ID   A0A443SIG6_9ACAR        Unreviewed;       914 AA.
AC   A0A443SIG6;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Exostosin-3-like protein {ECO:0000313|EMBL:RWS27321.1};
GN   ORFNames=B4U80_06532 {ECO:0000313|EMBL:RWS27321.1};
OS   Leptotrombidium deliense.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC   Trombiculoidea; Trombiculidae; Leptotrombidium.
OX   NCBI_TaxID=299467 {ECO:0000313|EMBL:RWS27321.1, ECO:0000313|Proteomes:UP000288716};
RN   [1] {ECO:0000313|EMBL:RWS27321.1, ECO:0000313|Proteomes:UP000288716}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UoL-UT {ECO:0000313|EMBL:RWS27321.1};
RA   Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA   Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT   "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT   transferred genes associated with secondary metabolism.";
RL   Gigascience 0:0-0(2018).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC       {ECO:0000256|ARBA:ARBA00004648}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 47 family.
CC       {ECO:0000256|ARBA:ARBA00010271}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RWS27321.1}.
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DR   EMBL; NCKV01002104; RWS27321.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A443SIG6; -.
DR   STRING; 299467.A0A443SIG6; -.
DR   EnsemblMetazoa; LDEU004719-RA; LDEU004719-PA; LDEU004719.
DR   VEuPathDB; VectorBase:LDEU004719; -.
DR   Proteomes; UP000288716; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:InterPro.
DR   GO; GO:0015012; P:heparan sulfate proteoglycan biosynthetic process; IEA:UniProt.
DR   GO; GO:0006486; P:protein glycosylation; IEA:InterPro.
DR   InterPro; IPR004263; Exostosin.
DR   InterPro; IPR040911; Exostosin_GT47.
DR   InterPro; IPR015338; GT64.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR48261; ACETYLGLUCOSAMINYLTRANSFERASE; 1.
DR   PANTHER; PTHR48261:SF2; EXOSTOSIN-1-LIKE; 1.
DR   Pfam; PF03016; Exostosin; 1.
DR   Pfam; PF09258; Glyco_transf_64; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000288716};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        25..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          231..487
FT                   /note="Exostosin GT47"
FT                   /evidence="ECO:0000259|Pfam:PF03016"
FT   DOMAIN          657..899
FT                   /note="Glycosyl transferase 64"
FT                   /evidence="ECO:0000259|Pfam:PF09258"
FT   COILED          104..138
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   914 AA;  105076 MW;  67A1D5F375BDDF20 CRC64;
     MAKICSLKIN ERTMIPLPSV RMQKVMVLLL VLLITVPFLT HYYISKVVIN SEKFGTNVVT
     NPSLKSITYN EYNWNDVEAL QQIANLKLRV KEIMRIRGSV SNELKSMESK RQSLLSEINS
     LSQKLDEIKG QLNRKQSELR RVHVSLEQAK FSQIEAYMKN PPFIAKPLPL LSDKVFTNEQ
     DLHFSKSLDA NSEQSTDSSN ACDMHRCFDY SKCSLISGFP IFHYRSDEED YIPSDSQIFG
     EHTNQVKADV FEALDNSIHT TSDASIACLF VVVLFHHRLE QSQLQSYLNN LAHWAEGRNH
     VIINLMPNID LIDIGVNPRK ALVIQSQFSK HSFRNEFDIV SVVANNNEQK FPSFSPSKRS
     YLASFRADFG ANSTTEYQTL ISILKTITRE SGDDIFKFEL NCSLSVCAKH EEILLESTFA
     LIIPNSNSIS SQYISETLIR MLRLGAVPIL IGGDYIKLPF HEVIDWRLAV IHLPVARVTE
     LHFILKSFND NDIFSMRRHG RLLYSRYLKD QKTIVNTILA VLRQKRLQIA APILSDEPSV
     PLFNKSFPMK YFDPLENMLN PDSMEPDENL GPIEPPFSSI SYQRNYSLTL CHSYELWNSH
     ELDPFNLYPY TPFDPILPSE AKFKGSTFGF RPIGGGSGGA GKEFSESLGG NVPKEQFTIV
     ILTYEREAVL IDSLLRLKGL PHLNKILVIW NSADHLPSPD LKWPDVGVEI KVIRAQVNSL
     NNRFKPYDEI ETEAVLSMDD DAHLRHDEII FGFRVWRESR DRIVGFPGRY HAWDASHSVW
     LYNSNYSCEL SMVLTGAAFL HKYYTYLYTY SMPSSIRRRV DEYMNCEDIA MNFLVSHITR
     KPPLKVTSRW TFRCPGCPVS LSEDDSHFQE RHRCINYFAE VYGYNPLLNT QFRADSVLFK
     TRIPHDKQKC FKFI
//