ID A0A444UCZ7_ACIRT Unreviewed; 1030 AA.
AC A0A444UCZ7;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Solute carrier family 12 member 3 {ECO:0000313|EMBL:RXM33031.1};
GN ORFNames=EOD39_5758 {ECO:0000313|EMBL:RXM33031.1};
OS Acipenser ruthenus (Sterlet sturgeon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Chondrostei; Acipenseriformes; Acipenseridae; Acipenser.
OX NCBI_TaxID=7906 {ECO:0000313|EMBL:RXM33031.1, ECO:0000313|Proteomes:UP000289886};
RN [1] {ECO:0000313|EMBL:RXM33031.1, ECO:0000313|Proteomes:UP000289886}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WHYD16114868_AA {ECO:0000313|EMBL:RXM33031.1};
RC TISSUE=Blood {ECO:0000313|EMBL:RXM33031.1};
RA Wei Q.;
RT "Draft Genome and Complete Hox-Cluster Characterization of the Sterlet
RT Sturgeon (Acipenser ruthenus).";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RXM33031.1}.
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DR EMBL; SCEB01214811; RXM33031.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A444UCZ7; -.
DR Proteomes; UP000289886; Unassembled WGS sequence.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR013612; AA_permease_N.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002948; SLC12A3.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF9; SOLUTE CARRIER FAMILY 12 MEMBER 3; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF08403; AA_permease_N; 1.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01230; NACLTRNSPORT.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000289886};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 140..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 287..308
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 508..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..98
FT /note="Amino acid permease N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08403"
FT DOMAIN 143..648
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 657..790
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 825..1029
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 105..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1030 AA; 113997 MW; 819F328CA7E24C48 CRC64;
MADLPSHEVT VDAQFGNSRF TINRLMGTED SSRYRFGTPE LGAADTWDTN SSSQTNTFGY
NTLDAVPQYD HYANTMVKGV NRCHRPSLAQ LHTFIHEPDG FQPPKMYDPA DDAEGGEAVK
EGEEGESADK PPGEPVRFGW VKGVMIRCML NIWGVILYLR LPWITGQAGI GLTWVIVLLS
SSITGITGLS TSAIATNGKV KGGGTYFLIS RSLGPELGGS IGLIFAFANA VAVAMHTVGF
AETVRDLLRE YDSTMVDPTN DIRIIGVITV TILLGISLAG MEWEAKAQVL FFFVIMISFV
NYIVGTIIPA TPEKQSKGFF SYQAGIFSEN FVPDWRGPDG SFFGMFSIFF PSATGILAGA
NISGDLKDPA VAIPRGTMLA IFWTTVSYLT ISATIGSCVL RDASGNINDT IEMPPIGCEG
LDCSYGWNFT ECAKNHNCQH GLLNYYQTIS MVSGFAPLIT AGIFGATLSS ALACLVSAPK
VFQCLCKDNL YPLIGFFGKG YGKNDEPIRG YMLTYVIAVG FILIAELNTI APIISNFFLC
SYALINFSCF HASITNSPGW RPSFKYYSKW ASLLGAIISV VIMFLLTWWA ALIAIGIVIF
LLGYVLYTRP AINWGSSVQA SSYNRALSCS VGLNEVDDHI KNYRPQCLVL TGAPGFRPAM
VDLVGTFTKN LSLMTCGNVI IGPRKQKMPE VSRADRHVKW LNNRKSKSFY TGIVADDLRS
GVQILMQASG LGRMKPNVLV MGFKNNWKSD NPSNMENYIG IIHDAFDFNY GICLLRMKEG
LDISRTMQAH VNPGFEAGDD SHGNGSVAAY TVNGTLDPEA LVAEQQTTTV FQSQQGKKTI
DIYWLFDDGG LTLLIPYLLT RKKRWRNCKV RVFVAGQLNR MDEERKAFIA LLSKFRLGFN
DVQVLPDINQ RPQPENVKRF EDLLSPYKLN DDFKDETKIN ELKKDFPWKI SAEEIQKNMP
KSLRQVRLNE ILLDYSRDAA LIVMTMPIGR RSECPSSLYM AWLETLSQNL RPPVMLIRGN
QESVLTFYCQ
//
