ID A0A448MW86_9ACTN Unreviewed; 453 AA.
AC A0A448MW86;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=H(+)/Cl(-) exchange transporter ClcA {ECO:0000313|EMBL:VEH69384.1};
GN Name=clcA {ECO:0000313|EMBL:VEH69384.1};
GN ORFNames=NCTC12967_00651 {ECO:0000313|EMBL:VEH69384.1};
OS Arachnia propionica.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Arachnia.
OX NCBI_TaxID=1750 {ECO:0000313|EMBL:VEH69384.1, ECO:0000313|Proteomes:UP000273044};
RN [1] {ECO:0000313|EMBL:VEH69384.1, ECO:0000313|Proteomes:UP000273044}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12967 {ECO:0000313|EMBL:VEH69384.1,
RC ECO:0000313|Proteomes:UP000273044};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LR134406; VEH69384.1; -; Genomic_DNA.
DR RefSeq; WP_061788381.1; NZ_LR134406.1.
DR AlphaFoldDB; A0A448MW86; -.
DR GeneID; 64406137; -.
DR Proteomes; UP000273044; Chromosome 1.
DR GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd01033; ClC_like; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000273044};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 72..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..396
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 425..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 453 AA; 46980 MW; 682C8BAE83B5115E CRC64;
MSSDPSLQHN TTTSHTTAGA SGLRRFAAAV VLAGITAGVT GWACAHLLHT VEHFVWSISE
GHLVTALETV PWWRRFLTLA AAGVIGAVSW VLLHRTGPGP VSTEQAVAGR RMPVLRTIWH
AATQIIIIAM GASLGREVAP REAGAALSGW ISDRFGLNEE DRRILVACGA GAGLAAVYGI
PLSGIFFALE ALLATFSKRS LASALAVSGI AVFVSTGWAR PEVYYRMPEL VSSPALVAWA
VLCGPAIGLA GALFGEAVKR AEQKRPTTTR LLWVMPLGFA VVGAVSIWVP WVLGNGHPVT
QTVTNQVAEV GPQALGLITL LLLAKAVTTL ITVRAGAWGG TLNPGIALGA ALGGLTGLVW
SLIWPGSNLV ACVFIGAAAF LGASIKAPLT GFALVLELTH SGATVLVPTA LAIAGATAAA
SWWRNRGKKH DENNDDEETG PVALTTGPVE KVN
//
