ID A0A445IQJ1_GLYSO Unreviewed; 927 AA.
AC A0A445IQJ1;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=aminodeoxychorismate synthase {ECO:0000256|ARBA:ARBA00013139};
DE EC=2.6.1.85 {ECO:0000256|ARBA:ARBA00013139};
DE AltName: Full=Para-aminobenzoate synthase {ECO:0000256|ARBA:ARBA00031329};
DE AltName: Full=p-aminobenzoic acid synthase {ECO:0000256|ARBA:ARBA00031904};
GN ORFNames=D0Y65_027702 {ECO:0000313|EMBL:RZB88351.1};
OS Glycine soja (Wild soybean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC Glycine subgen. Soja.
OX NCBI_TaxID=3848 {ECO:0000313|EMBL:RZB88351.1, ECO:0000313|Proteomes:UP000289340};
RN [1] {ECO:0000313|EMBL:RZB88351.1, ECO:0000313|Proteomes:UP000289340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. W05 {ECO:0000313|Proteomes:UP000289340};
RC TISSUE=Hypocotyl of etiolated seedlings {ECO:0000313|EMBL:RZB88351.1};
RA Xie M., Chung C.Y.L., Li M.-W., Wong F.-L., Chan T.-F., Lam H.-M.;
RT "A high-quality reference genome of wild soybean provides a powerful tool
RT to mine soybean genomes.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-
CC glutamate; Xref=Rhea:RHEA:11672, ChEBI:CHEBI:29748,
CC ChEBI:CHEBI:29985, ChEBI:CHEBI:58359, ChEBI:CHEBI:58406; EC=2.6.1.85;
CC Evidence={ECO:0000256|ARBA:ARBA00001000};
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-
CC aminobenzoate from chorismate: step 1/2.
CC {ECO:0000256|ARBA:ARBA00005009}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the anthranilate
CC synthase component I family. {ECO:0000256|ARBA:ARBA00005970}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RZB88351.1}.
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DR EMBL; QZWG01000010; RZB88351.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A445IQJ1; -.
DR OrthoDB; 201921at2759; -.
DR UniPathway; UPA00077; UER00149.
DR Proteomes; UP000289340; Chromosome 10.
DR GO; GO:0046820; F:4-amino-4-deoxychorismate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0046656; P:folic acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01743; GATase1_Anthranilate_Synthase; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005802; ADC_synth_comp_1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR006805; Anth_synth_I_N.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR017926; GATASE.
DR InterPro; IPR006221; TrpG/PapA_dom.
DR NCBIfam; TIGR00553; pabB; 1.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF18; AMINODEOXYCHORISMATE SYNTHASE; 1.
DR Pfam; PF04715; Anth_synt_I_N; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR Pfam; PF00117; GATase; 2.
DR PRINTS; PR00097; ANTSNTHASEII.
DR PRINTS; PR00099; CPSGATASE.
DR PRINTS; PR00096; GATASE.
DR SUPFAM; SSF56322; ADC synthase; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:RZB88351.1};
KW Folate biosynthesis {ECO:0000256|ARBA:ARBA00022909};
KW Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605};
KW Lyase {ECO:0000313|EMBL:RZB88351.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000289340};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:RZB88351.1}.
FT DOMAIN 97..257
FT /note="Glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF00117"
FT DOMAIN 303..341
FT /note="Glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF00117"
FT DOMAIN 461..603
FT /note="Anthranilate synthase component I N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04715"
FT DOMAIN 658..915
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT ACT_SITE 181
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 325
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 327
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 927 AA; 103992 MW; 36A37F3316DE240C CRC64;
MNSSLRLFSS ELTCPASEST QNANVNFLLS RPSLRVSCFV KKGGDARVRV SNRDGRKTKA
VVCCQLMHSH KEESDERKRR LQVVPVPVQK ADFVRTLLID NYDSYTYNIF QELSIINGVP
PVVIQNDDWT WEELCHYLYK ENAFDNIVIS PGPGSPACPE DIGICLQLLL KCWDIPILGV
CLGHQALGYV HGAQVVHASE PIHGRLSEVE HNGCQLFRDI PSGKNYGFKV VRYHSLVIDS
ESLPAELIPI AWTSSTSTLP FIGSKDFGKS NTHEAQPDQS ISIDPLLAKV GNGSSNHFDY
GKTRSARVLM GIRHSTRPHY GVQFHPESVA TCYGSQIFKN FREITDDYWL RFRSSFKETH
AYSDACMQVS SANRLYREVC RSISTENNAV DQLKQIVHAD RHLEYNKAEM KHLEMFNMVN
THHATTGYKC LKLKWRKFGH LAGQVGGAKG IFCGLFGLEA ENTFWLDSSS TEKGRARFSF
MGGKGGSLWK QLVFRLSHQS DGSSKGGGYL STEDSQGSAE TIFLEEGFLD FLNKELQSYR
YDKNEYEGLP FDFHGGYIGY IGYNLKVECG VKSNRHKSKT PDACFFFADN LVAIDHKNDD
VYILAIHEES SSITQWLNDT EEKLLSLNGS VRMALERQKS LPLTFSSCKV GFAAEKSKEQ
YIEDVKKCLN YIKDGESYEL CLTTQIRKSI EELNSLELYL HLRERNPAPY AAWLNFSKVD
LSICCSSPER FLQLDRKNIL EAKPIKGTIA RGATEEEDEQ LKFKLQFSEK DQAENLMIVD
LLRNDLGRVC DPGSVHVPRL MDVESYATVH TMVSTIRGKK RSDVSAVDCV KAAFPGGSMT
GAPKLRSMEL LDSIESCSRG IYSGCIGFFS YNQAFDLNIV IRTVIVHEGE ASIGAGGAIV
ALSNPEDEYE EMVLKTKAPT RAVMHFA
//
