ID A0A444U0J4_ACIRT Unreviewed; 938 AA.
AC A0A444U0J4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=VPS10 domain-containing receptor SorCS2 {ECO:0000313|EMBL:RXM28698.1};
GN ORFNames=EOD39_2526 {ECO:0000313|EMBL:RXM28698.1};
OS Acipenser ruthenus (Sterlet sturgeon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Chondrostei; Acipenseriformes; Acipenseridae; Acipenser.
OX NCBI_TaxID=7906 {ECO:0000313|EMBL:RXM28698.1, ECO:0000313|Proteomes:UP000289886};
RN [1] {ECO:0000313|EMBL:RXM28698.1, ECO:0000313|Proteomes:UP000289886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WHYD16114868_AA {ECO:0000313|EMBL:RXM28698.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RXM28698.1};
RA Wei Q.;
RT "Draft Genome and Complete Hox-Cluster Characterization of the Sterlet
RT Sturgeon (Acipenser ruthenus).";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXM28698.1}.
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DR EMBL; SCEB01215591; RXM28698.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A444U0J4; -.
DR Proteomes; UP000289886; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0071840; P:cellular component organization or biogenesis; IEA:UniProt.
DR CDD; cd00146; PKD; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF9; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS2; 1.
DR Pfam; PF18911; PKD_4; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:RXM28698.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000289886};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 850..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 577..647
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
SQ SEQUENCE 938 AA; 105722 MW; 9F686B057BD1475A CRC64;
MLFISTDEGT NFQRQPLTFS VETLIFHPNE EDKLLAYSKE KRLYVSTDLG RKWTLLQERV
TKGRFFWSVA RVDADPDLVH MEMQDASGGF LYMTCLIQNC SDKMVTAQFL GKIDHNSLSV
QDDYIFVKVT TGNRTKHYVS YRRNEFVQMK FPKYALLKDV QIVSTDENQV FLALQEWYQT
DTYNLYQSDP QGVYYSIVLE NVRSTKQPEE NVLIDILEVR GIKGVFLANQ KVNGKVTTLI
TYNKGRDWDY LNPPSTDMNG KPVNCKPPDC HLHMHLRWAD NPYVSGTVHT KDSAPGLIMG
AGNLGSQLVE YKEEMYITSD CGKSWRQVFE EEHHILYLDH GGVIVAIKDT SIPLKILKFS
IDEGWTWMTH NFTSTSVFVD GLLSEPGDET LVMTVFGHIS FRSDWELVKV NFRQSFPRQC
TEADYDAWKL TNLKGEACIM GQERSFRKRK DSAFCIKGKS FTSALTSRPC QCTEKDFNCD
YGFERAASLK SEGDRCFADF WHDPDSPPDD CIIGHSYASS TGYRKVVSNI CEGGVNKQQS
SKQHTCPLLA PRGLQLGIKG ETMAVGPGDD ITFIVRQEQG DTVHTKYQVD LGDGFRAIYV
NLTVTDEPIQ HRYEKPGIYR VTVKAENTAG HDEAMVYIQV NSPLQEVHLE VVPIAGRNQD
VNLTAVILPV ATNLTVFYWW IGDNLQPILS LENSLITKFP NTGEVMVTVQ AACGRSMVQD
TKTMRVFDQF QVLPLTFSKS LDPFNPNIPD WREDIGQVVT RILAKITDIP QASLVTVVKA
DLPTTADLYV LPPESTPEKT SSTPVDKRIP AIKQALNGNN VSFIVRGGLV VFVNLADSDS
ESQRSGAGGG FWAMAVIFVV CLVAVGSFIL YKFKRKLPGR NVYAQMHNVK EQEMTSPVNH
SEDTQNIIQG EEFIDDDLDS QTLGLGSKLS FMKNRPCK
//
