ID A0A445I6D0_GLYSO Unreviewed; 474 AA.
AC A0A445I6D0;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform B {ECO:0000313|EMBL:RZB81447.1};
DE SubName: Full=Deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like isoform C {ECO:0000313|EMBL:RZB81448.1};
GN ORFNames=D0Y65_030946 {ECO:0000313|EMBL:RZB81448.1};
OS Glycine soja (Wild soybean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC Glycine subgen. Soja.
OX NCBI_TaxID=3848 {ECO:0000313|EMBL:RZB81448.1, ECO:0000313|Proteomes:UP000289340};
RN [1] {ECO:0000313|EMBL:RZB81448.1, ECO:0000313|Proteomes:UP000289340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. W05 {ECO:0000313|Proteomes:UP000289340};
RC TISSUE=Hypocotyl of etiolated seedlings {ECO:0000313|EMBL:RZB81448.1};
RA Xie M., Chung C.Y.L., Li M.-W., Wong F.-L., Chan T.-F., Lam H.-M.;
RT "A high-quality reference genome of wild soybean provides a powerful tool
RT to mine soybean genomes.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-
CC deoxyribonucleoside + H(+) + triphosphate; Xref=Rhea:RHEA:46148,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18036,
CC ChEBI:CHEBI:18274, ChEBI:CHEBI:61560;
CC Evidence={ECO:0000256|ARBA:ARBA00001432};
CC -!- SIMILARITY: Belongs to the SAMHD1 family.
CC {ECO:0000256|ARBA:ARBA00005776}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RZB81448.1}.
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DR EMBL; QZWG01000011; RZB81447.1; -; Genomic_DNA.
DR EMBL; QZWG01000011; RZB81448.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A445I6D0; -.
DR Proteomes; UP000289340; Chromosome 11.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 3.30.70.2760; -; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR045509; HD_assoc_2.
DR InterPro; IPR006674; HD_domain.
DR PANTHER; PTHR11373; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE; 1.
DR PANTHER; PTHR11373:SF4; DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF19276; HD_assoc_2; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:RZB81448.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000289340}.
FT DOMAIN 75..213
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
SQ SEQUENCE 474 AA; 54784 MW; 8F072F1504E532BE CRC64;
MGAYCNGNVS LSPSYDVASA EDPRFCKHVH DNVHGNIYLD SLSLKFIDTE QFQRLRELKQ
LGFTNMVYPG AVHSRFEHSL GVYWLASQCV EKLKTYQGLE LGIDRFDIQT VKLAGLLHDV
GHGPFSHLFE REFLPQVISG SDWSHEQMSV DMVDYIVDEH HIDVYPQMIR RVKEMILASS
EYAPSMSSSE KSFLYDIVAN GRNGIDVDKF DYLLRDCRAC GLGCNFEFQR LLETMRVLDD
EICYRAKDYL TIHKMFATRA DLYRTVYTHP KVKAIELMVV DALVHANSYL GISSNIHDPS
EYWKLDDTII KTIETTPNQE LKEARELILR IRRRNLYQFC NEYPVPKDML DNYKKVTAQD
IVCSQKSGGV TLKEEDVAVC NVKIDLTRGK HNPLESIHFF KDYESDEKFT IPDDRVSHLL
PTSYQDMIVK VYAKKPELVE AISEAFENFQ LKTYGIKTQA HSTPQKKRRY NSFI
//
