ID A0A445LHD9_GLYSO Unreviewed; 530 AA.
AC A0A445LHD9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 08-NOV-2023, entry version 15.
DE RecName: Full=3-ketoacyl-CoA synthase {ECO:0000256|PIRNR:PIRNR036417};
DE EC=2.3.1.- {ECO:0000256|PIRNR:PIRNR036417};
GN ORFNames=D0Y65_008279 {ECO:0000313|EMBL:RZC22577.1};
OS Glycine soja (Wild soybean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC Glycine subgen. Soja.
OX NCBI_TaxID=3848 {ECO:0000313|EMBL:RZC22577.1, ECO:0000313|Proteomes:UP000289340};
RN [1] {ECO:0000313|EMBL:RZC22577.1, ECO:0000313|Proteomes:UP000289340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. W05 {ECO:0000313|Proteomes:UP000289340};
RC TISSUE=Hypocotyl of etiolated seedlings {ECO:0000313|EMBL:RZC22577.1};
RA Xie M., Chung C.Y.L., Li M.-W., Wong F.-L., Chan T.-F., Lam H.-M.;
RT "A high-quality reference genome of wild soybean provides a powerful tool
RT to mine soybean genomes.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a very-long-chain acyl-CoA + H(+) + malonyl-CoA = a very-long-
CC chain 3-oxoacyl-CoA + CO2 + CoA; Xref=Rhea:RHEA:32727,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57384, ChEBI:CHEBI:90725, ChEBI:CHEBI:90736;
CC EC=2.3.1.199; Evidence={ECO:0000256|ARBA:ARBA00001906};
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194, ECO:0000256|PIRNR:PIRNR036417}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531,
CC ECO:0000256|PIRNR:PIRNR036417}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RZC22577.1}.
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DR EMBL; QZWG01000003; RZC22577.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A445LHD9; -.
DR SMR; A0A445LHD9; -.
DR OrthoDB; 930987at2759; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000289340; Chromosome 3.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009922; F:fatty acid elongase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR012392; 3-ktacl-CoA_syn.
DR InterPro; IPR013747; ACP_syn_III_C.
DR InterPro; IPR013601; FAE1_typ3_polyketide_synth.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR31561; 3-KETOACYL-COA SYNTHASE; 1.
DR PANTHER; PTHR31561:SF73; 3-KETOACYL-COA SYNTHASE 1; 1.
DR Pfam; PF08541; ACP_syn_III_C; 1.
DR Pfam; PF08392; FAE1_CUT1_RppA; 1.
DR PIRSF; PIRSF036417; 3-ktacl-CoA_syn; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|PIRNR:PIRNR036417,
KW ECO:0000313|EMBL:RZC22577.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000289340};
KW Transferase {ECO:0000256|PIRNR:PIRNR036417, ECO:0000313|EMBL:RZC22577.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 113..399
FT /note="FAE"
FT /evidence="ECO:0000259|Pfam:PF08392"
FT DOMAIN 417..497
FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08541"
FT ACT_SITE 254
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 333
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 418
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 422
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 451
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
FT ACT_SITE 455
FT /evidence="ECO:0000256|PIRSR:PIRSR036417-1"
SQ SEQUENCE 530 AA; 58973 MW; 2B128B5DB8B6DF1E CRC64;
MGRNSIDMDR ERLTAEMDFK DSSSAVIRIR RRLPDFLQSV KLKYVKLGLG YGYSYSCKAA
SIVMLAITLP LVFSLTGGIK LSKLCSHNHQ LDAETVAAAS AALLSLAALY WWKRSPAVYL
VDFACYKPEK ERKISVEGFL KMTEESGGFE EESLQFQRKI STRAGLGDET YLPRGITSRP
PKLCMSEARL EAEAVMFGAL DALLAKTGVD PKDIDILVVN CSLFNPTPSL SAMIVNHYRL
RSNIKSYNLG GMGCSAGLIS VDLAKDLLKA NPNSYAVVVS TENITLNWYM GNDRSMLLCN
CIFRMGGAAV LLSNKPSDMA RSKYQLLHTV RTHKGADDKN YNCVYQKEDQ SGKIGVCLAR
ELMAVAGEAL KTNITTLGPL VLPYSEQVMF VVSLVRRKVL KMSGVKPYIP DFKLALEHFC
IHAGGRAVLD ELQKNLELSE WHMEPSRMTL HRFGNTSSSS LWYELAYTEA KGRVSKGDRV
WQIAFGSGFK CNSAVWKAVR DMPFLKDWRG NPWDDSINNY PVHLPSASSN
//
