ID A0A443SLP6_9ACAR Unreviewed; 2163 AA.
AC A0A443SLP6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
GN ORFNames=B4U80_03820 {ECO:0000313|EMBL:RWS28447.1};
OS Leptotrombidium deliense.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC Trombiculoidea; Trombiculidae; Leptotrombidium.
OX NCBI_TaxID=299467 {ECO:0000313|EMBL:RWS28447.1, ECO:0000313|Proteomes:UP000288716};
RN [1] {ECO:0000313|EMBL:RWS28447.1, ECO:0000313|Proteomes:UP000288716}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UoL-UT {ECO:0000313|EMBL:RWS28447.1};
RA Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT transferred genes associated with secondary metabolism.";
RL Gigascience 0:0-0(2018).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWS28447.1}.
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DR EMBL; NCKV01001376; RWS28447.1; -; Genomic_DNA.
DR STRING; 299467.A0A443SLP6; -.
DR EnsemblMetazoa; LDEU003593-RA; LDEU003593-PA; LDEU003593.
DR VEuPathDB; VectorBase:LDEU003593; -.
DR Proteomes; UP000288716; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000288716};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 1449..1714
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1749..2152
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 291..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1048..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1584..1624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 475..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1600..1619
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2163 AA; 238592 MW; 3CE83E7C992820C6 CRC64;
MDCRMSVVRY YSKPYTILLR DAYCHVVLLD LDVGLCNLLM CSKMKLTTVV NLHVRHPNRG
NASASPAQLS IAFNFFVHGE STVCATIDVK QHQPIFQLTK NCFLTAQGPQ NGLNVILSPY
GLSGFLTGQS YKDSDPVVQR LLKEWKKFYP VNFNEKDIQH TTKRQHQMQL TSFHVECSDE
APLNNASSGA FPAVVEVVVA GIKMKYPSCY TYVTSDARRK LKSEVKMVAK SVKQTGNQEC
VTSTSSPRTT TDTFNDENEC KLRTPALSPR QPHVASPTYR IRSSACQEIN INRQNQKDTT
QSSATSGSSP CEDISVLARW DFSDPCLKTN CSCYRCKSKK QNLNSTKASN ISSNIQNSNC
GVNKKLEKNE KDKVHKNLKV STPFHKRIVS DDLMCEVDSL LHDRESSECV SAVSIGSVSA
QSSQQPKTPS CQVYKSPLGQ ASLPSIQSNA TTPGGTAVDS PRSVAPLVNS EGPASYGVFE
SNLSSVSPGT AKDESSGQLE STVGTPNASK ERSHLEQLLS PYHSVSSVKG VNLNPPEDSP
STTQWANAQG TNESESISGA GGQSCSITKS EPTMHTHPLI SQMNGFKRPL LPANPLEEST
QQRNCYLYDF TCTNVLTANW DLPPPKNRRV MNFTDSNNYG MKKDSVIDST LDMMHNKPKD
PYEFSEFDED CAAFKESNEE GTRNEVLIVN SAEAALNNGA ATPQTIKDSV KQNVTGDVST
MSPQTPVVFT RDEDLIVSYR DLEQIFDTSS GEESNDERFQ APSAPPNSSK GVVSHVNATD
DSIKGSKSGS GNNANSSSGI LGVAELTRMF PTPPSLEHNT APSPCNFFAG TDPTLIDDVS
VREKLDIYPS SPSLLETSKD WSYVYKPPLQ SHCITSSKYG PLQNIPIVPA VQLPPECNYK
PSSSQCLQNS AKSFQQSSQH CNTQPPGYFH HQPGTGIHNV NNQTLHSHQL QRMPLQSHFS
VAACPPTVAT NGGVVGGRIM RHPSTMRPVP PQMHFVNTQQ SYAAHYPACI GGERHAQNSA
TCSPQFPPVP YQVEAPLHQG STHMYSSYHS YHSSPHHGHS TPPINGNSSS LPPLSYDIQS
QQGSYLSTRS SLQDSNVTNL EAHSLLVNLV LSDSMLNLFK DHNFESCALC VCNTNIRGSD
VGVYLPDMLL PSGSEELQCK CICGFSAVSY RHRSAFAGLF YEDEIEITGV VYDPTEGRKR
KSLSLVESLN KSEDISEKEC AKSDNSLIDC DQPNSTLIDL LKSQCSTIFS SSSLLRKASV
YESIKKNNNN VQSSGIPVML NSTRVVTKNT FLMRSDSLLR SDSCEIAFMA LISGKQAIDG
HPSKLMLQQY NTSDRINIKA STLHEWPFSN GGVPSNNYQV IRLLRNLQPL LQEAVQKKPQ
AMWEVTYTVS GPLTWRQFHR LAGRGTDDQC EPQPIPSLLV GHDKDWMALS PFGLKYWEKL
LLEPYSVTKD IAYIVVAPDN GYILSHVKSY FKELSTTYEM LRLGKHCPIA KVLRDGIMRV
GKTTAKNLAD KPVDEWFNQI GDGNVASKLK MYAQACRHYV TPLLTAQSLE KLLCENFSSR
PLESTSNVST SNSTLPKIIS SSPVASESAS VHESKSNTEE STESVNISTS ASQQPTDSVE
QDDDPNKQAA VVIYIVEPFT FANMDDELYR LSCLGLMRCY IQMLKYIPEQ MQSHIHLQLV
SLDAVLGLGK DFLGSKRQDQ LKSLAISVFN QCRKIVSNQS ISKSLTGFGP AASLDIFLKN
KEMNTARIYT PPYILAPLKD KQTELVEISG DRREKSQTLF CAYCLSEDQR WLIVSCCNDK
GDLLESTCIN IEVPNRTRRK KASVKKFGLH KVMEFVLSVI AETLQPWRLI IGRLGRVGHG
ELREWAYLLS KKSLLRYSRH LREKCRQCSF MAPYDIPCIF SACLISLEAD TSLRVFPDQF
TPDDRFSNNS NNCQLSTPED ASCTHILVFP TSATTQSSQG TFPIDPLGPN IGEDDLLQAL
GADGDELGVD DGINDIFGWP ESPPVSPGVG SPRGPVPHLD KLDSTAACII RQNSSVIGGD
STEEPPQLQQ QPLALGYYVS TAQTGPLPKW FWSSCSHLEN ICPSALLIHT PSVQQSSDDL
YSNTRSNHPL DSDFTTDVLR YVLEGYNSLS WINLDPSTHD RMSCLPVHIQ ILMQLYHTVQ
ALI
//
