006529.
DR VEuPathDB; VectorBase:LDEU006529; -.
DR UniPathway; UPA00618; UER00672.
DR Proteomes; UP000288716; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004370; F:glycerol kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0007031; P:peroxisome organization; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd19527; RecA-like_PEX6_r2; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018485; FGGY_C.
DR InterPro; IPR018484; FGGY_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047533; RecA-like_PEX6_r2.
DR PANTHER; PTHR23077; AAA-FAMILY ATPASE; 1.
DR PANTHER; PTHR23077:SF9; PEROXISOME ASSEMBLY FACTOR 2; 1.
DR Pfam; PF00004; AAA; 2.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00674; AAA; 1.
DR PROSITE; PS00933; FGGY_KINASES_1; 1.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Kinase {ECO:0000256|RuleBase:RU003733, ECO:0000313|EMBL:RWS25511.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Peroxisome biogenesis {ECO:0000256|ARBA:ARBA00022593};
KW Reference proteome {ECO:0000313|Proteomes:UP000288716};
KW Transferase {ECO:0000256|RuleBase:RU003733}.
FT DOMAIN 142..273
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 403..541
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT NON_TER 1067
FT /evidence="ECO:0000313|EMBL:RWS25511.1"
SQ SEQUENCE 1067 AA; 118940 MW; F8788E862F0ADAC2 CRC64;
MCSHVPSYAK AVHISLVQSP NYVANVDYSP LLRMYFSIQR VVQNGDIISV DSKLDLSYFM
KLKLDFRDLW PIIYFKVVQV EGDGCLIDVD NSNLYQTGTT RSFIPSLMPD FYGASDLNVG
VFGKHIEYLR LLMFPYLSLL KLSAAILLSG DHGSGKSYVV KSVCKILNLH CFEVDINRIL
CDTASATETK MKLMFDKVYR YTPCVVLIEN LEILCTECSG VDVRVAECFN TNVKTFKNEL
PAIFVIETND PEVLLKSDYG SVFQHHMKLE SLDEDERLET LRLLLHKRLL SRNVDLEKYS
KELSGFVIDD LHVLVKKITA NAHRRMVLEV DSDKSEIEAY LTADDFKMSI KEMEKSHRED
IGAPNVPNVE WDDVGGLEDV RKEILETVRL PLVYKQLSDC GLRRSGVLLH GPPGTGKTLL
AKAVASQCGL NFLSVKGPEI INMYVGQSEQ NVRNIFQTAR SAAPCIVFFD EIDSIAPNRG
RSGDSGGVMD RVVSQLLAEV DGVHKNNHVF VIGATNRPDL LDPALLRPGR FDRLLYVGIP
EGTACRLKIL QALMRNFTLE DNFEMTKLEH QCPPSLSGAD FYNLCSSAMV NAIERCIYEI
EDKQVSEDDA KIIVQMSDFF DSIRLLKSAS ETFRFVLLVM VRDLGPLIGA IDQGTSSTRF
LVFAARTGEL VTYHQKEIKK IYVLEEWVEQ NPDDIYTSVL ETIAKVVEKL AALDIDVSAI
KAVGLCNQRE TTIVWDKSTG IALHNAIVWL DNRTKDIVDS ILDGIPGRDI NYFKHKTGLP
ISTYFSAFKL KWLFQNEKAV QEKLKEGKLL FGTVDTWILW KLTNNHLTDV SNASRTFLMD
IETLDWDEQL CKFFNVPMKI LPEIKSSGDH FGVIREGPLK GVPVSGVIGD QSSALIGQNC
LCLGQTKATF GTGCFIMQNI GSGSVQSALK GVPLEARHSL VTTVAFKFGN KPAVYALEGS
VAIAGAAITW LRDNLELIKS YDEVEPLAKQ VPDAGGVYFV PAFQGLYAPY WDPNASGTII
GMSQFTKKAH IMRAVLESIA YQTSDILSLM RRSDTGISVD GGMSAND
//
