ID A0A448MX44_9ACTN Unreviewed; 3740 AA.
AC A0A448MX44;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Polyketide synthase PksL {ECO:0000313|EMBL:VEH69703.1};
GN Name=pksL_2 {ECO:0000313|EMBL:VEH69703.1};
GN ORFNames=NCTC12967_00979 {ECO:0000313|EMBL:VEH69703.1};
OS Arachnia propionica.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Propionibacteriaceae; Arachnia.
OX NCBI_TaxID=1750 {ECO:0000313|EMBL:VEH69703.1, ECO:0000313|Proteomes:UP000273044};
RN [1] {ECO:0000313|EMBL:VEH69703.1, ECO:0000313|Proteomes:UP000273044}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12967 {ECO:0000313|EMBL:VEH69703.1,
RC ECO:0000313|Proteomes:UP000273044};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; LR134406; VEH69703.1; -; Genomic_DNA.
DR Proteomes; UP000273044; Chromosome 1.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08953; KR_2_SDR_x; 2.
DR CDD; cd00833; PKS; 3.
DR Gene3D; 1.10.1240.100; -; 2.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 3.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 3.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF21089; PKS_DH_N; 2.
DR Pfam; PF00550; PP-binding; 2.
DR Pfam; PF14765; PS-DH; 2.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000273044};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 45..460
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1310..1394
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1417..1839
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2899..3327
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 547..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3740 AA; 400205 MW; C6CE34E0EC926CFA CRC64;
MMTKTHEILR ALKEKRIDPY QAREALTALR TSAVETTSTA DTPRPEPIAV IGMSGRYAAA
ADLSSLWDLL VDGQDGVRDI PSDRWAPEPG DDIQCARMGY LDEIDRFDPY FFEISPSEAE
MMSPAHRIFL EEGYRAFEDA GIPRQELRGT KCGVYLGLST VEYQMMAQLA GAASSSVTSV
SNAIAGGRLP YFLDLRGPAV TLDTACSSSL VSIHLAAQAL RSGEIDLALA GGSATYLSRE
SYKKMHDAGM LSPSGRCAAF SEDADGFVPG EGAGAVVLKR LSDAERDGDH IWGLIIASGT
NQDGHTNGIT APNLGAQQEL IQEVHRRFDV DPDSISYAEL HGTGTKLGDP IELEALSAAF
RARTARTQFC TIGSVKSNLG HVSESAGVAS LQKVLLCMEH GQLVPTLHVG QPNPHFDFDT
SPFVIGTTTQ RWDVAAGQPR RACISSFGFS GTNAHVVVEE YQAPSRAAVV ATPEVLVLSA
PSLERARVMA GRLDEFLERH PDTRLEDVAF TLQTGRTPAR ERIAIVVDNL LDARRLLRAV
ADGEETPDVE FGRARRDNSA PTPGADPHEI ARAWVLGADV HWETLHTGSE PRRISLPTYP
FEKHRCWFAP SPTGSAEAVA RTVVVSGRET EVVQHTVKGV PTLPAAAIIE IIREASCVAQ
ERPVTELRDV TLRSPIFCSD GVTLEVAHDP QGHFELRPCG ALAPSCSGET GYGTTTPSSI
DLRAVSARCN QRVVLRWDEP GCAFGVGYGP AFRLLRELHA GTNEAIAQLA DGPRGEGERA
LAATILDSAW QAVGPLMAPD EVPAVPFHIE RIAFPGSLTD AEIVHVTRHR HGGFDVRVAD
RDGNVLVDCH GLTLAPLASP ANQSLTLLAP QWVESPAPKE ATAATPVLLV ADAEDLKNTE
EITRVRGTDT AEIVRALEQR PHPVVVVATR APAGDTAQAV RERVGAIREV TAALATARPR
KRQFLIHLHE GAHPADAAVS GYLTALEAED PRFQTRSIEV ETLPAGEDLL ALVAEETATT
GSRVRRTGST RQKRGFVELP VATDNAVFAD GIFLVTGAPG GLATRAAEHI QARGGHVVLS
GRRELDPIAS RKLRPLLDAG AVYLPADLGD AAAVSQMVDA ARSVLGRLDG VLHVAGRTRD
ALALHLTSND VEEVLAAKVT GTLALDAATA ADDLRCFVCF SSVSAELGTV GQTAYCAANA
FLDAFSTGRE AARSRGERRG VTVSIGWPYL LGGGMRIDDE TASRMREGWG LEPLDVTTMC
RALEAAVASG RSHVLPLAGD RDRIQRTFDL VPVTMPPMAL PVAPAEKNDE LRRATETWLV
SVVAETLHAD PAKVLAAESF ASLGVDSILM LQLVRAFEKE LGQLPKTLFF EFEDLDALTG
YFVAEHGAAL QALLGVVEPE PAPEPITVVE THETSCDEPI AIIGLSGRYP EAPDLDSFWR
NLRVGRDSVR EVPADRWDHS VWFDPEPGTP GKAYARWGGF LDGIQDFDPL FFGITPRDAA
VLDPQVRLFL EESWRAFEDA GLTRDALRGQ RVGVFAAAMY GMYELLQTEN DGVDVPVSSS
LSAIANRVSY FMNFTGPSLT VDSMCSSSLS ALHLGCQSIR QGESDIVLVG GVNLTVHPNK
LVLLSQGRFA ARDGRCRAFG ADGSGYVPGE GVGALVLKPL GRAIADGDPV RAVIRASVVN
SGGHTSGFTV PNPVAQAALV REGLDRAGVR ADSIGYVEAH GTGTQLGDPI EVEALTKAFR
NDTQERGFCS LGSVKTNIGH CEAAAGVAAL TKVLLQLQHR ELVPSLHADV PNPNIDFASS
PFVVQRALEP WPAGPAGVRR AAVSAFGAGG ANAHVIVEEF SSDEAYSPVE ERLFVFSARD
GGALNNVLGR FADWLERGLR ADSIITRLSE LTGVDAELIQ PGTPISELGL ASFEAQRLVL
EFAPSGTLPP LDGSSLTVAD LTASVADAMD ATPNLAAVAH TLQSGREVMP YRLAVVATRG
DELLRTLRAH LAGQSSDAIC GTAPSNRREL AAALEAVGGT QAMEALALER DLAALGRAWV
SGAAVPWELL YPGGLPRRVA LPTYPFARER CWAVRVPTPT HGAPRPLLGE RSETPGGCEY
RCRLSAEEFF LADHVIDGAS VLPAAVHLEL MRSALADSGV AGDLSDVILL APVRVTSESV
TLTVTVVQER PGTTEIEVLT MGADGERQVH ARASAVSTHD DRPIESLEVI RSRCHSGQLP
GEDCYRSFTD LGLNYGPRHR VLDHLALGEG EVLARIILPD TLRHGLERFG FHPALLDGAL
QAMLGLGSPN SSGAAELPFA LGSVQLLAPM AEGMWAHLRR SSSSTGLSKV DITLYDDAGI
PCVLLTDVAF RAVAGPEVPQ PSGLVFETCW KSAFAANGPA IPLDRWHIVG LNLDRELVDR
LSELPDLKVT ALTTTCETEA ERYTEHAVAL IGVLKRELSI PAGTRLVQLM LRGTEDTPMT
GLLGMLRSFR LEEPSALIQV LIVDESMSAD QAARAVVDER RCPEDDCVWL GGTRRALTWR
ELKLPASAAI RWHDNGTWLI TGGAGGLGRL VALDLARHTA NARLVLIGRS EPSESTAALV
ASLRAAGADA SYHRADVTSV TEMRDLVAQL GTVSGVVHCA GTVRDCLILG KTDEGVAAVL
RPKTTGIEVL DEVTRREPIR DFIVFSSLAG AIGNFGQADY AAGNAYCDRF AQRRRVAVAR
GERSGRTQSI GWALWEGGGM GHGTVSAEGL AQVGLSLLDD QLGLELLHRL ATVDSGHVVV
LTGITERLRA YVAGQSRNAL PSLPDDSSVL SDRLLGELCD LVSDRTGIDR ERLDARAPLD
ALGIDSIIIM DLTAQLEKKL GPLPRTVFFD NGSLAELADS LVADHPAECV AWLGTDGVPL
AAARQSVELP VAEPARETSP DIAIIGVAGR YPKSPTLEAL WENLQEGRDC VTSVPSDRWD
HDQFYDTSGE SGTTNAKWGG FIDNHASFDS LFFGISPSEA EVMDPQERVF LECVHHAIED
AGYTPETLSP QDEDGLPGRV GVFVGAMYLE YQLYGAQAQT RGDIYTTNGS AACISNRVSY
TFGFHGPSLT LDTMCSSSLV AIHLAVQSLR SGDADVAVAG GVNLSLHPNK FITLGMNHFA
SPTGRCHSFG ADADGYVPSE GVGALILKPL DAALRDGDHI HAVIKGTAVN SDGRTNGFTA
PSSIAQTAVI RKALRQAAVH PRDISYVEAH GTGTRLGDPI EVTALTRAFE DAPTDGSCFL
GSVKSNLGHC ESAAGMAGVA KVLLQLKHKQ LVPSIHCERL SPEIDFTDSP FTVSRRLRDW
TPRNGRRLAG VSAFGAGGTN AHVVIAEAPG LPEVQRIDDG EVLIVLSAMT TEALERQLGQ
LAEWIRRETP DAAVLADVAY TLQIGRRAHE ERFAAVAKDA ADLLRRLENP TAGQRGSVGE
SAPPAREAEV AAAIRSRDLA ALARLWVLGA QVPWRELHRD GRRRVSLPGY PFEVRHHWRP
TADLVAPSHG RPTGPDPVLR NESSLFEQRY VTNLPAIQSL VRPSDLAAMW ALPLVLACRA
GEAGLERSHA RLTDIAWLQS PLPDTEVITS LWPDDDSVLI QVGGSSKEVG FEARIAMDSG
VPSAEPPMEL QSVKERCSAV LPGTETGSSR VREVWLGMDE AICVLSGRSD VDEESRFLNL
LSGLMEAMEL WLTRTSGMCE GWCPESADEI ALFQSPVGDC LAHLKRRGAC IDIDVTDLSG
QLVARFNNIR VHEEALGVSA
//
