ID A0A448YK25_BRENA Unreviewed; 240 AA.
AC A0A448YK25;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 4 {ECO:0000256|ARBA:ARBA00020629, ECO:0000256|RuleBase:RU364141};
DE AltName: Full=Mediator complex subunit 4 {ECO:0000256|ARBA:ARBA00031257, ECO:0000256|RuleBase:RU364141};
GN Name=MED4 {ECO:0000256|RuleBase:RU364141};
GN ORFNames=BRENAR_LOCUS1938 {ECO:0000313|EMBL:VEU21203.1};
OS Brettanomyces naardenensis (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Brettanomyces.
OX NCBI_TaxID=13370 {ECO:0000313|EMBL:VEU21203.1, ECO:0000313|Proteomes:UP000290900};
RN [1] {ECO:0000313|EMBL:VEU21203.1, ECO:0000313|Proteomes:UP000290900}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Tiukova I., Dainat J.;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364141}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364141}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364141}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 4 family.
CC {ECO:0000256|ARBA:ARBA00009626, ECO:0000256|RuleBase:RU364141}.
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DR EMBL; CAACVR010000011; VEU21203.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A448YK25; -.
DR InParanoid; A0A448YK25; -.
DR Proteomes; UP000290900; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR019258; Mediator_Med4.
DR Pfam; PF10018; Med4; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364141};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364141};
KW Reference proteome {ECO:0000313|Proteomes:UP000290900};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364141};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364141}.
FT REGION 181..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..211
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..226
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 240 AA; 27648 MW; 57358BD8A4B2AE64 CRC64;
MNTTKLYHNE NTAIYTELSQ FEDELQRLAA SIQQYNPDPE IASEIVLTVD KMNSELEKIE
LLHEMRSNQI VKQNTENDQL NDNLRSILST LSDCRQELDR LPKLSSTEVS KLEDLEKVVE
EPDLDTTKQL LAYAMKLSKF SRIPRTFDGF LLPNNFVWPG DDNMRRGMLA MASMMPEKVV
EAENGGAEDT KEEEKEEEEV NKEDQSDEEM EDEPASTRRR SDVNESEVMA GLDLFDEDEE
//
