ID A0A445GZ95_GLYSO Unreviewed; 1108 AA.
AC A0A445GZ95;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=Telomerase reverse transcriptase {ECO:0000256|ARBA:ARBA00016182, ECO:0000256|RuleBase:RU365061};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493, ECO:0000256|RuleBase:RU365061};
DE AltName: Full=Telomerase catalytic subunit {ECO:0000256|RuleBase:RU365061};
GN ORFNames=D0Y65_042226 {ECO:0000313|EMBL:RZB66562.1};
OS Glycine soja (Wild soybean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC Glycine subgen. Soja.
OX NCBI_TaxID=3848 {ECO:0000313|EMBL:RZB66562.1, ECO:0000313|Proteomes:UP000289340};
RN [1] {ECO:0000313|EMBL:RZB66562.1, ECO:0000313|Proteomes:UP000289340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. W05 {ECO:0000313|Proteomes:UP000289340};
RC TISSUE=Hypocotyl of etiolated seedlings {ECO:0000313|EMBL:RZB66562.1};
RA Xie M., Chung C.Y.L., Li M.-W., Wong F.-L., Chan T.-F., Lam H.-M.;
RT "A high-quality reference genome of wild soybean provides a powerful tool
RT to mine soybean genomes.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the
CC replication of chromosome termini in most eukaryotes. It elongates
CC telomeres. It is a reverse transcriptase that adds simple sequence
CC repeats to chromosome ends by copying a template sequence within the
CC RNA component of the enzyme. {ECO:0000256|RuleBase:RU365061}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557,
CC ECO:0000256|RuleBase:RU365061};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365061}.
CC Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
CC -!- SIMILARITY: Belongs to the reverse transcriptase family. Telomerase
CC subfamily. {ECO:0000256|ARBA:ARBA00008001,
CC ECO:0000256|RuleBase:RU365061}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RZB66562.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; QZWG01000015; RZB66562.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A445GZ95; -.
DR Proteomes; UP000289340; Chromosome 15.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003721; F:telomerase RNA reverse transcriptase activity; IEA:InterPro.
DR CDD; cd01648; TERT; 1.
DR Gene3D; 1.10.132.70; -; 1.
DR Gene3D; 1.10.357.90; -; 1.
DR Gene3D; 3.30.70.2630; -; 1.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR021891; Telomerase_RBD.
DR InterPro; IPR003545; Telomerase_RT.
DR InterPro; IPR049139; TERT_C.
DR PANTHER; PTHR12066; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR12066:SF0; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR Pfam; PF12009; Telomerase_RBD; 1.
DR Pfam; PF21399; TERT_C; 1.
DR SMART; SM00975; Telomerase_RBD; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU365061};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU365061};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU365061};
KW Reference proteome {ECO:0000313|Proteomes:UP000289340};
KW RNA-directed DNA polymerase {ECO:0000256|RuleBase:RU365061,
KW ECO:0000313|EMBL:RZB66562.1};
KW Telomere {ECO:0000256|ARBA:ARBA00022895, ECO:0000256|RuleBase:RU365061};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365061}.
FT DOMAIN 575..914
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 257..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 127458 MW; F83E0C05F9A5018E CRC64;
MTRKRRKPAV PGVLWRMFRG RARTLSDTII SLLPPPPPPP PLVCHCRGCG CLGCTVDAEK
FLLRPDDPSD YCKLLSKCFV VVSGNAPSPL PFFFPPSSRL SQHMIVGRTI EQMLLREQHS
NVLCSGYDQS KCSSPIVELL SCASWCLLLS RVGDYFMFYL LRNTSIFLPA PRGKHNQVAG
PPISDLCFEM LMGSSKFHHQ KYGEQKRERA DADDLPVKKQ KCYSSYSTTC PGGFSINLDF
TSESSMQVIR HHGTRDYDAS VSEVPKSTRT GTVTRKLESE GEQGLNCITP RLGKRSRPFK
WQRRSYKKQK QSSPEENSLN THCNVLPTNT DSMHAGSQSN TTGLSYHAKL QMPWQCSCCL
ILQSLPAVPR RTEIKRQSIF YNQEYSHEVF PKKHILYSLK PNLAYSKRLI DNIFGFSNAQ
PISCLHSNGT CLIDSGCLYH SLVKWFKHLI RRTRYCQHTK LLNKHCVPSL DLDKNTIGRS
SSRLKDNVST TNVHKKYEEF GIKYCADTMD TTDSQSETFK SYCSKSQVVS FIWAVSRSIL
PSELLGTPPT WRIMRRNISK FIHLRRFEKF PLKLCMHKLK ISSFPFLSNN FFLNSQSASV
LKYIEGKNKF FHQEFKNWND AVHGVKRKLL EKWIFWYFSF LVVPLVEANF YVTESEQGKQ
DIYYYRKSVW EKLAASTVSC FKDWRYSYLD DVAVHNILKG RPFGFSKLRL QPKENGVRMV
ANLEGSSRIP LLHSMGVRNC KTKGKERWKS VKKKALYADL VQHVKRNVLQ FDGKFYLQGV
GIPQGGVLSS LLCSMYYGHL ERHVIFPFLE KTLESGSCIE NNFGQTNCDD KVSSSCYLLM
RFIDDFLFIS TSKKQAASFF SRLERGFRGY NCYMNNKKFG ANFDVEHTSD SPLNRVYVGE
DGATSFLQWS GLLINCSTME IQADYTKYLG SHLSSTLTVC WQGKPGINLK EKLRLFLRPK
CHPIFCDSNI NSAAVVRLNI YQVCLLCAMK FHCYIRDLSI MCKLHKRFCS NIIQRSLRYM
YQMIKKQMHS ISLNSDIQPI LVLEKEEVEW LGFHAFVQVL KRKQSQHKEL LSILRSRLSS
HRISESVSPE LKYAINTKNS SLLWNIKY
//