ID A0A446BJH4_9PEZI Unreviewed; 834 AA.
AC A0A446BJH4;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 03-MAY-2023, entry version 11.
DE RecName: Full=Probable vacuolar protein sorting-associated protein 16 homolog {ECO:0000256|PIRNR:PIRNR007949};
GN ORFNames=TT172_LOCUS5035 {ECO:0000313|EMBL:SPQ22616.1};
OS Thermothielavioides terrestris.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Thermothielavioides.
OX NCBI_TaxID=2587410 {ECO:0000313|EMBL:SPQ22616.1, ECO:0000313|Proteomes:UP000289323};
RN [1] {ECO:0000313|EMBL:SPQ22616.1, ECO:0000313|Proteomes:UP000289323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Huttner S., Dainat J.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential for vacuolar protein sorting. Required for vacuole
CC biogenesis, stability and to maintain vacuole morphology.
CC {ECO:0000256|PIRNR:PIRNR007949}.
CC -!- SIMILARITY: Belongs to the VPS16 family.
CC {ECO:0000256|ARBA:ARBA00009250, ECO:0000256|PIRNR:PIRNR007949}.
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DR EMBL; OUUZ01000009; SPQ22616.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A446BJH4; -.
DR Proteomes; UP000289323; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0007033; P:vacuole organization; IEA:InterPro.
DR Gene3D; 1.10.150.780; Vps16, C-terminal region; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016534; VPS16.
DR InterPro; IPR006925; Vps16_C.
DR InterPro; IPR038132; Vps16_C_sf.
DR InterPro; IPR006926; Vps16_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12811; VACUOLAR PROTEIN SORTING VPS16; 1.
DR PANTHER; PTHR12811:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG; 1.
DR Pfam; PF04840; Vps16_C; 1.
DR Pfam; PF04841; Vps16_N; 1.
DR PIRSF; PIRSF007949; VPS16; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|PIRNR:PIRNR007949};
KW Transport {ECO:0000256|PIRNR:PIRNR007949}.
FT DOMAIN 6..411
FT /note="Vps16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04841"
FT DOMAIN 504..813
FT /note="Vps16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04840"
SQ SEQUENCE 834 AA; 93086 MW; 9FE12553498B167F CRC64;
MDVAHPTAGW EQLGDRFYRK TQLYAQVFDQ DLDLDNYLVA GAPYGGAIAL YRDEDKLIAF
QATHPSKPSI DIYSCAGKLI RRINWDQGSI KGLGWSEDEK LLVVTADGTV RCYYDLQGEF
TQFSLGNGAD EAGVQSCRFY AHGLVALLKN NALVSVSSYD EPRPKLLASP PEGQVHSWNI
IPPAYTLSRS VEVLLSIGQT IYMCDASECE DRFLDIGPFS HIAVSPNGRF CALYTATGQA
HVITSDFQTR LSEHNSRSKI SPKYFEWCGN DAVVIAWEDE VHLVGPSGSL AKFFYDSGRV
HIVPDYDGVR IVANETCDFL QKVPDVTEEV FRLGSGSPAS ILLDAVEQLE MQSPKADDNI
QLIRPQLAEA VDTCVSAAGQ EFSVHWQKQL LKAASFGKSV LDIYNSDDFV DMCETLRVLN
AVRFFEIGLP LSYEQYQRLS PSGLISRLLN RHEYLLALRI AGYLRLPTDK IYVHWASAKV
RLGAEDDDAI CRKIVEKLSG KPGISFDVIA RAAYDEGRGR LATELLNHEP RAGRQVPLLL
SMEEDELALD KAIESGDTDL IYFVLHQLKR KLPLAGFFRV INSRPTATAL VEASARQGDA
DGREDTALLK DLYYQDDRRL EGATVFVREA LRQPESRTAS DKLSLAAKLL SDNAKEHAFE
IGALKEATTL LRMQEAFDRD LTDSFTGLSV NQTMFKLIKL GYHGRAKKIQ SEFKVPEKVA
WWIRLQALVA KRDWNELEEI SRQRKSPIGW EPFFNQILQA GNPRLAASFI PKCTGLAPGQ
TVTMYEKCGM RVKAAEEAVK IKDAEAWSRL LEAAGRGTAE GREIERLGLA VFKR
//
