ID A0A445M3Q9_GLYSO Unreviewed; 1204 AA.
AC A0A445M3Q9;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 08-NOV-2023, entry version 16.
DE SubName: Full=DNA mismatch repair protein MLH3 isoform B {ECO:0000313|EMBL:RZC30186.1};
GN ORFNames=D0Y65_001677 {ECO:0000313|EMBL:RZC30186.1};
OS Glycine soja (Wild soybean).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; indigoferoid/millettioid clade; Phaseoleae; Glycine;
OC Glycine subgen. Soja.
OX NCBI_TaxID=3848 {ECO:0000313|EMBL:RZC30186.1, ECO:0000313|Proteomes:UP000289340};
RN [1] {ECO:0000313|EMBL:RZC30186.1, ECO:0000313|Proteomes:UP000289340}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. W05 {ECO:0000313|Proteomes:UP000289340};
RC TISSUE=Hypocotyl of etiolated seedlings {ECO:0000313|EMBL:RZC30186.1};
RA Xie M., Chung C.Y.L., Li M.-W., Wong F.-L., Chan T.-F., Lam H.-M.;
RT "A high-quality reference genome of wild soybean provides a powerful tool
RT to mine soybean genomes.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RZC30186.1}.
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DR EMBL; QZWG01000001; RZC30186.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A445M3Q9; -.
DR Proteomes; UP000289340; Chromosome 1.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000289340}.
FT DOMAIN 214..349
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 966..1126
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 769..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 777..797
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1204 AA; 136719 MW; 876ECC8C5276456E CRC64;
MASIKPLPEA VRSSLRSGIF LFDFTRVVEE LVFNSLDARA TKVSVFVSTR SCYLKVVDDG
SGIPRDELEL VGERYATSKF LNLIDLNATS ENFGFRGEAL ASISEVSLLE IVTKTYGRPN
GYRKVLKGCK CLYLGIDDDR KEVGTTVVVR DLFYNQPVRR KYMQSSPNKV LQSIKNCIMR
LALVRPNISF KVVDIEREDE LFCTHSASSP LPLVTSGFGV EVASSLHNLE VENDIVKLSG
YISGPCNTVY TKALQYVYVN SQFVCKGPVH KLVSQLANRL EHLNSWNTDK EFRSKKRTRC
QPCPAYLLNL SCPRSLYDLA FEPSKTHVKF KDWTPILNFI EKAIKQFWEE NIACVDPSNE
ATYMVEDQQE KADVNIISAV SDMSKFRNQN RKDCLDLFFS TSDNLIEDDY HQSKMEDVDY
FGATMFKVQQ SKGDFLLQTG YSGNLLDGSY AKCNSTVMRK HNSLLMHDSN SLLEGDNFFD
GEIPAVESFN IDVPFDAPSS SHGRRFHKVE ADVINESFED DLLYNSCSGY GYDVKINGDL
QQPFLKRCSM LGSILHEKAL FVNDEHELQT DGFWSKQNTE EDYRSGKDLY VHRCPEVTKK
LKITKDSDFL VRPLSEENCL PPDSCYSALQ IGSSGSDDQL LNFEWHPVHQ NPSSQASALG
VCHTTDIEDE LGEISRYYKR IHHTKHFDDR EADCRFSYNM SRNANQHCCA SSFANIGFNF
DVAGDCGEIF NRLVDRPDFG DIHSSKRSDI LNEEPDWLLS KSCIKSCKRP NKNKGKRDRF
RNSTLEENLE RSRRSFSAPP FHRSKRRFFS LNHPSEMIAK RQIGRVSNPA FNHQEASNFK
YPQQSPVALH QSTEDFLLQE FKINVKQTTE VLGDMQDNDI ADIDEFESFN IQKSAPFGEL
ISRDVQDSID YGTKWRNCSP KITNDKLANI QSQNNILDIS SGFLHLAGDS LIPETISKKC
LEDAKVLHQV DKKFIPVVAG RTLAVIDQHA ADERIRLEEL RQKVLSGEEK AITYLDAEQE
LVLPEIGYQL LHSYSEQIKD WGWICNIHAQ NSESFRRSLD ILNRPQMAVT LIAVPCILGV
KLNDVDLLEF LQQLADTDGS STMPPSVLRV LNLKACRGAI MFGDSLLPSE CSLIVEELKH
TSLCFQCAHG RPTTVPLVNL EALHNQIAKL RLMNERSSDE WHGLHRHKVC IERAAQRLNF
ARGI
//
