ID A0A448KCT8_9ACTO Unreviewed; 404 AA.
AC A0A448KCT8;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Cysteine desulfurase {ECO:0000313|EMBL:VEG74737.1};
DE EC=2.8.1.7 {ECO:0000313|EMBL:VEG74737.1};
GN Name=nifS {ECO:0000313|EMBL:VEG74737.1};
GN ORFNames=NCTC11923_01375 {ECO:0000313|EMBL:VEG74737.1};
OS Actinomyces slackii.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=52774 {ECO:0000313|EMBL:VEG74737.1, ECO:0000313|Proteomes:UP000276899};
RN [1] {ECO:0000313|EMBL:VEG74737.1, ECO:0000313|Proteomes:UP000276899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC11923 {ECO:0000313|EMBL:VEG74737.1,
RC ECO:0000313|Proteomes:UP000276899};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU004504};
CC -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC aminotransferase family. NifS/IscS subfamily.
CC {ECO:0000256|ARBA:ARBA00006490}.
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DR EMBL; LR134363; VEG74737.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A448KCT8; -.
DR STRING; 1278298.GCA_000428685_02534; -.
DR KEGG; asla:NCTC11923_01375; -.
DR Proteomes; UP000276899; Chromosome 1.
DR GO; GO:0031071; F:cysteine desulfurase activity; IEA:UniProtKB-EC.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.260.50; -; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000192; Aminotrans_V_dom.
DR InterPro; IPR020578; Aminotrans_V_PyrdxlP_BS.
DR InterPro; IPR016454; Cysteine_dSase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11601:SF34; CYSTEINE DESULFURASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11601; CYSTEINE DESULFURYLASE FAMILY MEMBER; 1.
DR Pfam; PF00266; Aminotran_5; 1.
DR PIRSF; PIRSF005572; NifS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00595; AA_TRANSFER_CLASS_5; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000276899};
KW Transferase {ECO:0000313|EMBL:VEG74737.1}.
FT DOMAIN 7..385
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
SQ SEQUENCE 404 AA; 40563 MW; 2A9785F8E49913FD CRC64;
MPIPERVYLD HAASSPVRPE VAAQVAEDLA GGLGAWANPS AQHASGRRAG ALLSQARARL
AAALGVDPHE VLFTSGGTEA DALVVAGRAR AVPGGRVVVS PIEHPAVADS AAAAAAHLGA
EVITLAVDSA GRVELESVAQ AVAASPGRAG ASLVSVMAAN NETGVVEDVA GIVERVRMAS
GAGPGQEGHV PVHSDAVAAV GRAPVDFHGW GLDAMSLSGH KLGGPVGVGA LVLRRETLLV
PPTGGGGQER GVRSGTQDVV AARALALAVE LAVAEQEAEA ARLGGLRRRL LEGACAVEGA
HATLPDDAVC LPSTAHLWFE GVDAEALLMA LDLAGVDASA GSACHAGVAR PSHVALAMGL
DEEAARATLR CSLGPTTTPQ DVERFLRVLP EAVKAARRAR ASRG
//
