ID   A0A443SL78_9ACAR        Unreviewed;       625 AA.
AC   A0A443SL78;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=CSC1-like protein 2 isoform X5 {ECO:0000313|EMBL:RWS28245.1};
GN   ORFNames=B4U80_02688 {ECO:0000313|EMBL:RWS28245.1};
OS   Leptotrombidium deliense.
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC   Trombiculoidea; Trombiculidae; Leptotrombidium.
OX   NCBI_TaxID=299467 {ECO:0000313|EMBL:RWS28245.1, ECO:0000313|Proteomes:UP000288716};
RN   [1] {ECO:0000313|EMBL:RWS28245.1, ECO:0000313|Proteomes:UP000288716}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UoL-UT {ECO:0000313|EMBL:RWS28245.1};
RA   Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA   Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT   "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT   transferred genes associated with secondary metabolism.";
RL   Gigascience 0:0-0(2018).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC       {ECO:0000256|ARBA:ARBA00007779}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RWS28245.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NCKV01001492; RWS28245.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A443SL78; -.
DR   EnsemblMetazoa; LDEU003796-RA; LDEU003796-PA; LDEU003796.
DR   VEuPathDB; VectorBase:LDEU003796; -.
DR   Proteomes; UP000288716; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR   InterPro; IPR045122; Csc1-like.
DR   InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR   InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR   InterPro; IPR032880; Csc1/OSCA1-like_N.
DR   PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR   PANTHER; PTHR13018:SF153; RE44586P; 1.
DR   Pfam; PF14703; PHM7_cyt; 1.
DR   Pfam; PF02714; RSN1_7TM; 1.
DR   Pfam; PF13967; RSN1_TM; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000288716};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        128..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        409..431
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        475..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        514..539
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        559..578
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        590..609
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          87..153
FT                   /note="CSC1/OSCA1-like N-terminal transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF13967"
FT   DOMAIN          174..365
FT                   /note="CSC1/OSCA1-like cytosolic"
FT                   /evidence="ECO:0000259|Pfam:PF14703"
FT   DOMAIN          371..581
FT                   /note="CSC1/OSCA1-like 7TM region"
FT                   /evidence="ECO:0000259|Pfam:PF02714"
SQ   SEQUENCE   625 AA;  72749 MW;  7539047155F4EC79 CRC64;
     MVKQPSSHFD RHFHEMRDSG ILLSPSRLDS LHVKSSPIED DEASIDRSRF LRLTEENDED
     DEDHFDRFEK RAEYIKKYVD YSKPTEIQTE EIRKSTGNWL LDMFLIRDKD ILRKRGKDAV
     DYLTFQRYII IFLMVLTGIC LCIILPVNLQ GTEAYLMCHF SNTIDADNED TCKRTLLIKG
     IPEAFRSKGK IIREIQKYLP DVNITALQFV YDSRKLKKLL INHDNVLDAK YFCEEYFFNF
     GVHFEGRPYV LGLFGGLFCC CYCCPKVDGI NYYQNEQKQL EDEILEEYKH TLSDPKGLVF
     ITLETEDMAL RIIQFANLTR YKRYCCTNCC LDCIWCCKEC TKPNTYNTDL KCWDIQYAPF
     PDDIYCAYAI PLILVISGNL LQVFVRLLTE ELPHRTISAK NHSVMVRTFI FLVLMTVILP
     SLRLTSLITL LRKLVVERKI PITSITTGSG ALFTNYVIQS ALLSNALELL RVADVFQYFF
     FFIFFSLTIA EVKFTSEKVL SEIQFGVHYS RMMLVVFIVA TYSITTPIIT PFGLLFMVLQ
     HAIDRYNIYF VYNSSRIDVQ THSSAIIFFH ISLMIMQLRL LSVIELEAKA AALLIVIVLE
     VILFCVQLYN HYYYGIFSVS VFLIL
//