ID A0A445AW54_ARAHY Unreviewed; 4251 AA.
AC A0A445AW54;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=PH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Ahy_B01g055420 {ECO:0000313|EMBL:RYR30668.1};
OS Arachis hypogaea (Peanut).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC dalbergioids sensu lato; Dalbergieae; Pterocarpus clade; Arachis.
OX NCBI_TaxID=3818 {ECO:0000313|EMBL:RYR30668.1, ECO:0000313|Proteomes:UP000289738};
RN [1] {ECO:0000313|EMBL:RYR30668.1, ECO:0000313|Proteomes:UP000289738}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Fuhuasheng {ECO:0000313|Proteomes:UP000289738};
RC TISSUE=Leaves {ECO:0000313|EMBL:RYR30668.1};
RA Chen X.;
RT "Sequencing of cultivated peanut Arachis hypogaea provides insights into
RT genome evolution and oil improvement.";
RL Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RYR30668.1}.
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DR EMBL; SDMP01000011; RYR30668.1; -; Genomic_DNA.
DR STRING; 3818.A0A445AW54; -.
DR Proteomes; UP000289738; Chromosome b01.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd00030; C2; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR InterPro; IPR009291; Vps62.
DR PANTHER; PTHR45523:SF6; SHR-BD DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45523; TETRATRICOPEPTIDE REPEAT (TPR)-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR Pfam; PF06650; VPS13_VAB; 1.
DR Pfam; PF06101; Vps62; 2.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000289738};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 829..939
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 2619..2768
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1202..1225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1202..1218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4251 AA; 475155 MW; 2FCF51B419F004AD CRC64;
MFEAHVLHLL RRYLGEYVHG LSQETLRISV WNGDVVLKDL RLKAEALNSL KLPVTVKAGF
VGSITLKVPW KRLGKEPVIV LIDRVFVLAQ PVPDRRTMKE EDREKLFQAK LQQIEELESA
TLDAISKSKS TSGNSWLSSL ISTVIGNLKI SISNVHIRYE DSVSNPGHPF SSGVTLAKLA
AVTMDEQGNE TFDTSGALDR LRKSVQLERL ALYHDSDRLP WEIHKSWEDI NPNEWIEIFE
DGINEPNDEK KVASTWGMNR TYLVYPINAV LQYHRLGNQE RVNPEIPFEK VSLVLSDVSL
TLSEAQYHDW IKLLESVSRY KTYMEVSHLR PAVPISEAPY LWWQFAAQAA LQQQKKCFRL
SWDQIRQLCQ RRRRYIQLYV ASLKQSSNVD HAEMREIEKD LDSKVILLWR LQARAKVESV
KSKVAADERK FRKKGWFSFK WRGDSEESSL DDASEGSEGT EETLTKEELQ AINNLLSYQP
DEESTKHSSK DMQNMIQHMV TVSVGQAAAR IINVNETEIV CGRFEQLHVS TKFRHRSVYC
DLLLKFYGLS APEGPLTESV HSEQKVNALA ASFVHLPIGE NIDWRLSATI APCHVTVLTE
SIDRVLEFVK RSKAVSPTVA LETATALQMK IEKVTRRAQE QFQMVLEEKS RFAFDVDLDA
PKVRIPLRSR GSARCDSHFL LDFGHFTLHT AESQSDEQRH NLYSRFYISG RDFAAFFTDC
GSDFGSCSLV KPTHDSQIIS SPRVKEADNV YSVIDRCGMA VLVNQIKVPH PSYPSTCISI
QVPNLCIHFS PERFRRIMEL LSILRKTMET CNQPTPDSLH SKLAPWSRDL VVDGRILVWK
GIGNSVATWQ TCFLVLSGSY LYVFETAESQ SYQRYLSMAG KQVLEVPPTN VGGSPFCIAI
SSRGMDFQKA LESSSTWILD FREEKEKARW FKRLIQATYE ASAPLSVDVL DDSNSDAACD
NVLNTSKKSA DIVINGALVE TKLLIYGKAG DTLDGKYGES LMLEVIADGG KMHLALANAD
LTMKMKLHSL KVKDELQARL SVTPQYLAVS VLKESVSSSP SALFDSHGKD ASLGFPDDDD
SFSDALSDFI SHVEGGNHLH NMDLDMQGGM GIASDFETLE SLIHEKEIEK GKNTPREVYY
EAEGTDNLHF VSVTFATRSS SSPDYDGIDT QMCVRMSKLE FFCNRPTILA LISFGLDISS
GNKGKSDTST IATSPEQTSM KKDKTDEKER VKGLLGFGKE RVVFHLNMNV DSVTIFLNTE
DGSQLATLVQ ENFLVDLKVH PSSLSICGTL GNFRLRDTCL GAEQCWDWLC DIRNPGVESL
IKFKFNSYSA GDDDYEGYAY KLQGQLSAVR IVFLNRFVQE IMVYFMELAT PRTEEAIKLV
DKVGGFEWLI KKHEIDGATA LKLDLLLDTP IIIFPRDSLS KNFIQLDLGM LQIKNEFRWH
GSREEDPSAV HIDILHAQIL GINMSVGIDG CLGKPMIREG QGFDIFVRRS LRDVFRKVPN
FSLEVKVDLL HVIMSDKEYK VILDCTCWNL REPPRLPASF RGGSSDSKDT IKLLVDKVNT
NSQQLLSQTV TIMAVVVNHA LLELCNGTGG ESPLAHVAIE GLWVNYRMTS LSETDLFVTI
PKFSILDVRP DTKPEMRLML GSSTDASKQS VTGKVPFALN TGSFRRTISD AGVDVDMPIS
TMFLMDCRWR ISSQSFVIRV QQPRVLVVPD FLLAVAEFFV PALGALTGRE ETMDPKNDPI
SRNNSIVLME SIYKQKEDVV YLSPSKQLVV DHVGVDEYVY DGCGKVICLS VETDTKEARN
IRFRPIIVIG HGKKLRFINV KIENGSLLRK YTYLSNDSSY SVSIDDGVDI VAPDILSSGD
EKSLDNMNQM SSTYTDSQSE SEMTRSFTFE TQVVSSELTF YDGTKSFLDD SSYGEKLIRA
KLDMSFMYAS KGKDSWIRTL VKDFTLEAGS GLVILDPVDI SGGYTSVKDK TNISLLSTDI
CVHLSLSAAT LILNLQSQAS AALSFGNATP LVQCSNYDRI WVSEKETGPN KNITFWRARA
PSNYVVLGDC VTSRPIPPSQ AVMAVSNTYG RVRKPVDFYL IGSLLKILGH DGPDGHSISG
SDCSLWMPIP PPGYVALGCV AHTGNQPPPK HVVHCLRSDL VTSAEYSDCL HNIPSNEQFT
SVFSIWRLDN AVGSFFAHFS TGRPLKDSCY DLNHLLLWNS NRAPLMDPFS SFNSDNEDIE
DTRKSVTTSG WDIVKSISKA ANSYISTPNF ERIWWDKGGD LRHPVSIWRP IARHGYAVVG
DCITEGLEPP ALGIVFKSDN PDLSSKPVQF TKVSHILGKG IEEVFFWYPI PPPGYVSLGC
VVSRTNEPPS ADLFCCPRMD LVSQANIHEV PLSRSSSSRA PQCWSIWKVE NQACTFLARS
DLKKPSSRLA YIIGDSVKPK TRENINAELK LRYFSLTILD SLYGMMRPLF DTTITNIKLA
THGGLEGMNA VLISSIVASA FNAKLEAWEP FVEPFDGIFK FESYDTNVQS EFGVGKRIRM
SATSILNVNI SAASLDTFVG SILSWRRQME LEEKASKLNM EAGDQQSKGE DTAFSALDED
DLQTVVVENN LGCDIFVKKV EHNVNTVDKL NHGDCASVWI PPPRFSNRLN VADESREARY
YVAVHILEAK GLSLIDDGNS HNFFCALRLV VDSQASEQQK LFPQSARTKC VKPVVSQISD
QDEGTVKWNE LFIFEVPRKA PAKLEVEVTN LAAKAGKGDV VGALSFPVGH GANILRKVAS
TRMFHQSYDV QSIRSYPLSK MVQQSNAEAI NEGFLFVSTS YFERNTIAKH QKDMESLNDV
DREIGFWVGL GQEGEWESIR SLLPLSVVPK SLENEYVAME VLMKNGKKHV IFRGLVTVVN
DSDVTLNILT SRSSHGIDPS PGAYSSNTVV EEVFQNQYYQ PSYGWSNNWP LTEHDAPGHW
STRDFSYSSK DFFEPPLPPG WKWTSGWSID KFQYVDKEGW AYGPDLKNLQ WPPTSSTFST
KSSSDVVRRR RWIRTRQNFS DQGKEYIQSG ASTLHPGAST VLPLRSTSKN SNHYLQVQPN
SNSSMPSYSW GCAVAVGSTY MYSKDQPVDQ SSRRNSATSN CSMNLNELEK KDILLCCNPS
SGSKQLWLSV GIDATVLNTE LNAPVYDWRV SVNSPIKLEN RLPCPAEFSI SEKTKEGHCV
EQHQGVVSSR QSVHIYSADI RKPLYLTLFV KGGWVMDKDA ILVLDPSFAN HISSFWMVHP
KSRRRLRLSI ELDMGETSTA PKTLRLFVPY WIVNDSSLLL AYRVVDVETL ENTEADSVVL
SRAAKSARTA LRNPISSLDR RHSNSRGNLQ VLEVIEDSSP FPSMLSPQDY AGHSGAAMFQ
SQKDAYLSPR VGLSVSLRHS EIYSSGISLL ELENKERIDV KAFNSDGSYY KLSALLNMTS
DRTKVVHFQP HTIFINRVGC SVCLQQCDTQ SALWIHPDDP PKPFGWQTSA KVELLKLRVD
GYKWSAPFSV SYEGVMRISL NKEAGGDPMQ LRVAVRTGAK KSRFEVIFRA NSLRSPYRIE
NRSMFLPIRF RQVDGTADSW QLLLPNSAAS FLWEDLGRRR LLELFEDGTD PMKSLKYDID
EVADHQPTQT GDGPTKAMRV TILKEEKINV VKISDWMPET EPAGVLGKRH LSAMSESQKQ
QLTSISNSEF HINFDLAELG ISIIDHTPEE ILYLSVQNLV LAYSTGLGSG ISRFKLRMGG
LQVDNQLPLT PMPVLFRPQR LVAEIDYILK FSVTMQSDGS LDLCVYPYIG LHGPEGSAFL
INIHEPIIWR LHEMIQVVKL GRLTDSQTTA ASVDPIIQIG VLNISEIRFK VSMTMSPSQR
PRGVLGFWAS LMTALGNMEN MPVKINQKFH ENVCMRQSSM ISMAVSNIRK DLLGQPLQLL
SGVDILGNAS SALGHMSKGV AALSMDKKFI QSRMRQESKG VEDFGDVLRE GGGALAKGLF
RGVTGILTKP LEGAKSSGVE GFVQGVGKGI IGAAAQPVSG VLDLLSKTTE GANAMRMKIA
SAITSEEQLL RRRLPRVIGG DNLLRLYDEY KAQGQVILQL AESGSFFSQV DLFKVRGKFA
LTDAYEDHFM LRKGKILMIT HRRLILLQQP SNVIGQRKFI PARDPCSIQW DIRWDDLATM
ELTHGKKDNP KSPPTRLILY LKSRTLDTKE NVRIVKCIPE SHQALEVYSS IDRAFHTYGP
GASKVTLAKN AKKPYSPHVE GSKFDLTLKE VTPGSTPVSS IFGSSSSRRY S
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