ID A0A448YJR3_BRENA Unreviewed; 648 AA.
AC A0A448YJR3;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=DNA polymerase alpha subunit B {ECO:0000256|ARBA:ARBA00018596, ECO:0000256|PIRNR:PIRNR018300};
GN ORFNames=BRENAR_LOCUS1882 {ECO:0000313|EMBL:VEU21147.1};
OS Brettanomyces naardenensis (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Brettanomyces.
OX NCBI_TaxID=13370 {ECO:0000313|EMBL:VEU21147.1, ECO:0000313|Proteomes:UP000290900};
RN [1] {ECO:0000313|EMBL:VEU21147.1, ECO:0000313|Proteomes:UP000290900}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Tiukova I., Dainat J.;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also
CC known as the alpha DNA polymerase-primase complex) which plays an
CC essential role in the initiation of DNA synthesis.
CC {ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR018300}.
CC -!- SIMILARITY: Belongs to the DNA polymerase alpha subunit B family.
CC {ECO:0000256|ARBA:ARBA00007299, ECO:0000256|PIRNR:PIRNR018300}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CAACVR010000010; VEU21147.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A448YJR3; -.
DR STRING; 13370.A0A448YJR3; -.
DR InParanoid; A0A448YJR3; -.
DR Proteomes; UP000290900; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.60; -; 2.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR016722; DNA_pol_alpha_bsu.
DR InterPro; IPR013627; Pol_alpha_B_N.
DR PANTHER; PTHR23061; DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT; 1.
DR PANTHER; PTHR23061:SF12; DNA POLYMERASE ALPHA SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF08418; Pol_alpha_B_N; 1.
DR PIRSF; PIRSF018300; DNA_pol_alph_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR018300}; Nucleus {ECO:0000256|PIRNR:PIRNR018300};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000290900}.
FT DOMAIN 20..249
FT /note="DNA polymerase alpha subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08418"
FT DOMAIN 356..590
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
FT REGION 99..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 648 AA; 72880 MW; 946F47354CB79C94 CRC64;
MSVSIGAQIV EKFGPKADQP DILKKCEDLM ELFGLTAEEL FLKWETYVVT SSTIDDDMPL
TANNLSRLQE YIQKKIVKDN QKTPSTNHVK RPVIRATPNV SMTNVLPSTP MSLKKRRKLE
TPYSSDTSHL RGSDDSSFIT ARSSSPIRSS DLESTPSGHG KSTQESGSIL ETLNRDVIEL
TDVKTEADTA TKLRLVANFD PSKYKFRTMN QKLLEVADYL DDQIDTVAKI VLDHYHFDQS
EFGNPNLQSQ TGILTVGRIV PDSPLTEFDA DLNSNSLFLE TSRSGGIGQR ICLDVKDLDD
YSFFPGQIVC LRGINQTGDV FKVSHQYELP YLGAPVSTLD DLKAYQEQLS GENMKVVVTA
GPYSPSRELN FDLLSKFVDR MNEEVHPNAI IMFGPFLDIN HKQIRDGTLS FADLEREPKT
LDEVFKMVIA PILRRLNCRQ VIIIPSTKDA TTDHAAYPQE MFDRKGLGLS KNFKCFPNPA
TFSLNEVLIG CSNNDIFRDL KDVNSGRYVG ESRFNRVSEH VLEQRRFYPS FPGGIKRQRG
SLLVAEDRQN QDELFLSGAD LHVSYMGLTE FPDSLPDVLV IPSELKYFAK VVKNVLVINP
GSFVKMNSNG TYALMNARPP VVEDLQKIGE DLYLNDIWKR ARVDIVRS
//
