ID A0A443SJQ0_9ACAR Unreviewed; 740 AA.
AC A0A443SJQ0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=5'-3' exoribonuclease 2-like protein {ECO:0000313|EMBL:RWS27757.1};
DE Flags: Fragment;
GN ORFNames=B4U80_07355 {ECO:0000313|EMBL:RWS27757.1};
OS Leptotrombidium deliense.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC Trombiculoidea; Trombiculidae; Leptotrombidium.
OX NCBI_TaxID=299467 {ECO:0000313|EMBL:RWS27757.1, ECO:0000313|Proteomes:UP000288716};
RN [1] {ECO:0000313|EMBL:RWS27757.1, ECO:0000313|Proteomes:UP000288716}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UoL-UT {ECO:0000313|EMBL:RWS27757.1};
RA Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT transferred genes associated with secondary metabolism.";
RL Gigascience 0:0-0(2018).
CC -!- SIMILARITY: Belongs to the 5'-3' exonuclease family. XRN2/RAT1
CC subfamily. {ECO:0000256|ARBA:ARBA00006994}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWS27757.1}.
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DR EMBL; NCKV01001799; RWS27757.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A443SJQ0; -.
DR STRING; 299467.A0A443SJQ0; -.
DR EnsemblMetazoa; LDEU004281-RA; LDEU004281-PA; LDEU004281.
DR VEuPathDB; VectorBase:LDEU004281; -.
DR Proteomes; UP000288716; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004534; F:5'-3' RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.1050; -; 1.
DR Gene3D; 3.40.50.12390; -; 1.
DR InterPro; IPR027073; 5_3_exoribonuclease.
DR InterPro; IPR041412; Xrn1_helical.
DR InterPro; IPR004859; Xrn1_N.
DR InterPro; IPR017151; Xrn2/3/4.
DR PANTHER; PTHR12341:SF77; 5'-3' EXORIBONUCLEASE 2; 1.
DR PANTHER; PTHR12341; 5'->3' EXORIBONUCLEASE; 1.
DR Pfam; PF17846; XRN_M; 1.
DR Pfam; PF03159; XRN_N; 1.
DR PIRSF; PIRSF037239; Exonuclease_Xrn2; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000288716};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 2..38
FT /note="Xrn1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03159"
FT DOMAIN 99..550
FT /note="Xrn1 helical"
FT /evidence="ECO:0000259|Pfam:PF17846"
FT REGION 186..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..729
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:RWS27757.1"
SQ SEQUENCE 740 AA; 86573 MW; DF13763C5443BC2A CRC64;
VQEDYNPNLS HLLCGADADL IMLALATHEL HFTILREEFI PNQPRPCEIC GQYGHEMNEC
TGTERQEYQQ DILITEPGFI YIRISVLREY LKRECGYEYD LERFIDDFVF LCFFVGNDFL
PHLPSLEIRE GAIDKLLGIY KDIMPKGKCQ KRYLTHNGFV DLEQAQLILH RLGEIEDEVF
KRRQVDQRRF KQRQKRQRQQ RNQYTSYNVP WMRPEQIVSR GQQPDAFGNV KHEAGRLRNA
VMDSSNQSAA QQFKAMLKTS ETSESEPREG KRKHDEVDGS DSEAEDNVKL GSEGWKARYY
YHKFDCVEYT DLSRRIAHEY VLGLCWVLRY YYQGCPDWKW FYPFHYAPFA SDFVDVATVD
VKFDANAKPF RPLEQLMSVF PAASSANLPP SWRKLMMDSN SPIIDFYPSN FKIDLNGKHA
AWMGVALLPF IDEERMFKAL ETVYPNLTDS ETARNSLGSH LLFTSRQKSS IVSFVKSLKE
DDNTVGTTIN SSDFDGMFGS VKLHKKHSKK YVNTVCVEFY DPVYPPNFVF PARRLIGAIA
PPDVLKPEDF DNTQRNWKPV IGLQPSNQRA SLDIAGRRML HAARHNEQQQ PRNNFNSSYN
NNYNSSYNNN YNANRNTNYN SNYNPNYAAR RPPQQNYQNT RFNNPGTNQG YPSQQQPQRN
QDFRERYSQN EGSYRRPSPP SYNTVSDFEC PQTQHIPGPY NPYQQQRRPP QQSSQRYQQQ
HQHQQQMSTR EDPWARHRQN
//
