ID A0A448PF06_9ACTO Unreviewed; 539 AA.
AC A0A448PF06;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE SubName: Full=Multiple resistance and pH homeostasis protein D {ECO:0000313|EMBL:VEI13531.1};
GN Name=mrpD {ECO:0000313|EMBL:VEI13531.1};
GN ORFNames=NCTC13354_01247 {ECO:0000313|EMBL:VEI13531.1};
OS Trueperella bialowiezensis.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Trueperella.
OX NCBI_TaxID=312285 {ECO:0000313|EMBL:VEI13531.1, ECO:0000313|Proteomes:UP000269542};
RN [1] {ECO:0000313|EMBL:VEI13531.1, ECO:0000313|Proteomes:UP000269542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC13354 {ECO:0000313|EMBL:VEI13531.1,
RC ECO:0000313|Proteomes:UP000269542};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU000320}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU000320}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D
CC family. {ECO:0000256|ARBA:ARBA00005346}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LR134476; VEI13531.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A448PF06; -.
DR KEGG; tbw:NCTC13354_01247; -.
DR OrthoDB; 9768329at2; -.
DR Proteomes; UP000269542; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR PANTHER; PTHR42703:SF1; NA(+)_H(+) ANTIPORTER SUBUNIT D1; 1.
DR PANTHER; PTHR42703; NADH DEHYDROGENASE; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000269542};
KW Transmembrane {ECO:0000256|RuleBase:RU000320, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..99
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..294
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..470
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 131..421
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
FT REGION 499..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 539 AA; 56686 MW; 51D6C891254FE005 CRC64;
MTWTFLAALP VALPILGAGL SLAFASVRRM QGWLSAIVLG AVWVVAVVLL QMARSGPVVL
DVASWAAPVG ISLVVDRLSA IMLLTSVTVT LMVLLYSLAQ GVADGDDAAP IAVYHPAFLL
LSAGVSNAFL SGDLFNIYVG FEILLVASFV LITLGGTRDR IRSGTVYIVV SLISSVVFLI
GIGLAYAAAG TVNLAQLALR LPEIDPNVRL TIQMMLLVGF GIKAAVFPLS AWLPDSYPTA
PAPVTAVFAG LLTKVGVYTI IRTQTLLFPN NRLSIMLGLI AVATMIMGIL GAVAQQDIKR
LLSFTLVSHI GYMIWGISIA SEAGLGATIY YAVHHITVQT ALFLVVGLIE RRGGTTSLVR
LGSLAKLAPL IAILYLVPAL NLAGIPPGSG FFGKVGLIQA SINRLMWIDW LLIGAGIISS
LLTLYAVARA WNMAFWQTAP EPLPAKPIPW GMTASAGALV VVSLFISFWA GPINEYTKNA
AFELKARSPY IVAVLPEDGR GTGVSPLVPA DDLPSPEPTE APDWAPTPEK GGIGGSDNG
//
