ID A0A443SP05_9ACAR Unreviewed; 829 AA.
AC A0A443SP05;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=N-acetylated-alpha-linked acidic dipeptidase 2-like protein {ECO:0000313|EMBL:RWS29270.1};
GN ORFNames=B4U80_06415 {ECO:0000313|EMBL:RWS29270.1};
OS Leptotrombidium deliense.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC Trombiculoidea; Trombiculidae; Leptotrombidium.
OX NCBI_TaxID=299467 {ECO:0000313|EMBL:RWS29270.1, ECO:0000313|Proteomes:UP000288716};
RN [1] {ECO:0000313|EMBL:RWS29270.1, ECO:0000313|Proteomes:UP000288716}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UoL-UT {ECO:0000313|EMBL:RWS29270.1};
RA Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT transferred genes associated with secondary metabolism.";
RL Gigascience 0:0-0(2018).
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWS29270.1}.
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DR EMBL; NCKV01000989; RWS29270.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A443SP05; -.
DR STRING; 299467.A0A443SP05; -.
DR EnsemblMetazoa; LDEU002768-RA; LDEU002768-PA; LDEU002768.
DR VEuPathDB; VectorBase:LDEU002768; -.
DR Proteomes; UP000288716; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000288716};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 50..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 381..514
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 706..826
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
SQ SEQUENCE 829 AA; 94045 MW; 2C4BF8CDAF05B138 CRC64;
MSAQYRPYRD EDHCDGLEND NLNWGDNEPG SIQIYEKTTE DLPFSSNRRF VLSALGVTLI
TFVVGFVIGY FVHTNHAACI PNISVALHST KDEDTTISRK IIEKVNAENL RHFVKVFSNE
ARFPGSERDL FLVKQIENSF RQSHFDETEI KNYTVLLSVP DDDHPNSVEI IDIEGKTTLF
SHKIYDAKKK YVAFSAYSPA ANITGDIVFV NYGRAQDYQY LQDVYNISVE GKIVIAKQFH
LAADEQLLYA QEKNAAALLL YTEPGDYFDE KDAWNIPPDA IRSDSLLWNG LGDPQTPGIP
STESALRLPL NAINILPKIP VQPISIATAY ELLGLMGGKP VPKDWAGVFN FTYRLGAGFQ
NTSLKLRLQV NNKYVNRTIH NVIGYMKGHV EPDRYVILGN HRDSWVNGAI DAAGGSAVFM
ELINVFGELR SRGWKPRRTI MFCSWGADEY NLIGSTEWLE ENYKILYSRA VAYINADVVV
LGNGSITADA SPLLYNVLYN ATKEVPNPDT NDEHKTVYDK WLYTFPTMHN YSQLVVPITY
FKNNFIQEEV ADYHNEVFGG NEENEMIDDI ESPSLFRSYL NSATIQIRPK IRQLNTRSVF
TSFFSNAGIP SIEMTYVPFA SHEDADFFLH PLIHSQYDDF ELVDSVIDPS FKCHKAVTQV
IGEVIRDLSD SLFIPFNLLH YAQVLKDLSS ALHIKVLSNM KLKDINIMTL ESAVHNFTKA
ALNFHYHQEK ADLKDPMAIR RINDQLLLLE RALLHPSGLP RNRMKKHIIM SPSETSSPYD
DTFPGLMDEF AVLIESSFLA VQSWDILKKH FADLIYTIQT AANILNDMP
//
