ID A0A448KA93_9ACTO Unreviewed; 1087 AA.
AC A0A448KA93;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN Name=dnaX_1 {ECO:0000313|EMBL:VEG73846.1};
GN ORFNames=NCTC11923_00458 {ECO:0000313|EMBL:VEG73846.1};
OS Actinomyces slackii.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=52774 {ECO:0000313|EMBL:VEG73846.1, ECO:0000313|Proteomes:UP000276899};
RN [1] {ECO:0000313|EMBL:VEG73846.1, ECO:0000313|Proteomes:UP000276899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC11923 {ECO:0000313|EMBL:VEG73846.1,
RC ECO:0000313|Proteomes:UP000276899};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DnaX/STICHEL family.
CC {ECO:0000256|ARBA:ARBA00006360}.
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DR EMBL; LR134363; VEG73846.1; -; Genomic_DNA.
DR RefSeq; WP_034514961.1; NZ_LR134363.1.
DR AlphaFoldDB; A0A448KA93; -.
DR STRING; 1278298.GCA_000428685_02133; -.
DR KEGG; asla:NCTC11923_00458; -.
DR Proteomes; UP000276899; Chromosome 1.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd18137; HLD_clamp_pol_III_gamma_tau; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR022754; DNA_pol_III_gamma-3.
DR InterPro; IPR012763; DNA_pol_III_sug/sutau_N.
DR InterPro; IPR045085; HLD_clamp_pol_III_gamma_tau.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02397; dnaX_nterm; 1.
DR PANTHER; PTHR11669:SF0; PROTEIN STICHEL-LIKE 2; 1.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR Pfam; PF13177; DNA_pol3_delta2; 1.
DR Pfam; PF12169; DNA_pol3_gamma3; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000313|EMBL:VEG73846.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000276899};
KW Transferase {ECO:0000313|EMBL:VEG73846.1}.
FT DOMAIN 36..180
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 372..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1007
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1059
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1087 AA; 108657 MW; FAC53376DF6C3DD3 CRC64;
MTTALYRRYR PDTFQDVIGQ EHVTAPLMAA LRAERVTHAY LFSGPRGCGK TTSARILARC
LNCAQAPTDT PCGQCPSCRN LATGGPGSLD VVEIDAASHN GVDDARDLRE RAAFAPARDR
YKIFILDEAH MVTAQGFNAL LKLVEEPPAH VKFIFATTEP EKVIGTIRSR THHYPFRLVP
PDTLEGYLGH LCGAEGVSAG PGVFPLVVRA GGGSVRDTLS VMDQLIGGAV DGAVDYQRAV
ALLGYTDTTM LDQCVDAIAA GDGAGVFRVV DRVVTSGHDP RRFVEDLLQR LRDLLVIALA
GSQAGPALGS LPDDELTRMD LQARTMGAAV LSRAADTTAQ ALTAMVGATS PRLQLELLVA
RLVIPAQPRG EAQAPAAPVG SAGSAGPAQQ GGQVAPAASA GAGSGRAVAG TTAPASRPGE
TPAGPGGASG SDGPAAGAGS PVVVDWEGTG ASAPASPSPE PTQARAAAQA PQAAPQAVSA
PPAVEDSGAA DGERPQPGVP SSPPAAAQGP GAAEAEMIRT RWEEVLEAAK RSRRATWALV
GPNSRPGTLT AGVFTLLFNA PGLVGAFENG GHGPIFSAAI HQALGLRVEV HAILAGPDGP
GGPGGPGGGA PDPSVPSGPG GQADWAAPVA PASAGDVGGW ERSASPGGGA LGPQALDQGS
ASGVEPDPRA SAAALGPEPE EEPGEPTAAE EPEPVWDEAV PPEPLADVEV PASEPANEPA
NEPANELANQ SAYEEAESWT PGPGTTVPWA GESAIEQDWA VGPAAGRGMP QAQAAPGSEP
SEEIGAEPQG QSDRPEPATA TPVADDAAPG DQAADISVPP VEDPAPADDG WGPVAVPGGQ
ATPDAAGSVE ADGGSGPASV DDDGWGPVAV PGGQATPDAA ESVEADGGSG PALADDDGWG
PVAVPGGQAS PAAVEPAEAP EDSGAGERDG AQVPAASPEP EAPLATVHRL RALPPMPEPQ
PQQAAPQRPG LTPVSWDGPA FSDGVPLPEE PGDPDGPAGP EPASPGIAAP SPDAATWTPT
GVPGSKLAAA MAAARAAAEA TEFSLEEDTP SEDDEDAEDA GVVGLEVVKR ILGATVIEEV
TVTQEGH
//