ID   A0A444PT18_9MICO        Unreviewed;       393 AA.
AC   A0A444PT18;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Glutathione-dependent formaldehyde dehydrogenase {ECO:0000313|EMBL:RWZ51021.1};
GN   ORFNames=ELQ90_09490 {ECO:0000313|EMBL:RWZ51021.1};
OS   Labedella phragmitis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Labedella.
OX   NCBI_TaxID=2498849 {ECO:0000313|EMBL:RWZ51021.1, ECO:0000313|Proteomes:UP000288547};
RN   [1] {ECO:0000313|EMBL:RWZ51021.1, ECO:0000313|Proteomes:UP000288547}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=11W25H-1 {ECO:0000313|EMBL:RWZ51021.1,
RC   ECO:0000313|Proteomes:UP000288547};
RA   Li F.;
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RWZ51021.1}.
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DR   EMBL; RZNB01000003; RWZ51021.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A444PT18; -.
DR   OrthoDB; 241504at2; -.
DR   Proteomes; UP000288547; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          25..141
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          189..255
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
SQ   SEQUENCE   393 AA;  42279 MW;  F4E9C2F2B3A446CF CRC64;
     MKALTWQAKR NVSVEDVPDP RIEKPTDVVI RVTSAAICGS DLHLYELFGP FIGKGDVLGH
     ETMGVVEEVG PEVTRVKVGD RVVIPFTIAC GECYMCKRGL QSQCETTQVH EYGTGASLYG
     YTKMYGEIPG GQAEYLRVHR ADANCIVVGT ELPDDRYLFL SDILPTAWQA VQYANVPDGG
     SLGVYGLGPV GQFSARIGAY LGYEVYAIDP VAERRALAEK YGIRTFDSTK TVIEEIRDAT
     DGRGPDAVVD AVGMEAHGSP VAAAAHAAIG LLPDAVARPA MEKAGIDRLA ALHGALELVR
     RGGTVSISGV YGGEADPMPM KSMFDKQVAM RMGQCNVARW TPTLLPLAER DDDPLGTADL
     VTHRVPLAEA PHMYEVFQKK EDGCIKVVLD PAA
//