ID   A0A445BTU8_ARAHY        Unreviewed;       486 AA.
AC   A0A445BTU8;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   24-JAN-2024, entry version 13.
DE   RecName: Full=Protein DETOXIFICATION {ECO:0000256|RuleBase:RU004914};
DE   AltName: Full=Multidrug and toxic compound extrusion protein {ECO:0000256|RuleBase:RU004914};
GN   ORFNames=Ahy_A08g038475 {ECO:0000313|EMBL:RYR42026.1};
OS   Arachis hypogaea (Peanut).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   dalbergioids sensu lato; Dalbergieae; Pterocarpus clade; Arachis.
OX   NCBI_TaxID=3818 {ECO:0000313|EMBL:RYR42026.1, ECO:0000313|Proteomes:UP000289738};
RN   [1] {ECO:0000313|EMBL:RYR42026.1, ECO:0000313|Proteomes:UP000289738}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Fuhuasheng {ECO:0000313|Proteomes:UP000289738};
RC   TISSUE=Leaves {ECO:0000313|EMBL:RYR42026.1};
RA   Chen X.;
RT   "Sequencing of cultivated peanut Arachis hypogaea provides insights into
RT   genome evolution and oil improvement.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199,
CC       ECO:0000256|RuleBase:RU004914}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RYR42026.1}.
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DR   EMBL; SDMP01000008; RYR42026.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A445BTU8; -.
DR   STRING; 3818.A0A445BTU8; -.
DR   OrthoDB; 10858at2759; -.
DR   Proteomes; UP000289738; Chromosome a08.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR   CDD; cd13132; MATE_eukaryotic; 1.
DR   InterPro; IPR045069; MATE_euk.
DR   InterPro; IPR002528; MATE_fam.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR   PANTHER; PTHR11206:SF130; PROTEIN DETOXIFICATION; 1.
DR   Pfam; PF01554; MatE; 2.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|RuleBase:RU004914};
KW   Reference proteome {ECO:0000313|Proteomes:UP000289738};
KW   Transmembrane {ECO:0000256|RuleBase:RU004914};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU004914}.
FT   TRANSMEM        75..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        123..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        159..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        189..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        216..240
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        261..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        338..362
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        382..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        411..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
FT   TRANSMEM        440..462
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004914"
SQ   SEQUENCE   486 AA;  52976 MW;  1B0984CFF59DB17F CRC64;
     MVGSNSRSGT IIINEEESPL LHQPHDEATL IQRTCSESNS LWQIAAPSIF TRLAMFSITV
     VTQSFAGHLS DIDLAAFSIS CTVLISITFG FLLGMASALE TLCGQAYGAR KHHMLGIYLQ
     RSWLVLFFSS LFMIPIFVFA SPILKFIGQP SAVAERTGLV AIWLIPLHLS FPFQFSLQRF
     LQCQLKTRVA AWMAGVSLAI HVAVSLVFVS KMKVGIVGAA LSIGFSWWVS VVGMLSYTLF
     GGCKDTWTGF SSEAFLGLWE FFKLSFASGI MLLLENFYYR LLLIMSGYMD NSEVAIDALS
     VCNTIYAWES MIPLGFLAAS GVRVANELGA GNAKGAKFAT AISLLNTVVV GFIFWLIIMI
     FNENLALIFT SSSAIVQMVN ELSIMLAFTI LINCLQPVLS GVAVGCGNQA IVAYVNIASY
     YLMGMPLGIL LGWLLPSGII GMWTGMLSGT VGQTLILIVI TMRCDWDKKV LKAQILVKEK
     ALVSNQ
//