ID A0A448YNH6_BRENA Unreviewed; 665 AA.
AC A0A448YNH6;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE RecName: Full=AP complex subunit beta {ECO:0000256|PIRNR:PIRNR002291};
GN ORFNames=BRENAR_LOCUS3139 {ECO:0000313|EMBL:VEU22408.1};
OS Brettanomyces naardenensis (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Pichiaceae; Brettanomyces.
OX NCBI_TaxID=13370 {ECO:0000313|EMBL:VEU22408.1, ECO:0000313|Proteomes:UP000290900};
RN [1] {ECO:0000313|EMBL:VEU22408.1, ECO:0000313|Proteomes:UP000290900}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Tiukova I., Dainat J.;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Adaptins are components of the adaptor complexes which link
CC clathrin to receptors in coated vesicles. Clathrin-associated protein
CC complexes are believed to interact with the cytoplasmic tails of
CC membrane proteins, leading to their selection and concentration.
CC {ECO:0000256|PIRNR:PIRNR002291}.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|ARBA:ARBA00006613, ECO:0000256|PIRNR:PIRNR002291}.
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DR EMBL; CAACVR010000023; VEU22408.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A448YNH6; -.
DR STRING; 13370.A0A448YNH6; -.
DR InParanoid; A0A448YNH6; -.
DR Proteomes; UP000290900; Unassembled WGS sequence.
DR GO; GO:0030117; C:membrane coat; IEA:InterPro.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR026739; AP_beta.
DR InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR021133; HEAT_type_2.
DR PANTHER; PTHR11134; ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER; 1.
DR PANTHER; PTHR11134:SF13; AP-2 COMPLEX SUBUNIT BETA; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR PIRSF; PIRSF002291; AP_complex_beta; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|PIRNR:PIRNR002291};
KW Protein transport {ECO:0000256|PIRNR:PIRNR002291};
KW Reference proteome {ECO:0000313|Proteomes:UP000290900};
KW Transport {ECO:0000256|PIRNR:PIRNR002291}.
FT DOMAIN 15..538
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
FT REPEAT 129..167
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 606..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 665 AA; 74279 MW; 6AF86BB6E0ABDDC7 CRC64;
MGDSKLYTRV KASDILTELR NYEKKPKSSV YRKTILKKII VNLSLGDNEV VMLFNEVIKL
LQDIGPTDPE AKQLCYLYLT TYWRHKPKET LNALSFITED YHESSTDEDA CLALRTLAAI
QLPQFLEELV PMLEDALQKG SPSVRKTAAY CVASIFKAED PDSTSSLMSL LNDLLLDPQL
EVVSAALSAL GDITEKSETL KFSIDSEHAL KISQSLAVCG EWSEVAILNA LMSFVPQDHQ
TAAHIIDIVL PYLQSENSSI VLNALKVIVY LCQYVSSVLD VLPILPQSIS RAVANLMLKP
PEIQFLAMRN VILLLLDKPA LLDLDIRMFF CQYDDLLYIK DTKLEIIFLL ADEDNIEIVL
AELQEYALEI DVQMVRKSIR AIGNLAVKID GTSEKCVSVL ADLLSNSIPH VVEEIAIIAR
DILRKYPGRF DHIIQLLVDR IDLVTEQDSR ASMIWILGEY GSSISNSVAL LSHYAEHFLD
EPSETQLSLL TAIVKAHVCQ PYNKELHQLV EDTIRLVIEN VDNPDVRGRG YFYWRILSAQ
LPNTIDIIKP RLPMLNTGAD ALPPEVRQEL DLCIGTLASI YLRPVTQVFR HVKPKVFADS
PARVDQDLKT ARPRTSKSSL SRASPVPSVL SASQQLGSLS LDTATTRSRS SSLGLNGIVK
KLSRK
//
