ID A0A445GCH2_GLYSO Unreviewed; 5079 AA.
AC A0A445GCH2;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=D0Y65_042293 {ECO:0000313|EMBL:RZB58912.1};
OS Glycine soja (Wild soybean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC Glycine subgen. Soja.
OX NCBI_TaxID=3848 {ECO:0000313|EMBL:RZB58912.1, ECO:0000313|Proteomes:UP000289340};
RN [1] {ECO:0000313|EMBL:RZB58912.1, ECO:0000313|Proteomes:UP000289340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. W05 {ECO:0000313|Proteomes:UP000289340};
RC TISSUE=Hypocotyl of etiolated seedlings {ECO:0000313|EMBL:RZB58912.1};
RA Xie M., Chung C.Y.L., Li M.-W., Wong F.-L., Chan T.-F., Lam H.-M.;
RT "A high-quality reference genome of wild soybean provides a powerful tool
RT to mine soybean genomes.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RZB58912.1}.
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DR EMBL; QZWG01000016; RZB58912.1; -; Genomic_DNA.
DR Proteomes; UP000289340; Chromosome 16.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 6.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR PIRSF; PIRSF010340; Midasin; 2.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 5.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000289340}.
FT DOMAIN 4867..5066
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 4227..4253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4270..4289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4301..4617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4697..4729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4230..4244
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4301..4326
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4335..4381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4387..4408
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4439..4458
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4459..4475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4488..4515
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4516..4588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4592..4617
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4699..4717
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5079 AA; 578709 MW; 9F3A311E6A724BE5 CRC64;
MAAASGWRRQ LAADDRQSQN SHSVLWRRVM IPPLNNKDLQ EIIKVRHPDL ELHVGKLIET
FERVNSISMV QIAGFHLGSS ASVYCPCRFS LRDLLKWCKR IAGLGFCFDG SLSENQCFCV
YKEAVDVFAS FSSSIKNRLS VMKEIAGLWK VPVSAAETLY PCDKPIIQDS FTDLRIGRVS
LQYSKPHLQQ HKRPFVEIRS SMHVLERIAC SVKYNEPVLL VGETGTGKTT IVQNLALRLD
QKLTVLNLSQ QSDVADLLGG FKPMDAQSVY VSLYGEFLSL FTKTFPKENN DGFITRMQNY
LEDHRQKFLI DKNGEALLKR LQIAVGKSVK LIQPGSSKKR KRPLEEKLIQ EWERFCIKLH
SVCQSNRSSA MMFSFVEGSF VTALRNGDWV LLDEVNLAPP ETLQRIIGVL EGEHGVLCLA
ERGDMDYIHR HPKFRIFACM NPATDAGKRD LPFSLRSRFT EYFVDDVLDD DDLSLFISQF
ISSAYMDQQL VNKIVCFYKE AKKESEERLQ DGTNQKPQYS LRSLYRALEY TRKAERKFKI
QKALYDGFSM FFVSLLDGSS AEIMRQKISS LLLEGKMPPH VHFSHYLDTS KSNGYSGNYV
QTKSVQEHLG NLARAVLMRY PVLLQGPTSS GKTSLVRYLA AITGHDFVRI NNHEYTDLQE
YLGSYITDTS GKLVFNEGVL VKAVRNGYWI VLDELNLAPS DVLEALNRLL DDNRELYVPE
LQERIKADPN FMLFATQNPP TLYGGRKMLS RAFRNRFVEI HVGEIPDGEL STILSERCQI
YIGHAEKMVE VMKDLRLHRQ SSRVFAGKHG FMTPRDLFRW ADRFQRFGNS YEDLAKDGYY
LLAERLRNED EKSVVQKVLK KHLGVTLNKK NLHDQISFRG HSSCNFNVGL GGSESLESVL
LTKSMQRLYF LVERCYNLRE PVLLVGETGG GKTTVCQLLS ACLQLKLHTL NCHQYTETSD
FIGGFRPIRE RSTLISNYKE IVEKLKKLKA YTYFSKDFSV SSDINHASST LDLLNGMIRN
CKEGQVFSPD VSGEDLNVLE QIKLDLNGLH QKWQSIFVWQ DGPLIKAMRD GDLFLVDEIS
LADDSVLERL NSVLEPERML SLAEKGGSDL EKVTAHSNFF VIATMNPGGD YGKKELSPAL
RNRFTEIWVS PVNDLHELRD IALKRISKFK VVGNSGPTNE ERLSLVNAMI SFFENNHIVN
TRNTPHSHIR DSYTLGNPNR VRLLHSNGIA RVEEVAFQRN ERNDDRLKRK ILEVDFAKAW
RRRRMNNEVC EATRILRARL VTLSLKIGQG SMWYNKLHPG RMLTVRDLIS WVDFLIAMEE
SLGPKRALLH GVFLVLLDGL NLGTGLSKRD AAELRERCLS ILLQKLGVDE SNSELSRIGN
YGWGEFGTDM DVSHSDDLFG IDPFYINKGI GICEDGGFEF KAPTTCRNAL RVLRAMQLPK
PVLLEGSPGV GKTSLIIALG KRSGHRVVRI NFSEQTDMMD LLGSDLPVES DEGMKFSWSD
GILLQVDLSY DALKEGCWVL LDEINLAPQS VLEGLNAILD HRAEVFIPEL GNTYKCPPSF
RVFACQNPSH QGGGRKGLPK SFLNRFTKVY VDELVEEDYL SICESKFSTI PRTLLTKLLL
FNKRMHEDTT VNQKFAKDGF PWEFNLRDVF RSCEIIEGAP KYSGLYSFLN IVYIQRMRLA
ADRKEVLRVF KEVFEVTPFI NPYPRIQLNS HHLIVGNVTI KRNHVQLTTS SSKQLLMLPE
IRQSLESAAR CVERQWLCIL TGPSCSGKTS LIRLLANLTG NVLNEVNLSS ATDISELLGS
FEQYDALRNF SKVVAQFECY VNEYISLQLE TSNEAIFRET DFYIRWMAFL SGLKFDCLSS
SAANCFENLC FLIGQLKLQI QKNSVPVSYS FHELDLAMKT VLKMKADVVS TKFEWVTGLL
IKAIEQGEWI VLENANLCNP TVLDRINSLV EPCGSITVNE RGIVDGNPLV IHPHPNFRIF
LTVNPHYGEV SRAMRNRGVE IFMLQPYWLD DRSGYNDEDV EFKDVRRFLV LSGIPIAQLV
DSMARAHTYA KNKGSELNEH ITYLELSHWV HLFLQLLKNG CCPIWSLKIS WEHIYLSSLG
VEGEKIIDFA KTKYLSATNL AGYDDLTACP LALPGGWPLP LSVRDYVYYS KEASIKQNCM
YLEFLGTQIA SHQYRIARKR HSTACVQTPS DHVRAYLMDM MTLRELMFPK ASNVMISDYG
RECKYDSELT NRMLFFAANW TIEQATESDF KFYLLRFKWF SSQMQPFCQF FSNFVILIEQ
MIKHPIWEYI SCRDKLDADL KLMPLLSLDL VDLAPSNSKI KYLCNAISCF DPLRLTYQQR
NIESQHNFDE EVSIESQHSF GEKTSCFIRL LKSLYFLQDE ILNKFVISTP KLIEDQSFDY
KLQLYSNLIE DHALFWHYFI SSEFDHMMIS WHCLVKDARK FIDMCPEAVD NFLMESQKIE
EFSFSVNSEK SLLWIHGGHP FLPSSSDLLD QQHQLLKFVE TIWPRKTGSC YQGILSSHLT
DVVASFDHDL RFLVTQDVSN SSFLMAKWNH EDGIHIVEKL KEMHQILSRR FEHEKHKLQL
NTGSKDLSAF AENSAACCSF TPVMLCEKSV FEAWQDTFLP VDYTSLFWDM KLLQKLTSIH
LDDLEELHQA VGCVSNLLDF ALKFSLSFSS RPPQMFLPHQ KILWTLNAWA SVDSVNLKIA
SFILEMWFKW HESIWVYFPK SVKIDGSDEI ELPHMLVEPF SALAVFQMTQ STHAIKEFWV
QCLKSRVTSF NLWHCSHHGT HLPDFLLSAA RCLFQQIIYA HRKSFEADQF ARIKYIFFSE
KNVLTEESID LLSSLVASSR HHRLKNSVQK FIVPLLRELY LQSNTADFNY TIGCAWAHVG
ALRINLLLSC KDIDPAMKYY CKYSQLVETI SSLELEIQVR KECGYLAGQV LTQEADKRKA
QRLEKLQAEC RKLQRKIVFR AEPSKYKKLI DVCMDFLKQH DALEVLVKSR GTAKELQEFV
DDACSWQETA TSFIHQLMDE YAAYSDIIQP IQVAVYEMKF GLSLVLSSTW EKKCLNELGQ
EDINVIMEMI YTLMRFPRAA SCMFISVKHD IGLDMRPSYR LDSATGFYLV DVDLMVRLVT
LSSGVAADQK VSGVHYRASV YWNILVQIAH CTANAKIIDD KSYMLMHKIF NVFAKLWLNK
KDDVKSESDF NSQQYKFKPR AFEIESVIEV ELPPLANSVA PETFLEWKEK SSDKVILIVP
SQDEKPKQLE ESIPFLSHVV LIHNRLFGSS DLVQTPGIFE VSDEDRLHSF IDSYTLGINL
IRGVHSTHLP SLDAKLMPEH LFYLCLDYRK KYLLSHKSAT RYNFYKDSNA SEMAQMLKVL
APLQQQILSV LNEWEDHNDL QNFLDIIDML LTLPSDTPLA KAFSGLQFLL HKAEVMQENG
SKFSFSNQFK SVYDLLSSWQ KIELDSWPAL LDEVMDQYEN NAGEHSIYDG GLIILTICPL
LCGFLCTLFF NTAHVIYQLF KGILEEFIQT SSIGEFRKRL QILFAFLGQN HISACLKINS
SSSQSEQSTF LYNIFGFYAQ FLPIVLKCID ASRKEVEIEL SKLVKLCRWV HGKSYLSIES
LKKGRQKLKK LIQKYTDILQ EPVSIFFSQE VAQRGAKVQS FHGHQPIYDV LNKGLVDGAF
DLTFFGENRF TWFDNCIKGV DSALQNLLLK KSVEEIQSIF RPCGDSQHTI YLKGWKAVWH
TIEKIYTTAV DYGDLWKEEK KGQGKRRALS ELLKLLESNG LSRHKSAYTA DQHKSWWFLQ
LSGNIPYLLL TNSRLSCVTS GIPEVENKNS PEESFLMEWK TAIDYYFKSV VSVLLLQQTC
LNPHKDITLE QVDSSSSFLN QLVQIQQKQL TAATAFDKQL KCFRECVSTL GKLFSLSSST
DNNINHMCSI IPKQFASYKC LWQQKQLFDT LCSTSQEELL LLRILENSHL NTCHRARPLA
RQMIASIEEF LPLFCKSKES LDCYLIGRTK AVTAVTYSSH LCIVTQEIEQ LVSENFKTIR
DFKDRFLELQ EHDLDRSTAR KVLIQHFQEI ADKAKLVEEE FTMAIKGNSN QVDLSEDIFC
ERNSVELNAR FNEALMSTCQ HLATVLQNLC LPSNIPMVDE SMVKIVSWES LFESFVTNLS
LDILCQNLFK AISFGEKLVN CCDDNNNSYL HVEAHFRNLH LLMDQLLNFG DELMKNFLAM
HKSVSVTTHV IANILASLFS KGFGISPENQ EEDGTLNTSG DASGTGMGEG VGLKDVSDQI
TDEDQLLGAR EQQNEKQDDS NEVPSSNNTG IEMEQDFEAD AMSLSEDSGE DDDIDGENEE
LESEMGPAGP DSEAVGEKVC DENEDETPND TREKYESGPS VKDRDGGNRE LRAKDDSTTN
EPGDGNCDEG DAQDDETVTP DEIGDGENAD EVTMDKDTAY SDPTGLKPDV LDQTSDTVMD
LDVNEDADLM EDGEPDEQVD LAENRNEGNR DEETCSPDEV MEEANTEVDV NSGKDDQENA
DLNSTEPKKD VSRLSELNNE QVSPAELASQ SKVDWQTSGS ENVAAESNVS NSHHDFDSTL
LGGLPSSSMS DMDVEMPNSS NSGGFGENQP KSHHPWTDHS FIQEKHTNPR RSIGDALEYK
KERVNVSGDV PEDNNEMQGE MEDENADEYG YVSEFEKGTT QALGPATLEQ VDRNIDCDKL
DKECLAGEDA KLQFEKEKSE MNSVNNSSLI PQNEKREKVN TSTMEKSRED GSVYPIASMN
IDLENRLEDL VSFGNSYLSE NNDNISQPFQ HDKDLGKCQE PFDVPDHVKD NATALWRRFE
LSTTKLSHEL TEQLRLVMEP TVASKLQGDY RTGKRINMKK VIPYIASDYS KDRIWLRRTR
PNKRDYQVVI AVDDSHSMSE NGCGDVAIEA LVTVCRAVSQ LEMGSLAVAS FGTKGNIKLL
HDFDRPFTGE SGVKMISNLT FKQENTIADE PVVDLLKYLT NKLDTAVAKA RLPSGHNPLQ
QLVLIIADGR FVEKKKLKQC VRDVSTGNRM VAFLLLDNSQ ESIMDLKEAS VEGGQTKIFK
YMDSFPFPYY IVLRNIEALP RTLANLLRQW MELMQHSTG
//
