ID   A0A448HYP5_MYCCI        Unreviewed;       958 AA.
AC   A0A448HYP5;
DT   08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT   08-MAY-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Probable membrane protein, MmpL {ECO:0000313|EMBL:VEG45234.1};
GN   Name=mmpL8_2 {ECO:0000313|EMBL:VEG45234.1};
GN   ORFNames=NCTC10485_00484 {ECO:0000313|EMBL:VEG45234.1};
OS   Mycolicibacterium chitae (Mycobacterium chitae).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=1792 {ECO:0000313|EMBL:VEG45234.1, ECO:0000313|Proteomes:UP000282551};
RN   [1] {ECO:0000313|EMBL:VEG45234.1, ECO:0000313|Proteomes:UP000282551}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC10485 {ECO:0000313|EMBL:VEG45234.1,
RC   ECO:0000313|Proteomes:UP000282551};
RG   Pathogen Informatics;
RL   Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR   EMBL; LR134355; VEG45234.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A448HYP5; -.
DR   OrthoDB; 4758927at2; -.
DR   Proteomes; UP000282551; Chromosome 1.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   NCBIfam; TIGR00833; actII; 1.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000282551};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        193..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        245..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        298..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        332..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        377..399
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        764..782
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        789..814
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        820..841
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        868..886
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        898..926
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          53..381
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          601..937
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   958 AA;  104340 MW;  D1FA6102DF82B96D CRC64;
     MRDRSMNSRR SVVARTVHRL AVPIIVGWLL IVGLVTFAVP SLEQVGREYS VSLVPTDAPS
     LKAMQRMGDR FQESSSDSVA MIVVEGQQPL ADEAHRYYDE LVRQLRADAA HVQHVQDFWG
     DPLTASGVES ADGMAVYVQL NLAGNQGEAL ANESVQAVRD IVEAMDPPPG VAAYVAGPAP
     LVTDMNHAGD QSIIRITLVT LVVILTMLLL FYRSITTAVL ILVMVGIQVQ VARGLVAVLG
     DHTVIGLSTF AVNLLVSLAI AVGTDYGIFF TGRYQEARQA GEDRESAFYT TYASVAKVVL
     ASGLTIAGAI FCLSFARLPY FQTMGVPCAV GMLAAVGVAL TLIPAVIAVG GRFGLLDPKR
     KVRVRRWRRV GTATVRWPVP VLTTACVVAL IGLLALPAYT TSYNDRLYVP PDIPANIGQA
     AAERHFPSAR LMPDILLIDA DHDMRNPADF LTLNKLAKSV FGVPGVARVQ SVTRPEGAPI
     ARTSIPFQLS LQSASQVHLL PFQRDRVGDL LTQADDLDVM IGIMARMYGV MQKFAATTEA
     MVKDTHELEY FTNELRDNIA NFDDFFRPIR NYLYWEPHCF NIPLCWSTRS LFDSIDGIDQ
     VSAKMRELVA DFDRLNKLMP GLLDELPGVI ASMQSMRTMV LTMHSTMSGM YELMDDVSAD
     STAMGKVFDA AQNDDSFYLP PEIFDNKDFQ RAMSLFFSPD GKTMRMFIEH RGDPATPEGI
     ARVEAISDAA EEALKVTPLE NAQIYLAGTA STFKDMRDGS NYDLLIAGVA ALGLILSIML
     IITRSLIAAL VIVGTVAISL GAAFGLSVLV WQHILGIELH WLVLAMSVIV LLAVGSDYNL
     LLVSRMREEM GAGINTGIIR AMGGSGKVVT AAGLVFAFTM MSMVVSDLRI IGQVGSTIGI
     GLLLDTLVVR ALMTPSIAAL LGRWFWWPQR VRQRPASSML RATAPRSVTR ALLLREEP
//