ID A0A444WWS0_ARAHY Unreviewed; 1593 AA.
AC A0A444WWS0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=RING-type E3 ubiquitin transferase BRCA1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Ahy_B10g100490 {ECO:0000313|EMBL:RYQ81898.1};
OS Arachis hypogaea (Peanut).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC dalbergioids sensu lato; Dalbergieae; Pterocarpus clade; Arachis.
OX NCBI_TaxID=3818 {ECO:0000313|EMBL:RYQ81898.1, ECO:0000313|Proteomes:UP000289738};
RN [1] {ECO:0000313|EMBL:RYQ81898.1, ECO:0000313|Proteomes:UP000289738}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Fuhuasheng {ECO:0000313|Proteomes:UP000289738};
RC TISSUE=Leaves {ECO:0000313|EMBL:RYQ81898.1};
RA Chen X.;
RT "Sequencing of cultivated peanut Arachis hypogaea provides insights into
RT genome evolution and oil improvement.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PPR family. PCMP-H subfamily.
CC {ECO:0000256|ARBA:ARBA00006643}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RYQ81898.1}.
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DR EMBL; SDMP01000020; RYQ81898.1; -; Genomic_DNA.
DR Proteomes; UP000289738; Chromosome b10.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd17734; BRCT_Bard1_rpt1; 1.
DR CDD; cd15571; ePHD; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR031099; BRCA1-associated.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR032867; DYW_dom.
DR InterPro; IPR046848; E_motif.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR046849; Eplus_motif.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR NCBIfam; TIGR00756; PPR; 5.
DR PANTHER; PTHR13763:SF0; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF14432; DYW_deaminase; 1.
DR Pfam; PF20431; E_motif; 1.
DR Pfam; PF20430; Eplus_motif; 1.
DR Pfam; PF13041; PPR_2; 3.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR Pfam; PF13771; zf-HC5HC2H; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS51375; PPR; 4.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000289738};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT REPEAT 110..144
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 211..245
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 281..311
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 312..346
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT DOMAIN 623..661
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 1205..1324
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS51805"
FT DOMAIN 1395..1456
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1477..1593
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 719..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 830..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 919..943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..799
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 830..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 928..943
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1593 AA; 178968 MW; E2F65C96D535F79E CRC64;
MRLYSKFSSL VHTSQPLNPK IHLCSSTFLS SSSTTATQNP VPHIVTKCIA LLQFWASSIS
KLRQIHAFSI RHGVPLNNPD MGKHLIFTIV SLSAPMSYAY HVFAVLHDPN VFTWNTMIRG
YAESDDPSPA LHFYRKMSVS CVEPDTHTYP FLLKAVAKSL NVREGEAIHS VTVRKGFESL
VFVQNGLLHM YAVCGDTESA HKVFESMVER DLVAWNSVIN GFALNGRPSE ALTLFREMNM
EGLEPDGFTV VSLLSACAEL GALELGRRVH VFLLKVGLTE NMHVNNSLLD FYAKCGSIRE
AKQVFGEMRK RNVVSFTSLI VGLAVNGFGE EALEFFKEME EQRVKPSEIT FVGVLYACSH
CGMLNEGFNY FRRMKDEYGI MPRIEHYGCM VDLLSRAGLV KQAYEYIQNM PMQPNSVIWR
TLLGACTIHG HLGLGEIARS HLLKLEPKHS GDYVLLSNIY AAERRWSDVQ TVRRSMLEDG
VRKTPGYSMV ELGNRVYEFT MGDRSHPQSK DVYALLEKIT ELLKLEGYVP HTANVLADIE
EEEKEQALSY HSEKVAIAFM ILNTPPGTPI RVMKNLRVCA DCHMAIKLIS KNQNRFRPYL
ICQSSITMAN RTDLEEMGRE LQCPICLSLL NSPASLPCSH VFCNFCIVKS MKSSSDCPVC
KIPFFPREVR PSPRSLNLVN IYKRMERSSG MNLFLTQNPH HSKFSDEETQ CQTDADCVRE
DATRSHRNPA QKRKTLKNSV SGKENVPDTA KPSLPAKKRV QVPQDPLSET PFKNLSSGDS
LYGTRKEGKE KDTDTANENP LQSERDVPVL SPFFWLREEE GVENLSQQTF GDKLIDESPT
PSPPSFSDLK DSDDENPTKL TSDEVQNKTS FDLFDSELFE WTQRPCSPEL FSSPVKLQPL
SAGVISENQE DLLDASKELE RNKSSDYAEN TKLQNSENET RLSDVLQPSV TSPFRSSGDI
NGAKKYKKRS RKMREKAAQE QVVEQQDSIE GINVDSNRSL EITEDQSREK QQASNLGKTN
LKCKRVCFDT RTDSNISVVF RNGEVNMAKD SYISHSQKET NKLACQMIPG KCQSKRSGKQ
KLNYVQDQAE ELSCMQNQTD DELAGSASSM LSQQTDKNGK MSNKRQIKGK VFRKSISCGS
ELRSTKKLKL SSDFISQTKV GEQIQPNEST QRCPGVKVLD DTSKEKCSTW MHVPVLPNCE
SQAEKYQCVF CHSSEESEVS GPMMHYYGTK PVDANYEGGS KVIHSHRNCT EWAPNVYFDD
NAINLEAEIS RSRRIKCGFC GLKGAALGCY EKSCRRSFHV PCAKWTTHCR WDMENFVMLC
PLHTSCILPC ESSGSKGKSN KCRTRDSKSL AFKHGPTNQK GTALGSYKKI VLCCSALSIQ
ERDIVSEFQR VTKVTVLKKW DSSVTHVIAS TDENKACKRT LKVLMGILEG KWILNIEWIK
ACMKEMKPVD EESYEINLDI HGIHDGPHLG RLRVLNKQPK LFDGFKFYFV GDFMPSYKGY
LQDLVTAAGG VILNRKPVSG DANSTSPGMH PPQTLIIYNL ELPDKCSPSK RDTISTQRRH
DAEVLASSTG SKIASNTWIL NSIAACKLQI LAE
//
