ID A0A443SMD6_9ACAR Unreviewed; 937 AA.
AC A0A443SMD6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Next to BRCA1 gene 1 protein-like isoform X2 {ECO:0000313|EMBL:RWS28643.1};
GN ORFNames=B4U80_12780 {ECO:0000313|EMBL:RWS28643.1};
OS Leptotrombidium deliense.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC Trombiculoidea; Trombiculidae; Leptotrombidium.
OX NCBI_TaxID=299467 {ECO:0000313|EMBL:RWS28643.1, ECO:0000313|Proteomes:UP000288716};
RN [1] {ECO:0000313|EMBL:RWS28643.1, ECO:0000313|Proteomes:UP000288716}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UoL-UT {ECO:0000313|EMBL:RWS28643.1};
RA Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT transferred genes associated with secondary metabolism.";
RL Gigascience 0:0-0(2018).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome
CC {ECO:0000256|ARBA:ARBA00004419}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWS28643.1}.
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DR EMBL; NCKV01001277; RWS28643.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A443SMD6; -.
DR STRING; 299467.A0A443SMD6; -.
DR EnsemblMetazoa; LDEU003394-RA; LDEU003394-PA; LDEU003394.
DR VEuPathDB; VectorBase:LDEU003394; -.
DR Proteomes; UP000288716; Unassembled WGS sequence.
DR GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd14947; NBR1_like; 1.
DR CDD; cd14319; UBA_NBR1; 1.
DR CDD; cd02340; ZZ_NBR1_like; 1.
DR Gene3D; 3.30.60.90; -; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032350; N_BRCA1_central.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR20930:SF2; NEXT TO BRCA1 GENE 1 PROTEIN; 1.
DR PANTHER; PTHR20930; OVARIAN CARCINOMA ANTIGEN CA125-RELATED; 1.
DR Pfam; PF16158; N_BRCA1_IG; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000288716};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00228}.
FT DOMAIN 241..293
FT /note="ZZ-type"
FT /evidence="ECO:0000259|PROSITE:PS50135"
FT DOMAIN 868..912
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 322..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 563..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 916..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 937 AA; 105387 MW; 7B3C4DD21BD88E5B CRC64;
MNSSAFTEPV KVIFTLPSET DFEGIKYRPL RIMPVSSNSL IGKHYSWDFI LKQFRSQNQL
EENKRINLQA KFASNGKIIP LNSVESYETA VKIAELHEDS FDVMIQPVID VSSDSENDAV
DNNNVRKNFK PSKLQSLKVE PQFTFAFPPF KSPFLLPKNS SETKINNSGF ENKMKSVRPP
WSHEMKQEIK NELKGEILDT LIAALQELKS KENAAEIKPA KVNQIDASDR KAPITEEKVV
HSNIICDHCE QEIRGIRYKC SQCADFDLCE TCENIKDAHA ENHIFQKIRK PMQKKVYSGE
DIILSLDVDL PTGRTEVKDI RFIPNQKKSS QKHKPTNFQE TSSDNDSCPV NVPKQFETNT
TTRDQSVRPK HIERKVAELN KKVEKLRFLG GTLISEETVA DGSSIQPGTK FKKVWKVKNS
GTKSWNSRTT VRFCWGNTEL EPFNKVKEFS VPPLKPGQEG RITIRFAISK SCSYGFYHSH
WRLHHRGQPF GQRLVCKVFV DPNDDKCAKG CNCTKCGYES KVKQKIVEFK ENGANLEAAL
TAVREIKFCD NCEEIPIKMN VKSHTTTPTN TPFDVSPPKS PEPTSLIALP DEPLEVPEEN
GNSQKCENEN VQKATDTDAF FENESLSAFS YSSSESSDEF VIVPLPRCFD LSTPFSCTER
VEISCKPNID LRLTLPDSGE TEEQIPLVAE PNTNDPLNYG TIPVKVETSQ SGVPQQNVDE
CLLNSPVEQN LLRDFSNDSS ASADVAEVLS IEKVDETVIK PEDSSPNKPS EPTARNINTN
PFLQAFMTPP QQSTENMIHV LPESIVNGAL NVAANVVHNG SNENYNWVTS PPPAAIPTAH
QFFETRNETG NQPEVPNATA EENGSAKSSQ SRLSKAMSQL FEMGFWNQQL NEELLEKHNF
DVNNAVEDLL SPHRQESFEV VSQQPRQVAP RGYTEFD
//
