ID A0A443SQX4_9ACAR Unreviewed; 691 AA.
AC A0A443SQX4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=B4U80_10531 {ECO:0000313|EMBL:RWS29917.1};
OS Leptotrombidium deliense.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC Acariformes; Trombidiformes; Prostigmata; Anystina; Parasitengona;
OC Trombiculoidea; Trombiculidae; Leptotrombidium.
OX NCBI_TaxID=299467 {ECO:0000313|EMBL:RWS29917.1, ECO:0000313|Proteomes:UP000288716};
RN [1] {ECO:0000313|EMBL:RWS29917.1, ECO:0000313|Proteomes:UP000288716}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UoL-UT {ECO:0000313|EMBL:RWS29917.1};
RA Dong X., Chaisiri K., Xia D., Armstrong S.D., Fang Y., Donnelly M.J.,
RA Kadowaki T., McGarry J.W., Darby A.C., Makepeace B.L.;
RT "Genomes of trombidid mites reveal novel predicted allergens and laterally-
RT transferred genes associated with secondary metabolism.";
RL Gigascience 0:0-0(2018).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RWS29917.1}.
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DR EMBL; NCKV01000716; RWS29917.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A443SQX4; -.
DR STRING; 299467.A0A443SQX4; -.
DR EnsemblMetazoa; LDEU002122-RA; LDEU002122-PA; LDEU002122.
DR VEuPathDB; VectorBase:LDEU002122; -.
DR Proteomes; UP000288716; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF136; ATP-DEPENDENT RNA HELICASE DHX35-RELATED; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:RWS29917.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000288716}.
FT DOMAIN 55..223
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 248..425
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 691 AA; 78131 MW; D32D00D942646FD3 CRC64;
MSNANFFKTL TDDGWKEEKT EAGETPSVVY NSFKGLEVSA QRFRLPIYEY RDHILYLLEQ
NQVLIVQGQT GCGKSTQIAQ YLSECNWNKG DDRMYLIGIT QPRRVAAVNL ATRVAAEMKC
ELGEQVGYTI RFEDCISRGK TLIKYMTEGI LINEMMGDPL LENYSVVIVD EAHERTLNTD
VVLGLLKKIL KKRPELRVIV SSATIETNSM QQFFASVAKT AIIRVEGRVF PVDVFYLNEP
AADYVKASIN AVIKIHENES SGDVLVFLTG QEEVERVVDI LFEYARSIKE RKNLKKMYVL
PMYASLPASE QLKVFESFPK SVRKVVVATN IAEASITIDG IVYVVDCGFV KLRFYNPKTC
TDSLVVVPIS KASADQRAGR AGRTRAGKVY RLYKEEHFEK LSLFTPPEIE RSNLSLTIVQ
LKALGINNIL KFEFPSPPPN QNIITALELL YALGAIDDSG SLTDPLGLQI AEFPLDPQYA
KMLLSSASFG CSEEALTITA MLQVQSVFQQ PSKGQRSIQA RNAKHKFSVE EGDLLTNLNV
YNAFIAAGKV RSWADKNYLN YKGMLRAVEV RQRLQSILNR FKVKLVSAKG DVDKVRKCIV
SGFFANAAYL HHSGVYKTVR GGHELHIHPM SVLYTRPRPP PWVLFIDVLH TSQEFMRELT
VIRSEWLYEL APHYYDYGTE REITERQLLT K
//
